EC 3.5.3.18: dimethylargininase

HydrolasesOpen in Browse

CatLog read 13 records for EC 3.5.3.18 from 2 papers, for 2 organisms. Names in these papers: DDAH-1 (dimethylarginine dimethylaminohydrolase-1), dimethylarginine dimethylaminohydrolase (Pa DDAH).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 12 records for EC 3.5.3.18 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.5.3.18 in Browse.

Papers

Papers with records for EC 3.5.3.18
Paper	Organisms	Records
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide	Homo sapiens	7
Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis	Pseudomonas aeruginosa	6

Records

Records for EC 3.5.3.18 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
DDAH-1 (dimethylarginine dimethylaminohydrolase-1)	Homo sapiens	S-methyl-L-thiocitrulline	0.0418	0.0031	13.5	pH 7.27	PMID 19663506	Open record: DDAH-1 (dimethylarginine dimethylaminohydrolase-1), S-methyl-L-thiocitrulline
DDAH-1 (dimethylarginine dimethylaminohydrolase-1)variant E78A	Homo sapiens	N-omega,N-omega-dimethyl-L-arginine	0.0015	13.7	1.2 × 10⁻⁴		PMID 19663506	Open record: DDAH-1 (dimethylarginine dimethylaminohydrolase-1) variant E78A, N-omega,N-omega-dimethyl-L-arginine
DDAH-1 (dimethylarginine dimethylaminohydrolase-1)variant E78A	Homo sapiens	S-methyl-L-thiocitrulline	0.03	0.019	1.58	pH 7.27	PMID 19663506	Open record: DDAH-1 (dimethylarginine dimethylaminohydrolase-1) variant E78A, S-methyl-L-thiocitrulline
DDAH-1 (dimethylarginine dimethylaminohydrolase-1)variant L271G	Homo sapiens	N-omega,N-omega-dimethyl-L-arginine	0.0087	0.75	0.0115		PMID 19663506	Open record: DDAH-1 (dimethylarginine dimethylaminohydrolase-1) variant L271G, N-omega,N-omega-dimethyl-L-arginine
DDAH-1 (dimethylarginine dimethylaminohydrolase-1)variant L271G	Homo sapiens	S-methyl-L-thiocitrulline	0.0097	0.0014	6.8	pH 7.27	PMID 19663506	Open record: DDAH-1 (dimethylarginine dimethylaminohydrolase-1) variant L271G, S-methyl-L-thiocitrulline
DDAH-1 (dimethylarginine dimethylaminohydrolase-1)variant L30A	Homo sapiens	N-omega,N-omega-dimethyl-L-arginine	0.0168	1.4	0.012		PMID 19663506	Open record: DDAH-1 (dimethylarginine dimethylaminohydrolase-1) variant L30A, N-omega,N-omega-dimethyl-L-arginine
DDAH-1 (dimethylarginine dimethylaminohydrolase-1)variant L30A	Homo sapiens	S-methyl-L-thiocitrulline	0.0418	0.0036	11.7	pH 7.27	PMID 19663506	Open record: DDAH-1 (dimethylarginine dimethylaminohydrolase-1) variant L30A, S-methyl-L-thiocitrulline
dimethylarginine dimethylaminohydrolase (Pa DDAH)	Pseudomonas aeruginosa	asymmetric Nω,Nω-dimethyl-L-arginine	0.56	0.31	1.8	pH 6.2, 25 °C	PMID 15865451	Open record: dimethylarginine dimethylaminohydrolase (Pa DDAH), asymmetric Nω,Nω-dimethyl-L-arginine
dimethylarginine dimethylaminohydrolase (Pa DDAH)	Pseudomonas aeruginosa	L-arginine	0.0017	0.94	0.0018	pH 6.2, 25 °C	PMID 15865451	Open record: dimethylarginine dimethylaminohydrolase (Pa DDAH), L-arginine
dimethylarginine dimethylaminohydrolase (Pa DDAH)	Pseudomonas aeruginosa	Nω-amino-L-arginine	0.12	1.11	0.108	pH 6.2, 25 °C	PMID 15865451	Open record: dimethylarginine dimethylaminohydrolase (Pa DDAH), Nω-amino-L-arginine
dimethylarginine dimethylaminohydrolase (Pa DDAH)	Pseudomonas aeruginosa	Nω-hydroxy-L-arginine	0.33	2.3	0.15	pH 6.2, 25 °C	PMID 15865451	Open record: dimethylarginine dimethylaminohydrolase (Pa DDAH), Nω-hydroxy-L-arginine
dimethylarginine dimethylaminohydrolase (Pa DDAH)	Pseudomonas aeruginosa	Nω-methyl-L-arginine	0.31	0.67	0.47	pH 6.2, 25 °C	PMID 15865451	Open record: dimethylarginine dimethylaminohydrolase (Pa DDAH), Nω-methyl-L-arginine
dimethylarginine dimethylaminohydrolase (Pa DDAH)	Pseudomonas aeruginosa	S-methyl-L-thiocitrulline	0.84	0.143	5.8	pH 6.2, 25 °C	PMID 15865451	Open record: dimethylarginine dimethylaminohydrolase (Pa DDAH), S-methyl-L-thiocitrulline