EC 3.6.1.66: XTP/dITP diphosphatase
HydrolasesOpen in Browse
CatLog read 47 records for EC 3.6.1.66 from 4 papers, for 5 organisms. Names in these papers: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), Mj0226 protein (nucleotide triphosphatase, NTPase), inosine triphosphate pyrophosphatase (ITPA), HAM1 protein (RdgB homolog) and 3 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 3 records for EC 3.6.1.66 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.6.1.66 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii | Methanococcus jannaschii | 23 |
| Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase | Escherichia coli, Homo sapiens and 2 more | 12 |
| Structure-based identification of a novel NTPase from Methanococcus jannaschii | Methanococcus jannaschii | 7 |
| Arginine-178 is an essential residue for ITPA function | Homo sapiens | 5 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| HAM1 protein (RdgB homolog) | Saccharomyces cerevisiae | 2'-deoxy-N-6-hydroxylaminopurine triphosphate | 23.4 | 0.0269 | 870 | pH 9.5, 37 °C | PMID 17090528 | Open record: HAM1 protein (RdgB homolog), 2'-deoxy-N-6-hydroxylaminopurine triphosphate |
| HAM1 protein (RdgB homolog) | Saccharomyces cerevisiae | 2'-deoxyguanosine 5'-triphosphate | 20.9 | 0.772 | 27.1 | pH 9.5, 37 °C | PMID 17090528 | Open record: HAM1 protein (RdgB homolog), 2'-deoxyguanosine 5'-triphosphate |
| HAM1 protein (RdgB homolog) | Saccharomyces cerevisiae | deoxyinosine triphosphate | 33.5 | 0.0134 | 2.5 × 10³ | pH 9.5, 37 °C | PMID 17090528 | Open record: HAM1 protein (RdgB homolog), deoxyinosine triphosphate |
| inosine triphosphate pyrophosphatase (ITPA) | Homo sapiens | inosine triphosphate | 4.7 | 0.0117 | 401 | 37 °C | PMID 37506994 | Open record: inosine triphosphate pyrophosphatase (ITPA), inosine triphosphate |
| inosine triphosphate pyrophosphatase (ITPA)variant R178A | Homo sapiens | inosine triphosphate | 0.022 | 0.115 | 0.2 | 37 °C | PMID 37506994 | Open record: inosine triphosphate pyrophosphatase (ITPA) variant R178A, inosine triphosphate |
| inosine triphosphate pyrophosphatase (ITPA)variant R178C | Homo sapiens | inosine triphosphate | 0.038 | 0.0184 | 2.1 | 37 °C | PMID 37506994 | Open record: inosine triphosphate pyrophosphatase (ITPA) variant R178C, inosine triphosphate |
| inosine triphosphate pyrophosphatase (ITPA)variant R178K | Homo sapiens | inosine triphosphate | 3.3 | 0.216 | 15.2 | 37 °C | PMID 37506994 | Open record: inosine triphosphate pyrophosphatase (ITPA) variant R178K, inosine triphosphate |
| inosine triphosphate pyrophosphatase (ITPA)variant R178S | Homo sapiens | inosine triphosphate | 0.072 | 0.116 | 0.62 | 37 °C | PMID 37506994 | Open record: inosine triphosphate pyrophosphatase (ITPA) variant R178S, inosine triphosphate |
| ITPase (human RdgB homolog) | Homo sapiens | 2'-deoxy-N-6-hydroxylaminopurine triphosphate | 85.3 | 0.0407 | 2097 | pH 9.5, 37 °C | PMID 17090528 | Open record: ITPase (human RdgB homolog), 2'-deoxy-N-6-hydroxylaminopurine triphosphate |
| ITPase (human RdgB homolog) | Homo sapiens | 2'-deoxyguanosine 5'-triphosphate | 12.1 | 0.993 | 12.2 | pH 9.5, 37 °C | PMID 17090528 | Open record: ITPase (human RdgB homolog), 2'-deoxyguanosine 5'-triphosphate |
| ITPase (human RdgB homolog) | Homo sapiens | deoxyinosine triphosphate | 79.6 | 0.0325 | 2448 | pH 9.5, 37 °C | PMID 17090528 | Open record: ITPase (human RdgB homolog), deoxyinosine triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 2',3'-dideoxyguanosine 5'-triphosphate | 3.33 | 2.78 | 1.20 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 2',3'-dideoxyguanosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 2'-deoxyadenosine 5'-triphosphate | 0.44 | 7.3 | 0.060 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 2'-deoxyadenosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 2'-deoxycytidine 5'-triphosphate | 0.44 | 5.47 | 0.080 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 2'-deoxycytidine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 2'-deoxyguanosine 5'-triphosphate | 9.33 | 2.12 | 4.40 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 2'-deoxyguanosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 2'-deoxyinosine 5'-triphosphate | 152.4 | 0.25 | 610 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 2'-deoxyinosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 2'-deoxyuridine 5'-triphosphate | 5.78 | 4.22 | 1.37 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 2'-deoxyuridine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 2,6-diamino-PuTP | 0.44 | 10.8 | 0.041 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 2,6-diamino-PuTP |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 2-amino-6-Cl-PuTP | 0.67 | 15.2 | 0.044 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 2-amino-6-Cl-PuTP |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 2-amino-PuTP | 0.44 | 24.2 | 0.018 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 2-amino-PuTP |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 3'-deoxyguanosine 5'-triphosphate | 8.22 | 2.87 | 2.86 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 3'-deoxyguanosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 5'-guanylylimidodiphosphate | 0.67 | 3.26 | 0.21 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 5'-guanylylimidodiphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 6-Cl-PuTP | 0.89 | 12.4 | 0.072 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 6-Cl-PuTP |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 6-N-hydroxylaminopurine deoxynucleoside triphosphate | 1.78 | 3.3 | 0.54 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 6-N-hydroxylaminopurine deoxynucleoside triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 7-deaza-2'-deoxyguanosine 5'-triphosphate | 3.33 | 3.24 | 1.03 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 7-deaza-2'-deoxyguanosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 8-bromo-2'-deoxyguanosine 5'-triphosphate | 5.55 | 6.1 | 0.91 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 8-bromo-2'-deoxyguanosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | 8-oxo-2'-deoxyguanosine 5'-triphosphate | 2.44 | 5.3 | 0.46 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), 8-oxo-2'-deoxyguanosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | deoxynebularine triphosphate | 0.22 | 29 | 0.0076 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), deoxynebularine triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | Etheno-dATP | 0.67 | 8.2 | 0.082 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), Etheno-dATP |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | GTP-γ-S | 0.45 | 3.71 | 0.12 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), GTP-γ-S |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | guanosine 5'-triphosphate | 9.11 | 1.94 | 4.70 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), guanosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | inosine 5'-triphosphate | 155.8 | 0.24 | 650 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), inosine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | thymidine 5'-triphosphate | 1.78 | 4.4 | 0.40 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), thymidine 5'-triphosphate |
| Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase) | Methanococcus jannaschii | xanthosine 5'-triphosphate | 176.4 | 0.22 | 800 calc. | pH 10.5, 80 °C | PMID 11452035 | Open record: Mj0226 protein (hypoxanthine/xanthine dNTP pyrophosphatase), xanthosine 5'-triphosphate |
| Mj0226 protein (nucleotide triphosphatase, NTPase) | Methanococcus jannaschii | 2'-deoxyguanosine 5'-triphosphate | 96.64 | 1.13 | 85.52 | pH 7.6, 80 °C | PMID 10404228 | Open record: Mj0226 protein (nucleotide triphosphatase, NTPase), 2'-deoxyguanosine 5'-triphosphate |
| Mj0226 protein (nucleotide triphosphatase, NTPase) | Methanococcus jannaschii | adenosine 5'-triphosphate | 1.02 | 7.04 | 0.15 | pH 7.6, 80 °C | PMID 10404228 | Open record: Mj0226 protein (nucleotide triphosphatase, NTPase), adenosine 5'-triphosphate |
| Mj0226 protein (nucleotide triphosphatase, NTPase) | Methanococcus jannaschii | cytidine 5'-triphosphate | 2.23 | 1.45 | 1.54 | pH 7.6, 80 °C | PMID 10404228 | Open record: Mj0226 protein (nucleotide triphosphatase, NTPase), cytidine 5'-triphosphate |
| Mj0226 protein (nucleotide triphosphatase, NTPase) | Methanococcus jannaschii | guanosine 5'-triphosphate | 97.65 | 1.11 | 87.66 | pH 7.6, 80 °C | PMID 10404228 | Open record: Mj0226 protein (nucleotide triphosphatase, NTPase), guanosine 5'-triphosphate |
| Mj0226 protein (nucleotide triphosphatase, NTPase) | Methanococcus jannaschii | inosine 5'-triphosphate | 911.7 | 0.15 | 5998 | pH 7.6, 80 °C | PMID 10404228 | Open record: Mj0226 protein (nucleotide triphosphatase, NTPase), inosine 5'-triphosphate |
| Mj0226 protein (nucleotide triphosphatase, NTPase) | Methanococcus jannaschii | thymidine 5'-triphosphate | 1.77 | 0.3 | 5.9 | pH 7.6, 80 °C | PMID 10404228 | Open record: Mj0226 protein (nucleotide triphosphatase, NTPase), thymidine 5'-triphosphate |
| Mj0226 protein (nucleotide triphosphatase, NTPase) | Methanococcus jannaschii | xanthosine 5'-triphosphate | 1009 | 0.1 | 10,196 | pH 7.6, 80 °C | PMID 10404228 | Open record: Mj0226 protein (nucleotide triphosphatase, NTPase), xanthosine 5'-triphosphate |
| RdgB homolog (mouse RdgB protein) | Mus musculus | 2'-deoxy-N-6-hydroxylaminopurine triphosphate | 115 | 0.0384 | 3003 | pH 9.5, 37 °C | PMID 17090528 | Open record: RdgB homolog (mouse RdgB protein), 2'-deoxy-N-6-hydroxylaminopurine triphosphate |
| RdgB homolog (mouse RdgB protein) | Mus musculus | 2'-deoxyguanosine 5'-triphosphate | 12.4 | 0.667 | 18.6 | pH 9.5, 37 °C | PMID 17090528 | Open record: RdgB homolog (mouse RdgB protein), 2'-deoxyguanosine 5'-triphosphate |
| RdgB homolog (mouse RdgB protein) | Mus musculus | deoxyinosine triphosphate | 84 | 0.0249 | 3375 | pH 9.5, 37 °C | PMID 17090528 | Open record: RdgB homolog (mouse RdgB protein), deoxyinosine triphosphate |
| RdgB protein (deoxyribonucleoside triphosphate pyrophosphohydrolase) | Escherichia coli | 2'-deoxy-N-6-hydroxylaminopurine triphosphate | 5.7 | 0.0165 | 345 | pH 9.5, 37 °C | PMID 17090528 | Open record: RdgB protein (deoxyribonucleoside triphosphate pyrophosphohydrolase), 2'-deoxy-N-6-hydroxylaminopurine triphosphate |
| RdgB protein (deoxyribonucleoside triphosphate pyrophosphohydrolase) | Escherichia coli | 2'-deoxyguanosine 5'-triphosphate | 1.5 | 0.792 | 1.9 | pH 9.5, 37 °C | PMID 17090528 | Open record: RdgB protein (deoxyribonucleoside triphosphate pyrophosphohydrolase), 2'-deoxyguanosine 5'-triphosphate |
| RdgB protein (deoxyribonucleoside triphosphate pyrophosphohydrolase) | Escherichia coli | deoxyinosine triphosphate | 5.7 | 0.022 | 261 | pH 9.5, 37 °C | PMID 17090528 | Open record: RdgB protein (deoxyribonucleoside triphosphate pyrophosphohydrolase), deoxyinosine triphosphate |