CatLogenzyme kinetics catalog

EC 4.1.2.25: dihydroneopterin aldolase

LyasesOpen in Browse

CatLog read 13 records for EC 4.1.2.25 from 3 papers, for 3 organisms. Names in these papers: 7,8-dihydroneopterin aldolase (DHNA, MptD), dihydroneopterin aldolase (FolB), dihydroneopterin aldolase (MtDHNA).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 23 records for EC 4.1.2.25 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.1.2.25 in Browse.

Papers

PaperOrganismsRecords
Biochemical characterization of a dihydroneopterin aldolase used for methanopterin biosynthesis in methanogensMethanocaldococcus jannaschii7
Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolaseHaemophilus influenzae4
One substrate, five products: reactions catalyzed by the dihydroneopterin aldolase from Mycobacterium tuberculosisMycobacterium tuberculosis2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
7,8-dihydroneopterin aldolase (DHNA, MptD)Methanocaldococcus jannaschiiD-7,8-dihydroneopterin0.070.06451.1pH 7.6, 25 °CPMID 24982305Open
7,8-dihydroneopterin aldolase (DHNA, MptD)Methanocaldococcus jannaschiiD-7,8-dihydroneopterin10.0099100pH 7.6, 70 °CPMID 24982305Open
7,8-dihydroneopterin aldolase (DHNA, MptD)variant E25QMethanocaldococcus jannaschiiD-7,8-dihydroneopterin0.68——pH 7.6, 70 °CPMID 24982305Open
7,8-dihydroneopterin aldolase (DHNA, MptD)variant H35NMethanocaldococcus jannaschiiD-7,8-dihydroneopterin0.0550.0212.6pH 7.6, 70 °CPMID 24982305Open
7,8-dihydroneopterin aldolase (DHNA, MptD)variant Q61AMethanocaldococcus jannaschiiD-7,8-dihydroneopterin0.0480.00845.7pH 7.6, 70 °CPMID 24982305Open
7,8-dihydroneopterin aldolase (DHNA, MptD)variant Y111FMethanocaldococcus jannaschiiD-7,8-dihydroneopterin0.640.01158pH 7.6, 70 °CPMID 24982305Open
7,8-dihydroneopterin aldolase (DHNA, MptD)variant Y78FMethanocaldococcus jannaschiiD-7,8-dihydroneopterin0.0540.031.8pH 7.6, 70 °CPMID 24982305Open
dihydroneopterin aldolase (FolB)Haemophilus influenzae7,8-dihydro-D-neopterincleavage to 6-hydroxymethyl-7,8-dihydropterin (6-HMP)—0.021—pH 8, 37 °CPMID 9651328Open
dihydroneopterin aldolase (FolB)Haemophilus influenzae7,8-dihydro-D-neopterinepimerization to 7,8-dihydromonapterin (H2Mona)—0.043—pH 8, 37 °CPMID 9651328Open
dihydroneopterin aldolase (FolB)Haemophilus influenzae7,8-dihydro-L-monapterincleavage to 6-hydroxymethyl-7,8-dihydropterin (6-HMP)—0.016—pH 8, 37 °CPMID 9651328Open
dihydroneopterin aldolase (FolB)Haemophilus influenzae7,8-dihydro-L-monapterinepimerization to 7,8-dihydroneopterin (H2Neo)—0.019—pH 8, 37 °CPMID 9651328Open
dihydroneopterin aldolase (MtDHNA)Mycobacterium tuberculosis7,8-dihydromonapterin0.0061.54 × 10⁻⁴38pH 7, 25 °CPMID 23150985Open
dihydroneopterin aldolase (MtDHNA)Mycobacterium tuberculosis7,8-dihydroneopterin0.00541.65 × 10⁻⁴36pH 7, 25 °CPMID 23150985Open