CatLogenzyme kinetics catalog

EC 4.1.3.16: 4-Hydroxy-2-oxoglutarate aldolase

LyasesOpen in Browse

CatLog read 17 records for EC 4.1.3.16 from 3 papers, for 3 organisms. Names in these papers: 4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA), 2-keto-4-hydroxyglutarate aldolase, pyruvate-glyoxylate condensing enzyme (forms γ-hydroxy-α-ketoglutarate).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 18 records for EC 4.1.3.16 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.1.3.16 in Browse.

Papers

PaperOrganismsRecords
Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluriaHomo sapiens10
2-Keto-4-hydroxyglutarate aldolase: purification and characterization of the homogeneous enzyme from bovine kidneyBos taurus4
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATERattus norvegicus3

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
2-keto-4-hydroxyglutarate aldolaseBos taurusD-2-keto-4-hydroxyglutarate—0.031—pH 8.3, 37 °CPMID 1587831Open
2-keto-4-hydroxyglutarate aldolaseBos taurusDL-2-keto-4-hydroxyglutarate—0.026—pH 8.3, 37 °CPMID 1587831Open
2-keto-4-hydroxyglutarate aldolaseBos taurusL-2-keto-4-hydroxyglutarate—0.024—pH 8.3, 37 °CPMID 1587831Open
2-keto-4-hydroxyglutarate aldolaseBos taurusoxaloacetate—0.164—pH 8.3, 37 °CPMID 1587831Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)Homo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)6.10.011555pH 8.5, 37 °CPMID 21998747Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)variant N78AHomo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)7.60.066115pH 8.5, 37 °CPMID 21998747Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)variant N78QHomo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)6.20.28122pH 8.5, 37 °CPMID 21998747Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)variant N78THomo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)40.016250pH 8.5, 37 °CPMID 21998747Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)variant S198AHomo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)2.40.04455pH 8.5, 37 °CPMID 21998747Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)variant S198THomo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)7.80.077101pH 8.5, 37 °CPMID 21998747Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)variant S77AHomo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)2.50.08430pH 8.5, 37 °CPMID 21998747Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)variant S77THomo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)0.80.05814pH 8.5, 37 °CPMID 21998747Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)variant S77VHomo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)1.20.08215pH 8.5, 37 °CPMID 21998747Open
4-hydroxy-2-oxoglutarate aldolase (human HOGA, hHOGA)variant Y140FHomo sapiens4-hydroxy-2-oxoglutarate (racemic mixture of R- and S-forms)5.20.008650pH 8.5, 37 °CPMID 21998747Open
pyruvate-glyoxylate condensing enzyme (forms γ-hydroxy-α-ketoglutarate)Rattus norvegicusglyoxylate—0.43—pH 7.5, 37 °CPMID 14089442Open
pyruvate-glyoxylate condensing enzyme (forms γ-hydroxy-α-ketoglutarate)Rattus norvegicuspyruvate—10—pH 7.5, 37 °CPMID 14089442Open
pyruvate-glyoxylate condensing enzyme (forms γ-hydroxy-α-ketoglutarate)Rattus norvegicusγ-hydroxy-α-ketoglutarate—1.33—pH 7.5, 37 °CPMID 14089442Open