EC 3.7.1.3: kynureninase
HydrolasesOpen in Browse
CatLog read 34 records for EC 3.7.1.3 from 5 papers, for 3 organisms. Names in these papers: kynureninase, kynureninase (HsKynase), kynureninase (PfKynase), 3-hydroxy-kynureninase (KYN) and 1 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 30 records for EC 3.7.1.3 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.7.1.3 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Substituents effects on activity of kynureninase from Homo sapiens and Pseudomonas fluorescens | Homo sapiens, Pseudomonas fluorescens | 15 |
| Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity | Homo sapiens | 8 |
| The mechanism of kynurenine hydrolysis catalyzed by kynureninase | Pseudomonas fluorescens | 7 |
| NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria | Ralstonia metallidurans | 2 |
| The roles of Ser-36, Asp-132 and Asp-201 in the reaction of Pseudomonas fluorescens Kynureninase | Pseudomonas fluorescens | 2 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| 3-hydroxy-kynureninase (KYN) | Ralstonia metallidurans | L-3-hydroxykynurenine | 2.9 | 0.04 | 74 | pH 8 | PMID 14700627 | Open record: 3-hydroxy-kynureninase (KYN), L-3-hydroxykynurenine |
| 3-hydroxy-kynureninase (KYN) | Ralstonia metallidurans | L-kynurenine | 4.52 | 0.07 | 64 | pH 8 | PMID 14700627 | Open record: 3-hydroxy-kynureninase (KYN), L-kynurenine |
| kynureninase | Homo sapiens | 3-hydroxy-DL-kynurenine | 3.5 | 0.0283 | 123 | PMID 19143568 | Open record: kynureninase, 3-hydroxy-DL-kynurenine | |
| kynureninase | Homo sapiens | L-kynurenine | 0.23 | 0.495 | 0.465 | PMID 19143568 | Open record: kynureninase, L-kynurenine | |
| kynureninasevariant H102W/N333T | Homo sapiens | L-kynurenine | 0.007 | 0.327 | 0.0214 | PMID 19143568 | Open record: kynureninase variant H102W/N333T, L-kynurenine | |
| kynureninasevariant H102W/S332G/N333T | Homo sapiens | L-kynurenine | 0.018 | 0.143 | 0.1256 | PMID 19143568 | Open record: kynureninase variant H102W/S332G/N333T, L-kynurenine | |
| kynureninasevariant N333T | Homo sapiens | 3-hydroxy-DL-kynurenine | — | — | 0.0198 | PMID 19143568 | Open record: kynureninase variant N333T, 3-hydroxy-DL-kynurenine | |
| kynureninasevariant N333T | Homo sapiens | L-kynurenine | 0.026 | 0.499 | 0.0521 | PMID 19143568 | Open record: kynureninase variant N333T, L-kynurenine | |
| kynureninasevariant S332G/N333T | Homo sapiens | 3-hydroxy-DL-kynurenine | — | — | 0.0215 | PMID 19143568 | Open record: kynureninase variant S332G/N333T, 3-hydroxy-DL-kynurenine | |
| kynureninasevariant S332G/N333T | Homo sapiens | L-kynurenine | 0.017 | 0.54 | 0.0314 | PMID 19143568 | Open record: kynureninase variant S332G/N333T, L-kynurenine | |
| kynureninase | Pseudomonas fluorescens | (2S)-2-amino-4-(2-aminophenyl)-4-hydroxybutanoic acid | — | 0.067 | — | pH 8 | PMID 118164 | Open record: kynureninase, (2S)-2-amino-4-(2-aminophenyl)-4-hydroxybutanoic acid |
| kynureninase | Pseudomonas fluorescens | (2S)-2-amino-4-oxo-4-phenylbutanoic acid | — | 0.16 | — | pH 8 | PMID 118164 | Open record: kynureninase, (2S)-2-amino-4-oxo-4-phenylbutanoic acid |
| kynureninase | Pseudomonas fluorescens | 3-hydroxy-L-kynurenine | — | 0.2 | — | pH 8 | PMID 118164 | Open record: kynureninase, 3-hydroxy-L-kynurenine |
| kynureninase | Pseudomonas fluorescens | 4-fluoro-L-kynurenine | — | 0.067 | — | pH 8 | PMID 118164 | Open record: kynureninase, 4-fluoro-L-kynurenine |
| kynureninase | Pseudomonas fluorescens | 5-fluoro-L-kynurenine | — | 0.048 | — | pH 8 | PMID 118164 | Open record: kynureninase, 5-fluoro-L-kynurenine |
| kynureninase | Pseudomonas fluorescens | L-kynurenine | — | 0.035 | — | pH 8 | PMID 118164 | Open record: kynureninase, L-kynurenine |
| kynureninase | Pseudomonas fluorescens | N'-formyl-L-kynurenine | — | 2.2 | — | pH 8 | PMID 118164 | Open record: kynureninase, N'-formyl-L-kynurenine |
| kynureninase (HsKynase) | Homo sapiens | 3,5-dibromo-L-kynurenine | 1.2 | — | 79 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (HsKynase), 3,5-dibromo-L-kynurenine |
| kynureninase (HsKynase) | Homo sapiens | 3-bromo-L-kynurenine | 1.9 | — | 4.4 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (HsKynase), 3-bromo-L-kynurenine |
| kynureninase (HsKynase) | Homo sapiens | 3-chloro-DL-kynurenine | 0.67 | — | 8.2 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (HsKynase), 3-chloro-DL-kynurenine |
| kynureninase (HsKynase) | Homo sapiens | 3-fluoro-DL-kynurenine | 0.23 | — | 2.7 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (HsKynase), 3-fluoro-DL-kynurenine |
| kynureninase (HsKynase) | Homo sapiens | 3-methyl-DL-kynurenine | 0.33 | — | 1.8 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (HsKynase), 3-methyl-DL-kynurenine |
| kynureninase (HsKynase) | Homo sapiens | 5-bromo-3-chloro-DL-kynurenine | 1.3 | — | 65 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (HsKynase), 5-bromo-3-chloro-DL-kynurenine |
| kynureninase (HsKynase) | Homo sapiens | 5-bromo-L-kynurenine | 0.63 | — | 15 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (HsKynase), 5-bromo-L-kynurenine |
| kynureninase (HsKynase) | Homo sapiens | 5-chloro-L-kynurenine | 0.47 | — | 11 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (HsKynase), 5-chloro-L-kynurenine |
| kynureninase (PfKynase) | Pseudomonas fluorescens | 3,5-dibromo-L-kynurenine | 0.23 | — | 21 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (PfKynase), 3,5-dibromo-L-kynurenine |
| kynureninase (PfKynase) | Pseudomonas fluorescens | 3-chloro-DL-kynurenine | 0.71 | — | 11 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (PfKynase), 3-chloro-DL-kynurenine |
| kynureninase (PfKynase) | Pseudomonas fluorescens | 3-fluoro-DL-kynurenine | 6.9 | — | 90 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (PfKynase), 3-fluoro-DL-kynurenine |
| kynureninase (PfKynase) | Pseudomonas fluorescens | 3-methyl-DL-kynurenine | 1.5 | — | 22 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (PfKynase), 3-methyl-DL-kynurenine |
| kynureninase (PfKynase) | Pseudomonas fluorescens | 5-bromo-3-chloro-DL-kynurenine | 0.3 | — | 22 | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (PfKynase), 5-bromo-3-chloro-DL-kynurenine |
| kynureninase (PfKynase) | Pseudomonas fluorescens | 5-bromo-L-kynurenine | 11.9 | — | 3.3 × 10³ | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (PfKynase), 5-bromo-L-kynurenine |
| kynureninase (PfKynase) | Pseudomonas fluorescens | 5-chloro-L-kynurenine | 8.7 | — | 1.8 × 10³ | pH 8, 37 °C | PMID 23791867 | Open record: kynureninase (PfKynase), 5-chloro-L-kynurenine |
| kynureninase (Pfkynase)variant S36A | Pseudomonas fluorescens | L-kynurenine | 0.069 | 0.0035 | 20 | pH 8, 37 °C | PMID 31100408 | Open record: kynureninase (Pfkynase) variant S36A, L-kynurenine |
| kynureninase (Pfkynase)variant S36A | Pseudomonas fluorescens | O-benzoyl-L-serine | 1.7 | 0.071 | 24 | pH 8, 37 °C | PMID 31100408 | Open record: kynureninase (Pfkynase) variant S36A, O-benzoyl-L-serine |