CatLogenzyme kinetics catalog

EC 3.6.1.61: diadenosine hexaphosphate hydrolase (ATP-forming)

HydrolasesOpen in Browse

CatLog read 25 records for EC 3.6.1.61 from 3 papers, for 1 organism. Names in these papers: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1), DIPP (diphosphoinositol polyphosphate phosphohydrolase), Nudt3 (DIPP).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 19 records for EC 3.6.1.61 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.6.1.61 in Browse.

Papers

PaperOrganismsRecords
New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1Homo sapiens21
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping…Homo sapiens3
Optimization of a high throughput screening platform to identify inhibitors of asymmetric diadenosine polyphosphatasesHomo sapiens1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
DIPP (diphosphoinositol polyphosphate phosphohydrolase)Homo sapiensdiadenosine 5',5'''-P1,P5-pentaphosphate0.420.007755pH 7.6, 37 °CPMID 10419486Open
DIPP (diphosphoinositol polyphosphate phosphohydrolase)Homo sapiensdiadenosine 5',5'''-P1,P6-hexaphosphate0.50.005985pH 7.6, 37 °CPMID 10419486Open
DIPP (diphosphoinositol polyphosphate phosphohydrolase)Homo sapiensdiphosphoinositol pentakisphosphate0.24.2 × 10⁻⁶4.74 × 10⁴pH 7.2PMID 10419486Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)Homo sapiens1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate0.237—1.5 × 10³pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)Homo sapiens1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate0.165—1.79 × 10³pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)Homo sapiens2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate0.042—460pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)Homo sapiens4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate0.029—210pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)Homo sapiens5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate0.081—650pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)Homo sapiens5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate0.095—380pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42AHomo sapiens1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate——520pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42AHomo sapiens1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate——680pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42AHomo sapiens5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate——150pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42A/R45AHomo sapiens1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate——110pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42A/R45AHomo sapiens1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate——200pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42A/R45AHomo sapiens5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate——80pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant K18AHomo sapiens1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate——50pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant K18AHomo sapiens1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate——70pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant K18AHomo sapiens5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate——40pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R41AHomo sapiens1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate——590pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R41AHomo sapiens1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate——690pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R41AHomo sapiens5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate——230pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R45AHomo sapiens1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate——540pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R45AHomo sapiens1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate——860pH 7.2PMID 33475202Open
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R45AHomo sapiens5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate——300pH 7.2PMID 33475202Open
Nudt3 (DIPP)Homo sapiensP1,P5-di(adenosine-5') pentaphosphate4 × 10⁻⁴0.0240.016pH 8, 23 °CPMID 39521360Open