EC 3.4.24.69: bontoxilysin

HydrolasesOpen in Browse

CatLog read 57 records for EC 3.4.24.69 from 3 papers, for 1 organism. Names in these papers: LC/F (light chain of botulinum neurotoxin serotype F), botulinum neurotoxin serotype A light chain (BoNT/A LC/A), botulinum neurotoxin serotype D light chain (LC/D).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 33 records for EC 3.4.24.69 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.24.69 in Browse.

Papers

Papers with records for EC 3.4.24.69
Paper	Organisms	Records
Molecular mechanisms of substrate recognition and specificity of botulinum neurotoxin serotype F	Clostridium botulinum	21
Mechanism of substrate recognition by botulinum neurotoxin serotype A	Clostridium botulinum	19
Unique substrate recognition mechanism of the botulinum neurotoxin D light chain	Clostridium botulinum	17

Records

Records for EC 3.4.24.69 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)	Clostridium botulinum	SNAP25	60	0.016	3.7 × 10³	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A), SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant C134A	Clostridium botulinum	SNAP25	11	0.061	190	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant C134A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant D370A	Clostridium botulinum	SNAP25	0.1	0.014	9.8	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant D370A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant D370R	Clostridium botulinum	SNAP25	0.02	0.011	1.4	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant D370R, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant E257A	Clostridium botulinum	SNAP25	1.1	0.019	54	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant E257A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant E257K	Clostridium botulinum	SNAP25	0.1	0.027	3.7	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant E257K, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant F163A	Clostridium botulinum	SNAP25	0.4	0.012	30	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant F163A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant F194A	Clostridium botulinum	SNAP25	0.2	0.009	22	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant F194A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant F194A/T220A	Clostridium botulinum	SNAP25	0.19	0.0092	20	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant F194A/T220A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant H269A	Clostridium botulinum	SNAP25	58	0.016	3.7 × 10³	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant H269A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant I115A	Clostridium botulinum	SNAP25	11	0.095	120	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant I115A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant K41A	Clostridium botulinum	SNAP25	12	0.098	120	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant K41A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant L175A	Clostridium botulinum	SNAP25	0.7	0.011	61	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant L175A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant L175A/R177A	Clostridium botulinum	SNAP25	0.8	0.0083	96	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant L175A/R177A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant Q162A	Clostridium botulinum	SNAP25	63	0.017	3.8 × 10³	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant Q162A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant R177A	Clostridium botulinum	SNAP25	1.1	0.012	91	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant R177A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant T176A	Clostridium botulinum	SNAP25	1.2	0.014	85	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant T176A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant T220A	Clostridium botulinum	SNAP25	0.3	0.02	12	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant T220A, SNAP25
botulinum neurotoxin serotype A light chain (BoNT/A LC/A)variant V129A	Clostridium botulinum	SNAP25	12	0.053	230	pH 7.6, 37 °C	PMID 17244603	Open record: botulinum neurotoxin serotype A light chain (BoNT/A LC/A) variant V129A, SNAP25
botulinum neurotoxin serotype D light chain (LC/D)	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	6.88	0.00291	2.36 × 10³	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D), vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant F50A/I191A	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	0.28	0.00481	58	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant F50A/I191A, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant F50D	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	1.6	0.00324	490	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant F50D, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant F50D/I191D	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	0.04	0.00446	8.9	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant F50D/I191D, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant H132Q	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	0.86	0.03556	24	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant H132Q, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant I151D	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	0.02	0.00796	2.5	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant I151D, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant I191D	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	1.4	0.00356	390	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant I191D, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant L200D	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	0.81	0.0024	340	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant L200D, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant P154D	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	6.35	0.01186	540	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant P154D, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant R23D/H132A	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	2.38	0.03287	72	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant R23D/H132A, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant R372A	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	0.17	0.00209	81	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant R372A, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant R63A	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	0.4	0.00219	180	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant R63A, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant R63E	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	0.15	0.00226	66	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant R63E, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant W315A	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	1.52	0.0099	150	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant W315A, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant W315D	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	3.92	0.04763	82	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant W315D, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant W44A/I152A/P154A	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	5.86	0.03245	180	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant W44A/I152A/P154A, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
botulinum neurotoxin serotype D light chain (LC/D)variant Y168D/L200D	Clostridium botulinum	vesicle-associated membrane protein-2 (VAMP-2), residues 1-97	0.12	0.00333	36	pH 7.6, 37 °C	PMID 23963459	Open record: botulinum neurotoxin serotype D light chain (LC/D) variant Y168D/L200D, vesicle-associated membrane protein-2 (VAMP-2), residues 1-97
LC/F (light chain of botulinum neurotoxin serotype F)	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	220.8	0.0071	3.11 × 10⁴	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F), vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant E200A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	0.0014	0.0072	0.19	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant E200A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant E315A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	225.8	0.0737	3.1 × 10³	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant E315A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant I52A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	3.2	0.0356	89	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant I52A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant K172A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	120.5	0.0753	1.6 × 10³	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant K172A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant L173A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	40.8	0.0158	2.7 × 10³	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant L173A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant P25A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	2.3	0.1804	13	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant P25A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant R133A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	5.2	0.1308	32	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant R133A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant R171A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	0.52	0.0838	6.2	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant R171A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant R240A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	0.52	0.0069	75	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant R240A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant R263A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	1.1	0.0067	160	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant R263A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant S147A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	198.8	0.0387	4.8 × 10³	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant S147A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant S224A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	4.2	0.0075	560	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant S224A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant V137A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	4.5	0.1405	19	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant V137A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant W319A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	200.7	0.0596	3.4 × 10³	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant W319A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant W44A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	203.5	0.2186	920	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant W44A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant Y113A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	240.8	0.0798	3 × 10³	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant Y113A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant Y168A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	0.58	0.0857	6.9	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant Y168A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant Y26A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	0.23	0.0702	0.32	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant Y26A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant Y322A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	240.8	0.0556	4.33 × 10³	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant Y322A, vesicle-associated membrane protein 2 (human, residues 1-97)
LC/F (light chain of botulinum neurotoxin serotype F)variant Y368A	Clostridium botulinum	vesicle-associated membrane protein 2 (human, residues 1-97)	0.048	0.0069	7	pH 7.6, 37 °C	PMID 21029044	Open record: LC/F (light chain of botulinum neurotoxin serotype F) variant Y368A, vesicle-associated membrane protein 2 (human, residues 1-97)