EC 3.6.1.6: nucleoside diphosphate phosphatase
HydrolasesOpen in Browse
CatLog read 32 records for EC 3.6.1.6 from 3 papers, for 3 organisms. Names in these papers: Ntdp (nucleoside tri- and diphosphatase, Sa1684), β-ureidopropionase (HsβUP), SA1684 protein (nucleoside diphosphatase), Sc4828 (DUF402 domain-containing protein).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 11 records for EC 3.6.1.6 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.6.1.6 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| The structural mechanism for the nucleoside tri- and diphosphate hydrolysis activity of Ntdp from Staphylococcus aureus | Staphylococcus aureus, Streptomyces coelicolor | 17 |
| Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism | Homo sapiens | 10 |
| Novel Nucleoside Diphosphatase Contributes to Staphylococcus aureus Virulence | Staphylococcus aureus | 5 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| Ntdp (nucleoside tri- and diphosphatase, Sa1684) | Staphylococcus aureus | adenosine 5'-diphosphate | 2.3 | 0.6456 | 3.5 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684), adenosine 5'-diphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684) | Staphylococcus aureus | adenosine 5'-triphosphate | 0.57 | 0.38 | 1.48 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684), adenosine 5'-triphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684) | Staphylococcus aureus | guanosine 5'-diphosphate | 0.7 | 0.2115 | 3.32 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684), guanosine 5'-diphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684) | Staphylococcus aureus | guanosine 5'-triphosphate | 1.73 | 0.0847 | 20.63 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684), guanosine 5'-triphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant E126A | Staphylococcus aureus | adenosine 5'-diphosphate | 0.077 | 0.6586 | 0.12 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant E126A, adenosine 5'-diphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant E126A | Staphylococcus aureus | adenosine 5'-triphosphate | 0.018 | 0.5158 | 0.033 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant E126A, adenosine 5'-triphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant E126A | Staphylococcus aureus | guanosine 5'-diphosphate | 0.02 | 0.1731 | 0.12 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant E126A, guanosine 5'-diphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant E126A | Staphylococcus aureus | guanosine 5'-triphosphate | 0.012 | 0.077 | 0.15 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant E126A, guanosine 5'-triphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant N45A | Staphylococcus aureus | adenosine 5'-triphosphate | 0.33 | 0.0746 | 4.45 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant N45A, adenosine 5'-triphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant W58A | Staphylococcus aureus | adenosine 5'-diphosphate | 0.433 | 0.864 | 0.5 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant W58A, adenosine 5'-diphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant W58A | Staphylococcus aureus | guanosine 5'-diphosphate | 0.325 | 0.7595 | 0.43 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant W58A, guanosine 5'-diphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant Y88A | Staphylococcus aureus | adenosine 5'-diphosphate | 0.24 | 0.8921 | 0.27 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant Y88A, adenosine 5'-diphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant Y88A | Staphylococcus aureus | adenosine 5'-triphosphate | 0.623 | 0.8844 | 0.7 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant Y88A, adenosine 5'-triphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant Y88A | Staphylococcus aureus | guanosine 5'-diphosphate | 0.203 | 0.782 | 0.25 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant Y88A, guanosine 5'-diphosphate | |
| Ntdp (nucleoside tri- and diphosphatase, Sa1684)variant Y88A | Staphylococcus aureus | guanosine 5'-triphosphate | 0.033 | 0.6384 | 0.52 | PMID 33955674 | Open record: Ntdp (nucleoside tri- and diphosphatase, Sa1684) variant Y88A, guanosine 5'-triphosphate | |
| SA1684 protein (nucleoside diphosphatase) | Staphylococcus aureus | adenosine 5'-diphosphate | 0.415 | 0.0963 | 4.31 calc. | pH 7.5, 26 °C | PMID 27422825 | Open record: SA1684 protein (nucleoside diphosphatase), adenosine 5'-diphosphate |
| SA1684 protein (nucleoside diphosphatase) | Staphylococcus aureus | cytidine 5'-diphosphate | 0.763 | 0.303 | 2.52 calc. | pH 7.5, 26 °C | PMID 27422825 | Open record: SA1684 protein (nucleoside diphosphatase), cytidine 5'-diphosphate |
| SA1684 protein (nucleoside diphosphatase) | Staphylococcus aureus | guanosine 5'-diphosphate | 0.357 | 0.102 | 3.50 calc. | pH 7.5, 26 °C | PMID 27422825 | Open record: SA1684 protein (nucleoside diphosphatase), guanosine 5'-diphosphate |
| SA1684 protein (nucleoside diphosphatase) | Staphylococcus aureus | thymidine 5'-diphosphate | 0.68 | 0.203 | 3.4 calc. | pH 7.5, 26 °C | PMID 27422825 | Open record: SA1684 protein (nucleoside diphosphatase), thymidine 5'-diphosphate |
| SA1684 protein (nucleoside diphosphatase) | Staphylococcus aureus | uridine 5'-diphosphate | 1.388 | 0.221 | 6.28 calc. | pH 7.5, 26 °C | PMID 27422825 | Open record: SA1684 protein (nucleoside diphosphatase), uridine 5'-diphosphate |
| Sc4828 (DUF402 domain-containing protein) | Streptomyces coelicolor | adenosine 5'-diphosphate | 1.003 | 0.0885 | 11.33 | PMID 33955674 | Open record: Sc4828 (DUF402 domain-containing protein), adenosine 5'-diphosphate | |
| Sc4828 (DUF402 domain-containing protein) | Streptomyces coelicolor | guanosine 5'-diphosphate | 0.9 | 0.0549 | 16.33 | PMID 33955674 | Open record: Sc4828 (DUF402 domain-containing protein), guanosine 5'-diphosphate | |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanine | 0.47 | — | — | pH 6.5, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanine | — | 0.048 | — | pH 6.5, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanine | — | — | 9.8 | pH 6.5, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanine5-aminolevulinic acid (5-ALA, competitive inhibitor) | 0.44 | — | — | pH 6.5, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanine5-aminolevulinic acid (5-ALA, competitive inhibitor) | — | 0.099 | — | pH 6.5, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanine5-aminolevulinic acid (5-ALA, competitive inhibitor) | — | — | 4.5 | pH 6.5, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanineβ-alanine (product, competitive inhibitor) | 0.5 | — | — | pH 6.5, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanineβ-alanine (product, competitive inhibitor); apparent Km | — | 0.084 | — | pH 6.5, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanineβ-alanine (product, competitive inhibitor); apparent kcat/Km | — | — | 6 | pH 6.5, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |
| β-ureidopropionase (HsβUP) | Homo sapiens | N-carbamoyl-β-alanine | 0.31 | — | — | pH 7.4, 37 °C | PMID 29976570 | Open record: β-ureidopropionase (HsβUP), N-carbamoyl-β-alanine |