EC 3.4.24.86: ADAM 17 endopeptidase
HydrolasesOpen in Browse
CatLog read 28 records for EC 3.4.24.86 from 1 paper, for 0 organisms. Names in these papers: ADAM17 (TACE).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 4 records for EC 3.4.24.86 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.24.86 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates | — | 28 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| ADAM17 (TACE) | — | glycosylated substrate 1 (TNFα-based fluorogenic peptide)catalytic domain (CD); residues Arg215-Val477 | — | — | 32 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 1 (TNFα-based fluorogenic peptide) |
| ADAM17 (TACE) | — | glycosylated substrate 1 (TNFα-based fluorogenic peptide)catalytic domain (CD); residues Arg215-Val477 | 0.22 | — | — | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 1 (TNFα-based fluorogenic peptide) |
| ADAM17 (TACE) | — | glycosylated substrate 1 (TNFα-based fluorogenic peptide)catalytic domain (CD); residues Arg215-Val477 | — | 0.0069 | — | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 1 (TNFα-based fluorogenic peptide) |
| ADAM17 (TACE) | — | glycosylated substrate 1 (TNFα-based fluorogenic peptide)catalytic domain (CD); residues Arg215-Val477 | — | — | 36 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 1 (TNFα-based fluorogenic peptide) |
| ADAM17 (TACE) | — | glycosylated substrate 1 (TNFα-based fluorogenic peptide)catalytic domain (CD); residues Arg215-Val477 | 0.36 | — | — | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 1 (TNFα-based fluorogenic peptide) |
| ADAM17 (TACE) | — | glycosylated substrate 1 (TNFα-based fluorogenic peptide)catalytic domain (CD); residues Arg215-Val477 | — | 0.01 | — | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 1 (TNFα-based fluorogenic peptide) |
| ADAM17 (TACE) | — | glycosylated substrate 1 (TNFα-based fluorogenic peptide)ectodomain (ECD); residues Arg215-Asn671 | 0.08 | 0.0032 | 23 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 1 (TNFα-based fluorogenic peptide) |
| ADAM17 (TACE) | — | glycosylated substrate 2 (TNFα residues 73-82)ectodomain (ECD); residues Arg215-Asn671 | 0.42 | 0.0076 | 61 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 2 (TNFα residues 73-82) |
| ADAM17 (TACE) | — | glycosylated substrate 2 (TNFα residues 73-82)catalytic domain (CD); residues Arg215-Val477 | 0.08 | 0.068 | 1.1 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 2 (TNFα residues 73-82) |
| ADAM17 (TACE) | — | glycosylated substrate 3 (TNFα residues 73-82, bulkier carbohydrate)ectodomain (ECD); residues Arg215-Asn671 | 0.15 | 0.022 | 6.8 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 3 (TNFα residues 73-82, bulkier carbohydrate) |
| ADAM17 (TACE) | — | glycosylated substrate 3 (TNFα residues 73-82, bulkier carbohydrate)catalytic domain (CD); residues Arg215-Val477 | 0.06 | 0.05 | 1.2 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), glycosylated substrate 3 (TNFα residues 73-82, bulkier carbohydrate) |
| ADAM17 (TACE) | — | nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81)catalytic domain (CD); residues Arg215-Val477 | — | — | 17 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81) |
| ADAM17 (TACE) | — | nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81)catalytic domain (CD); residues Arg215-Val477 | 0.07 | — | — | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81) |
| ADAM17 (TACE) | — | nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81)catalytic domain (CD); residues Arg215-Val477 | — | 0.004 | — | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81) |
| ADAM17 (TACE) | — | nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81)catalytic domain (CD); residues Arg215-Val477 | — | — | 18 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81) |
| ADAM17 (TACE) | — | nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81)catalytic domain (CD); residues Arg215-Val477 | 0.06 | — | — | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81) |
| ADAM17 (TACE) | — | nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81)catalytic domain (CD); residues Arg215-Val477 | — | 0.0034 | — | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81) |
| ADAM17 (TACE) | — | nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81)ectodomain (ECD); residues Arg215-Asn671 | 0.1 | 0.004 | 19 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), nonglycosylated substrate 4 (TNFα-based fluorogenic peptide, residues 72-81) |
| ADAM17 (TACE) | — | substrate 5 (TNFα residues 73-82)ectodomain (ECD); residues Arg215-Asn671 | 0.2 | 0.0072 | 28 calc. | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 5 (TNFα residues 73-82) |
| ADAM17 (TACE) | — | substrate 5 (TNFα residues 73-82)catalytic domain (CD); residues Arg215-Val477 | 0.05 | 0.016 | 3.1 calc. | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 5 (TNFα residues 73-82) |
| ADAM17 (TACE) | — | substrate 6 (juxtamembrane, TNFα residues 57-82)ectodomain (ECD); residues Arg215-Asn671 | 0.34 | 0.024 | 15 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 6 (juxtamembrane, TNFα residues 57-82) |
| ADAM17 (TACE) | — | substrate 6 (juxtamembrane, TNFα residues 57-82)catalytic domain (CD); residues Arg215-Val477 | 0.12 | 0.02 | 6.2 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 6 (juxtamembrane, TNFα residues 57-82) |
| ADAM17 (TACE) | — | substrate 7 (TNFα residues 72-108)ectodomain (ECD); residues Arg215-Asn671 | 0.07 | 0.0033 | 21 calc. | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 7 (TNFα residues 72-108) |
| ADAM17 (TACE) | — | substrate 7 (TNFα residues 72-108)catalytic domain (CD); residues Arg215-Val477 | 0.03 | 0.0043 | 7.0 calc. | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 7 (TNFα residues 72-108) |
| ADAM17 (TACE) | — | substrate 8 (two α-helix-inducing heptads)ectodomain (ECD); residues Arg215-Asn671 | 0.064 | 0.0075 | 9 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 8 (two α-helix-inducing heptads) |
| ADAM17 (TACE) | — | substrate 8 (two α-helix-inducing heptads)catalytic domain (CD); residues Arg215-Val477 | 0.07 | 0.0079 | 9 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 8 (two α-helix-inducing heptads) |
| ADAM17 (TACE) | — | substrate 9 (α-helical, three α-helix-inducing heptads)ectodomain (ECD); residues Arg215-Asn671 | 0.003 | 0.002 | 1.6 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 9 (α-helical, three α-helix-inducing heptads) |
| ADAM17 (TACE) | — | substrate 9 (α-helical, three α-helix-inducing heptads)catalytic domain (CD); residues Arg215-Val477 | 0.004 | 0.0023 | 1.6 | 25 °C | PMID 23779109 | Open record: ADAM17 (TACE), substrate 9 (α-helical, three α-helix-inducing heptads) |