EC 4.1.3.18: acetolactate synthase
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CatLog read 10 records for EC 4.1.3.18 from 2 papers, for 1 organism. Names in these papers: acetohydroxyacid synthase catalytic subunit, acetohydroxyacid synthase (AHAS) catalytic subunit.
EC 4.1.3.18 is no longer current; BRENDA: “transferred to EC 2.2.1.6”.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Structural and functional significance of the highly-conserved residues in Mycobacterium tuberculosis acetohydroxyacid synthase | Mycobacterium tuberculosis | 6 |
| Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase | Mycobacterium tuberculosis | 4 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| acetohydroxyacid synthase (AHAS) catalytic subunit | Mycobacterium tuberculosis | pyruvate | 3.196 | 2.76 | 1.158 | pH 7.5, 37 °C | PMID 23931689 | Open record: acetohydroxyacid synthase (AHAS) catalytic subunit, pyruvate |
| acetohydroxyacid synthase (AHAS) catalytic subunitvariant P126A | Mycobacterium tuberculosis | pyruvate | 0.165 | 6.04 | 0.02722 | pH 7.5, 37 °C | PMID 23931689 | Open record: acetohydroxyacid synthase (AHAS) catalytic subunit variant P126A, pyruvate |
| acetohydroxyacid synthase (AHAS) catalytic subunitvariant P126T | Mycobacterium tuberculosis | pyruvate | 0.166 | 807.7 | 2.05 × 10⁻⁴ | pH 7.5, 37 °C | PMID 23931689 | Open record: acetohydroxyacid synthase (AHAS) catalytic subunit variant P126T, pyruvate |
| acetohydroxyacid synthase (AHAS) catalytic subunitvariant P126V | Mycobacterium tuberculosis | pyruvate | 0.164 | 466.7 | 3.52 × 10⁻⁴ | pH 7.5, 37 °C | PMID 23931689 | Open record: acetohydroxyacid synthase (AHAS) catalytic subunit variant P126V, pyruvate |
| acetohydroxyacid synthase catalytic subunitvariant E85A | Mycobacterium tuberculosis | pyruvate | 0.0026 | — | — | pH 7.5, 37 °C | PMID 24731825 | Open record: acetohydroxyacid synthase catalytic subunit variant E85A, pyruvate |
| acetohydroxyacid synthase catalytic subunitvariant E85D | Mycobacterium tuberculosis | pyruvate | 0.0712 | — | — | pH 7.5, 37 °C | PMID 24731825 | Open record: acetohydroxyacid synthase catalytic subunit variant E85D, pyruvate |
| acetohydroxyacid synthase catalytic subunitvariant E85Q | Mycobacterium tuberculosis | pyruvate | 0.0384 | — | — | pH 7.5, 37 °C | PMID 24731825 | Open record: acetohydroxyacid synthase catalytic subunit variant E85Q, pyruvate |
| acetohydroxyacid synthase catalytic subunitvariant H84A | Mycobacterium tuberculosis | pyruvate | 0.046 | 0.15 | 0.31 calc. | pH 7.5, 37 °C | PMID 24731825 | Open record: acetohydroxyacid synthase catalytic subunit variant H84A, pyruvate |
| acetohydroxyacid synthase catalytic subunitvariant H84T | Mycobacterium tuberculosis | pyruvate | 0.212 | 0.2133 | 0.994 calc. | pH 7.5, 37 °C | PMID 24731825 | Open record: acetohydroxyacid synthase catalytic subunit variant H84T, pyruvate |
| acetohydroxyacid synthase catalytic subunitvariant Q86A | Mycobacterium tuberculosis | pyruvate | 0.25 | 0.1413 | 1.8 calc. | pH 7.5, 37 °C | PMID 24731825 | Open record: acetohydroxyacid synthase catalytic subunit variant Q86A, pyruvate |