EC 3.5.3.1: arginase

HydrolasesOpen in Browse

CatLog read 89 records for EC 3.5.3.1 from 9 papers, for 5 organisms. Names in these papers: arginase type I (human liver arginase), arginase, arginase I, arginase I (rat liver arginase) and 2 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 106 records for EC 3.5.3.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.5.3.1 in Browse.

Papers

Papers with records for EC 3.5.3.1
Paper	Organisms	Records
New Insights into the Determinants of Specificity in Human Type I Arginase: Generation of a Mutant That Is Only Active with Agmatine as Substrate	Homo sapiens	21
Probing the role of the hyper-reactive histidine residue of arginase	Rattus norvegicus	15
The second-shell metal ligands of human arginase affect coordination of the nucleophile and substrate	Homo sapiens	14
Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I	Rattus norvegicus	9
Probing the specificity determinants of amino acid recognition by arginase	Homo sapiens, Rattus norvegicus	9
Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection	Plasmodium falciparum	7
Mutagenic and kinetic support for an allosteric site in arginase from the extreme thermophile Bacillus caldovelox, which allows activation by arginine	Bacillus caldovelox	7
Yeast epiarginase regulation, an enzyme-enzyme activity control: identification of residues of ornithine carbamoyltransferase and arginase responsible for enzyme catalytic and regulatory activities	Saccharomyces cerevisiae	4
Expression, purification, and characterization of human type II arginase	Homo sapiens	3

Records

Records for EC 3.5.3.1 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
arginase	Bacillus caldovelox	L-arginine	700	3.4	206.8	pH 9.5, 55 °C	PMID 25447142	Open record: arginase, L-arginine
arginasevariant D199A	Bacillus caldovelox	L-arginine	500	—	—	pH 9.5, 55 °C	PMID 25447142	Open record: arginase variant D199A, L-arginine
arginasevariant D199N	Bacillus caldovelox	L-arginine	400	—	—	pH 9.5, 55 °C	PMID 25447142	Open record: arginase variant D199N, L-arginine
arginasevariant E256A	Bacillus caldovelox	L-arginine	300	—	—	pH 9.5, 55 °C	PMID 25447142	Open record: arginase variant E256A, L-arginine
arginasevariant E256Q	Bacillus caldovelox	L-arginine	400	—	—	pH 9.5, 55 °C	PMID 25447142	Open record: arginase variant E256Q, L-arginine
arginasevariant E278A	Bacillus caldovelox	L-arginine	750	5	150 calc.	pH 9.5, 55 °C	PMID 25447142	Open record: arginase variant E278A, L-arginine
arginasevariant E278A/E256A	Bacillus caldovelox	L-arginine	300	—	—	pH 9.5, 55 °C	PMID 25447142	Open record: arginase variant E278A/E256A, L-arginine
arginase	Plasmodium falciparum	L-arginine	440	3.3	130	pH 8.5, 37 °C	PMID 20527960	Open record: arginase, L-arginine
arginase	Plasmodium falciparum	L-arginine	320	4	80	pH 8, 37 °C	PMID 20527960	Open record: arginase, L-arginine
arginase	Plasmodium falciparum	L-arginine	77	25	3	pH 7.4, 37 °C	PMID 20527960	Open record: arginase, L-arginine
arginase	Plasmodium falciparum	L-arginine	76	12	2.9	pH 8, 37 °C	PMID 20527960	Open record: arginase, L-arginine
arginaseL8 chimera (residues D374-T392 replaced by the human arginase I sequence)	Plasmodium falciparum	L-arginine	—	20	—	pH 8, 37 °C	PMID 20527960	Open record: arginase L8 chimera (residues D374-T392 replaced by the human arginase I sequence), L-arginine
arginasedN-PFA-L2S (loop L2 residues N84-D157 deleted)	Plasmodium falciparum	L-arginine	—	4	—	pH 8, 37 °C	PMID 20527960	Open record: arginase dN-PFA-L2S (loop L2 residues N84-D157 deleted), L-arginine
arginasevariant H381A	Plasmodium falciparum	L-arginine	28	10	2.7	pH 8, 37 °C	PMID 20527960	Open record: arginase variant H381A, L-arginine
arginase	Saccharomyces cerevisiae	L-arginine	—	6.5	—	30 °C	PMID 12679340	Open record: arginase, L-arginine
arginasevariant C321R/C326T	Saccharomyces cerevisiae	L-arginine	—	7.1	—	30 °C	PMID 12679340	Open record: arginase variant C321R/C326T, L-arginine
arginasevariant H309K/H312E	Saccharomyces cerevisiae	L-arginine	—	6.9	—	30 °C	PMID 12679340	Open record: arginase variant H309K/H312E, L-arginine
arginasevariant H309K/H312E/C321R/C326T	Saccharomyces cerevisiae	L-arginine	—	6.7	—	30 °C	PMID 12679340	Open record: arginase variant H309K/H312E/C321R/C326T, L-arginine
arginase Ivariant D183A	Homo sapiens	L-arginine	68	136	0.5	pH 9	PMID 19093830	Open record: arginase I variant D183A, L-arginine
arginase Ivariant D183N	Homo sapiens	L-arginine	167	40	4.2	pH 9	PMID 19093830	Open record: arginase I variant D183N, L-arginine
arginase I	Rattus norvegicus	L-arginine	350	1	350	pH 9	PMID 19093830	Open record: arginase I, L-arginine
arginase Ivariant D128A	Rattus norvegicus	L-arginine	0.003	1	0.003	pH 9	PMID 12820884	Open record: arginase I variant D128A, L-arginine
arginase Ivariant D128E	Rattus norvegicus	L-arginine	0.07	1.4	0.05	pH 9	PMID 12820884	Open record: arginase I variant D128E, L-arginine
arginase Ivariant D128N	Rattus norvegicus	L-arginine	0.003	1.1	0.003	pH 9	PMID 12820884	Open record: arginase I variant D128N, L-arginine
arginase Ivariant D183A	Rattus norvegicus	L-arginine	14.7	13.9	1.1	pH 9	PMID 19093830	Open record: arginase I variant D183A, L-arginine
arginase Ivariant D232A	Rattus norvegicus	L-arginine	0.012	1.6	0.007	pH 9	PMID 12820884	Open record: arginase I variant D232A, L-arginine
arginase Ivariant D232C	Rattus norvegicus	L-arginine	1.5	1	1.5	pH 9	PMID 12820884	Open record: arginase I variant D232C, L-arginine
arginase Ivariant D234A	Rattus norvegicus	L-arginine	0.4	2.5	0.16	pH 9	PMID 12820884	Open record: arginase I variant D234A, L-arginine
arginase Ivariant D234E	Rattus norvegicus	L-arginine	6.6	2.5	2.6	pH 9	PMID 12820884	Open record: arginase I variant D234E, L-arginine
arginase Ivariant D234H	Rattus norvegicus	L-arginine	0.2	2.5	0.08	pH 9	PMID 12820884	Open record: arginase I variant D234H, L-arginine
arginase Ivariant H101E	Rattus norvegicus	L-arginine	7.7	2.9	2.6	pH 9	PMID 12820884	Open record: arginase I variant H101E, L-arginine
arginase Ivariant N130A	Rattus norvegicus	L-arginine	220	50	4.4	pH 9	PMID 19093830	Open record: arginase I variant N130A, L-arginine
arginase Ivariant N130F	Rattus norvegicus	L-arginine	4.8	19.3	0.25	pH 9	PMID 19093830	Open record: arginase I variant N130F, L-arginine
arginase Ivariant N130Y	Rattus norvegicus	L-arginine	17	21.4	0.79	pH 9	PMID 19093830	Open record: arginase I variant N130Y, L-arginine
arginase Ivariant T135A	Rattus norvegicus	L-arginine	260	13	20	pH 9	PMID 19093830	Open record: arginase I variant T135A, L-arginine
arginase Ivariant T135S	Rattus norvegicus	L-arginine	350	2.5	140	pH 9	PMID 19093830	Open record: arginase I variant T135S, L-arginine
arginase I (rat liver arginase)variant C119A/C168A/C303A	Rattus norvegicus	L-thioarginine	380	1	380 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant C119A/C168A/C303A, L-thioarginine
arginase I (rat liver arginase)variant C119A/C168A/C303A/H141A/Q19C	Rattus norvegicus	L-thioarginine	3.5	1.6	2.2 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant C119A/C168A/C303A/H141A/Q19C, L-thioarginine
arginase I (rat liver arginase)variant C119A/C168A/C303A/H141A/Q19C-2EI	Rattus norvegicus	L-thioarginine	3.2	0.43	7.4 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant C119A/C168A/C303A/H141A/Q19C-2EI, L-thioarginine
arginase I (rat liver arginase)variant C119A/C168A/C303A/H141A/Q19C-2MI	Rattus norvegicus	L-thioarginine	8.2	0.8	10 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant C119A/C168A/C303A/H141A/Q19C-2MI, L-thioarginine
arginase I (rat liver arginase)variant C119A/C168A/C303A/H141A/Q19C-4MI	Rattus norvegicus	L-thioarginine	2.2	1	2.2 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant C119A/C168A/C303A/H141A/Q19C-4MI, L-thioarginine
arginase I (rat liver arginase)variant C119A/C168A/C303A/H141A/Q19C-BA	Rattus norvegicus	L-thioarginine	9.9	0.7	14 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant C119A/C168A/C303A/H141A/Q19C-BA, L-thioarginine
arginase I (rat liver arginase)variant C119A/C168A/C303A/H141A/Q19C-PA	Rattus norvegicus	L-thioarginine	0.55	0.4	1.4 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant C119A/C168A/C303A/H141A/Q19C-PA, L-thioarginine
arginase I (rat liver arginase)variant H141A	Rattus norvegicus	L-arginine	0.5	0.9	0.56	pH 9	PMID 16266687	Open record: arginase I (rat liver arginase) variant H141A, L-arginine
arginase I (rat liver arginase)variant H141A	Rattus norvegicus	L-thioarginine	9.7	1	9.7 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant H141A, L-thioarginine
arginase I (rat liver arginase)variant H141A/Q19N	Rattus norvegicus	L-thioarginine	5	1.5	3.3 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant H141A/Q19N, L-thioarginine
arginase I (rat liver arginase)variant H141C	Rattus norvegicus	L-thioarginine	10	1.3	7.7 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant H141C, L-thioarginine
arginase I (rat liver arginase)variant H141C-2MI	Rattus norvegicus	L-thioarginine	6.2	1.8	3.4 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant H141C-2MI, L-thioarginine
arginase I (rat liver arginase)variant H141C-4EI	Rattus norvegicus	L-thioarginine	10.3	1.6	6.4 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant H141C-4EI, L-thioarginine
arginase I (rat liver arginase)variant H141C-4MI	Rattus norvegicus	L-thioarginine	6	1	6.0 calc.	pH 9, 30 °C	PMID 16266687	Open record: arginase I (rat liver arginase) variant H141C-4MI, L-thioarginine
arginase I (rat liver arginase)variant H141D	Rattus norvegicus	L-arginine	0.048	1.1	0.045	pH 9	PMID 16266687	Open record: arginase I (rat liver arginase) variant H141D, L-arginine
arginase type I (human liver arginase)	Homo sapiens	L-arginine	190	1.5	126	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase), L-arginine
arginase type I (human liver arginase)variant D181T	Homo sapiens	L-arginine	191	5.3	36	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant D181T, L-arginine
arginase type I (human liver arginase)variant D181T/V182E	Homo sapiens	L-arginine	188	32	5.8	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant D181T/V182E, L-arginine
arginase type I (human liver arginase)variant D181T/V182E + ins F (Phe inserted after E182)	Homo sapiens	L-arginine	8.1	20	0.35	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant D181T/V182E + ins F (Phe inserted after E182), L-arginine
arginase type I (human liver arginase)variant I129T/N130Y/T131A (chimera A1)	Homo sapiens	L-arginine	6.2	2.5	2.4	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant I129T/N130Y/T131A (chimera A1), L-arginine
arginase type I (human liver arginase)variant I129T/N130Y/T131A/ΔP132-T134 (chimera A2)	Homo sapiens	agmatine	1.1	6	0.18	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant I129T/N130Y/T131A/ΔP132-T134 (chimera A2), agmatine
arginase type I (human liver arginase)variant N130D	Homo sapiens	agmatine	3	1.4	2.1	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N130D, agmatine
arginase type I (human liver arginase)variant N130D	Homo sapiens	L-arginine	33	13.3	2.5	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N130D, L-arginine
arginase type I (human liver arginase)variant N130D/N139D	Homo sapiens	agmatine	1.6	1.1	1.4	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N130D/N139D, agmatine
arginase type I (human liver arginase)variant N130D/N139D	Homo sapiens	L-arginine	33	6.1	5.4	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N130D/N139D, L-arginine
arginase type I (human liver arginase)variant N130D/S137C	Homo sapiens	agmatine	2.3	1.7	1.3	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N130D/S137C, agmatine
arginase type I (human liver arginase)variant N130D/S137C	Homo sapiens	L-arginine	23	6.5	3.5	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N130D/S137C, L-arginine
arginase type I (human liver arginase)variant N130D/S137C/N139D	Homo sapiens	agmatine	0.9	1.6	0.56	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N130D/S137C/N139D, agmatine
arginase type I (human liver arginase)variant N130D/S137C/N139D	Homo sapiens	L-arginine	4	6.9	0.58	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N130D/S137C/N139D, L-arginine
arginase type I (human liver arginase)variant N139D	Homo sapiens	agmatine	1.3	5.3	0.25	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N139D, agmatine
arginase type I (human liver arginase)variant N139D	Homo sapiens	L-arginine	64	4.4	14	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant N139D, L-arginine
arginase type I (human liver arginase)variant S137C	Homo sapiens	agmatine	1.8	7.5	0.24	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant S137C, agmatine
arginase type I (human liver arginase)variant S137C	Homo sapiens	L-arginine	75	3.2	23	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant S137C, L-arginine
arginase type I (human liver arginase)variant S137C/N139D	Homo sapiens	agmatine	1.1	0.9	1.2	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant S137C/N139D, agmatine
arginase type I (human liver arginase)variant S137C/N139D	Homo sapiens	L-arginine	83	10.8	7.7	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant S137C/N139D, L-arginine
arginase type I (human liver arginase)variant V182E	Homo sapiens	L-arginine	187	2.4	77	pH 9.5	PMID 35742891	Open record: arginase type I (human liver arginase) variant V182E, L-arginine
human arginase I (hArgI)variant D181E	Homo sapiens	L-arginine	344	0.27	1.27 × 10³	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant D181E, L-arginine
human arginase I (hArgI)variant D181E/S230A	Homo sapiens	L-arginine	220	0.15	1.47 × 10³	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant D181E/S230A, L-arginine
human arginase I (hArgI)variant D181N	Homo sapiens	L-argininewith Co(II) (100 microM CoCl2)	387	0.3	1.29 × 10³	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant D181N, L-arginine
human arginase I (hArgI)variant D181N	Homo sapiens	L-argininewith Mn(II)	360	3	120	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant D181N, L-arginine
human arginase I (hArgI)variant D181N/S230G	Homo sapiens	L-argininewith Co(II) (100 microM CoCl2)	247	0.21	1.18 × 10³	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant D181N/S230G, L-arginine
human arginase I (hArgI)variant D181N/S230G	Homo sapiens	L-argininewith Mn(II)	517	2.8	185	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant D181N/S230G, L-arginine
human arginase I (hArgI)variant D181S	Homo sapiens	L-arginine	388	0.28	1.39 × 10³	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant D181S, L-arginine
human arginase I (hArgI)variant D181S/S230G	Homo sapiens	L-arginine	180	0.19	950	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant D181S/S230G, L-arginine
human arginase I (hArgI)variant S230C	Homo sapiens	L-argininewith Co(II) (100 microM CoCl2)	327	0.15	2.18 × 10³	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant S230C, L-arginine
human arginase I (hArgI)variant S230C	Homo sapiens	L-argininewith Mn(II)	285	2.1	136	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant S230C, L-arginine
human arginase I (hArgI)variant S230D	Homo sapiens	L-arginine	140	0.15	930	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant S230D, L-arginine
human arginase I (hArgI)variant S230G	Homo sapiens	L-argininewith Co(II) (100 microM CoCl2)	200	0.08	2.6 × 10³	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant S230G, L-arginine
human arginase I (hArgI)variant S230G	Homo sapiens	L-argininewith Mn(II)	266	0.8	330	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant S230G, L-arginine
human arginase I (hArgI)variant S230T	Homo sapiens	L-arginine	315	0.16	1.97 × 10³	pH 7.4, 37 °C	PMID 21053939	Open record: human arginase I (hArgI) variant S230T, L-arginine
type II arginase	Homo sapiens	L-arginine	231	0.31	750 calc.	pH 9.5	PMID 11370664	Open record: type II arginase, L-arginine
type II arginase	Homo sapiens	L-arginine	203	4.8	42 calc.	pH 7.5	PMID 11370664	Open record: type II arginase, L-arginine
type II arginase	Homo sapiens	L-arginine	—	0.55	—	pH 9	PMID 11370664	Open record: type II arginase, L-arginine