EC 4.1.99.1: tryptophanase
LyasesOpen in Browse
CatLog read 69 records for EC 4.1.99.1 from 5 papers, for 5 organisms. Names in these papers: tryptophan indole-lyase (tryptophanase, Trpase), tryptophanase (tryptophan indole-lyase), tryptophan indole-lyase (PpTrpase, PBPRA2532), tryptophan indole-lyase (Trpase) and 7 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 51 records for EC 4.1.99.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.1.99.1 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Role of aspartate-133 and histidine-458 in the mechanism of tryptophan indole-lyase from Proteus vulgaris | Proteus vulgaris | 31 |
| Tryptophanase Mining and Characterization toward the Biological Production of Indole Derivatives | Aeromonas sobria, Escherichia coli and 1 more | 18 |
| Tryptophanase from Proteus vulgaris: the conformational rearrangement in the active site, induced by the mutation of Tyrosine 72 to phenylalanine, and its mechanistic consequences | Proteus vulgaris | 8 |
| Properties of tryptophan indole-lyase from a piezophilic bacterium, Photobacterium profundum SS9 | Escherichia coli, Photobacterium profundum | 7 |
| Hidden Activities of Tyrosine Phenol-Lyase and Tryptophan Indole-Lyase: Recombinant PLP-Dependent C-C Lyases as New Biocatalysts for Antimicrobial Thiosulfinate Generation | Proteus vulgaris | 5 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| tryptophan indole-lyase (EcTrpase) | Escherichia coli | beta-chloro-L-alanine | 12.4 | — | 2.4 | pH 8, 25 °C | PMID 21081107 | Open record: tryptophan indole-lyase (EcTrpase), beta-chloro-L-alanine |
| tryptophan indole-lyase (PpTrpase, PBPRA2532) | Photobacterium profundum | beta-chloro-L-alanine | 3 | — | 0.77 | pH 8, 25 °C | PMID 21081107 | Open record: tryptophan indole-lyase (PpTrpase, PBPRA2532), beta-chloro-L-alanine |
| tryptophan indole-lyase (PpTrpase, PBPRA2532) | Photobacterium profundum | L-tryptophan | 2.5 | — | 7.6 | pH 8, 25 °C | PMID 21081107 | Open record: tryptophan indole-lyase (PpTrpase, PBPRA2532), L-tryptophan |
| tryptophan indole-lyase (PpTrpase, PBPRA2532) | Photobacterium profundum | S-(o-nitrophenyl)-L-cysteine | 13.9 | — | 29 | pH 8, 25 °C | PMID 21081107 | Open record: tryptophan indole-lyase (PpTrpase, PBPRA2532), S-(o-nitrophenyl)-L-cysteine |
| tryptophan indole-lyase (PpTrpase, PBPRA2532) | Photobacterium profundum | S-benzyl-L-cysteine | 1.1 | — | 11 | pH 8, 25 °C | PMID 21081107 | Open record: tryptophan indole-lyase (PpTrpase, PBPRA2532), S-benzyl-L-cysteine |
| tryptophan indole-lyase (PpTrpase, PBPRA2532) | Photobacterium profundum | S-ethyl-L-cysteine | 0.4 | — | 0.28 | pH 8, 25 °C | PMID 21081107 | Open record: tryptophan indole-lyase (PpTrpase, PBPRA2532), S-ethyl-L-cysteine |
| tryptophan indole-lyase (PpTrpase, PBPRA2532) | Photobacterium profundum | S-methyl-L-cysteine | 0.2 | — | 0.06 | pH 8, 25 °C | PMID 21081107 | Open record: tryptophan indole-lyase (PpTrpase, PBPRA2532), S-methyl-L-cysteine |
| tryptophan indole-lyase (Trpase) | Proteus vulgaris | S-allyl-L-cysteine sulfoxide | 10.4 | 8.6 | 1.2 | pH 8, 37 °C | PMID 41754831 | Open record: tryptophan indole-lyase (Trpase), S-allyl-L-cysteine sulfoxide |
| tryptophan indole-lyase (Trpase) | Proteus vulgaris | S-benzyl-L-cysteine sulfoxide | 21.1 | 2.3 | 9.2 | pH 8, 37 °C | PMID 41754831 | Open record: tryptophan indole-lyase (Trpase), S-benzyl-L-cysteine sulfoxide |
| tryptophan indole-lyase (Trpase) | Proteus vulgaris | S-ethyl-L-cysteine sulfoxide | 8.9 | 5.1 | 1.7 | pH 8, 37 °C | PMID 41754831 | Open record: tryptophan indole-lyase (Trpase), S-ethyl-L-cysteine sulfoxide |
| tryptophan indole-lyase (Trpase) | Proteus vulgaris | S-methyl-L-cysteine sulfoxide | 4.1 | 3.9 | 0.11 | pH 8, 37 °C | PMID 41754831 | Open record: tryptophan indole-lyase (Trpase), S-methyl-L-cysteine sulfoxide |
| tryptophan indole-lyase (Trpase) | Proteus vulgaris | S-propyl-L-cysteine sulfoxide | 11.4 | 3.1 | 3.7 | pH 8, 37 °C | PMID 41754831 | Open record: tryptophan indole-lyase (Trpase), S-propyl-L-cysteine sulfoxide |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | H2-L-Trp | 1.66 | 0.18 | 9.32 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), H2-L-Trp |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | L-serine | 1.83 | 50.9 | 0.0359 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), L-serine |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | L-tryptophan | — | 0.28 | — | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | L-tryptophan | 6.29 | — | — | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | L-tryptophan | — | — | 22.5 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | L-tryptophanin D2O (solvent isotope effect) | — | 0.26 | — | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | L-tryptophanin D2O (solvent isotope effect) | 1.73 | — | — | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | L-tryptophanin D2O (solvent isotope effect) | — | — | 6.65 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | S-(o-nitrophenyl)-L-cysteine | 33.35 | 0.18 | 185 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), S-(o-nitrophenyl)-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | S-benzyl-L-cysteine | 1.95 | 0.8 | 2.44 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), S-benzyl-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | S-ethyl-L-cysteine | 3.59 | 3.17 | 1.13 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), S-ethyl-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | S-methyl-L-cysteine | 4.1 | 16.8 | 0.238 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), S-methyl-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase) | Proteus vulgaris | β-chloro-L-alanine | 8.41 | 9.36 | 0.898 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase), β-chloro-L-alanine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant D133A | Proteus vulgaris | S-(o-nitrophenyl)-L-cysteine | 1.4 | 0.01 | 140 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant D133A, S-(o-nitrophenyl)-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant D133A | Proteus vulgaris | S-benzyl-L-cysteine | 0.87 | 0.01 | 87 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant D133A, S-benzyl-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant D133A | Proteus vulgaris | S-ethyl-L-cysteine | 0.21 | 0.03 | 7 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant D133A, S-ethyl-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant D133A | Proteus vulgaris | S-methyl-L-cysteine | 0.35 | 0.19 | 1.84 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant D133A, S-methyl-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant D133A | Proteus vulgaris | β-chloro-L-alanine | 10.8 | 4.6 | 2.35 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant D133A, β-chloro-L-alanine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | H2-L-Trp | 0.05 | 0.76 | 0.065 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, H2-L-Trp |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | L-serine | 1.3 | 7.85 | 0.165 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, L-serine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | L-tryptophan | — | 1.15 | — | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | L-tryptophan | 0.11 | — | — | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | L-tryptophan | — | — | 0.095 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | L-tryptophanin D2O (solvent isotope effect) | — | 1 | — | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | L-tryptophanin D2O (solvent isotope effect) | 0.04 | — | — | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | L-tryptophanin D2O (solvent isotope effect) | — | — | 0.04 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, L-tryptophan |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | S-(o-nitrophenyl)-L-cysteine | 31.8 | 0.1 | 318 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, S-(o-nitrophenyl)-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | S-benzyl-L-cysteine | 10.9 | 0.096 | 113 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, S-benzyl-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | S-ethyl-L-cysteine | 6.41 | 0.42 | 15.2 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, S-ethyl-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | S-methyl-L-cysteine | 6.03 | 2.32 | 2.59 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, S-methyl-L-cysteine |
| tryptophan indole-lyase (tryptophanase, Trpase)variant H458A | Proteus vulgaris | β-chloro-L-alanine | 23.3 | 5.6 | 4.16 | pH 8, 30 °C | PMID 14503866 | Open record: tryptophan indole-lyase (tryptophanase, Trpase) variant H458A, β-chloro-L-alanine |
| tryptophanase (tryptophan indole-lyase)variant Y72F | Proteus vulgaris | 3-chloro-L-alanine | 0.0932 | 6.15 | 0.0151 | pH 7.8, 30 °C | PMID 16455316 | Open record: tryptophanase (tryptophan indole-lyase) variant Y72F, 3-chloro-L-alanine |
| tryptophanase (tryptophan indole-lyase)variant Y72F | Proteus vulgaris | L-alanine | 4.5 × 10⁻⁶ | — | — | pH 7.8, 25 °C | PMID 16455316 | Open record: tryptophanase (tryptophan indole-lyase) variant Y72F, L-alanine |
| tryptophanase (tryptophan indole-lyase)variant Y72F | Proteus vulgaris | L-serine | 0.0303 | 4.64 | 0.00653 | pH 7.8, 30 °C | PMID 16455316 | Open record: tryptophanase (tryptophan indole-lyase) variant Y72F, L-serine |
| tryptophanase (tryptophan indole-lyase)variant Y72F | Proteus vulgaris | L-tryptophan | 4 × 10⁻⁵ | 0.12 | 0.033 | pH 7.8, 30 °C | PMID 16455316 | Open record: tryptophanase (tryptophan indole-lyase) variant Y72F, L-tryptophan |
| tryptophanase (tryptophan indole-lyase)variant Y72F | Proteus vulgaris | S-(o-nitrophenyl)-L-cysteine | 0.423 | 0.18 | 2.32 | pH 7.8, 30 °C | PMID 16455316 | Open record: tryptophanase (tryptophan indole-lyase) variant Y72F, S-(o-nitrophenyl)-L-cysteine |
| tryptophanase (tryptophan indole-lyase)variant Y72F | Proteus vulgaris | S-benzyl-L-cysteine | 4.6 × 10⁻⁴ | 0.15 | 0.00306 | pH 7.8, 30 °C | PMID 16455316 | Open record: tryptophanase (tryptophan indole-lyase) variant Y72F, S-benzyl-L-cysteine |
| tryptophanase (tryptophan indole-lyase)variant Y72F | Proteus vulgaris | S-ethyl-L-cysteine | 0.035 | 0.81 | 0.0431 | pH 7.8, 30 °C | PMID 16455316 | Open record: tryptophanase (tryptophan indole-lyase) variant Y72F, S-ethyl-L-cysteine |
| tryptophanase (tryptophan indole-lyase)variant Y72F | Proteus vulgaris | S-methyl-L-cysteine | 0.0051 | 0.18 | 0.0277 | pH 7.8, 30 °C | PMID 16455316 | Open record: tryptophanase (tryptophan indole-lyase) variant Y72F, S-methyl-L-cysteine |
| tryptophanase AsoTIL | Aeromonas sobria | L-tryptophan | 2.33 | 0.73 | 3.192 | pH 7, 30 °C | PMID 41835499 | Open record: tryptophanase AsoTIL, L-tryptophan |
| tryptophanase AsoTIL | Aeromonas sobria | L-tryptophan | 2.09 | 0.15 | 13.9 | pH 8.2, 40 °C | PMID 41835499 | Open record: tryptophanase AsoTIL, L-tryptophan |
| tryptophanase AsoTIL | Aeromonas sobria | L-tryptophan | 7.03 | 0.13 | 54.08 | pH 8.5, 65 °C | PMID 41835499 | Open record: tryptophanase AsoTIL, L-tryptophan |
| tryptophanase EcoTIL | Escherichia coli | L-tryptophan | 2.12 | 0.2 | 10.6 | pH 7, 30 °C | PMID 41835499 | Open record: tryptophanase EcoTIL, L-tryptophan |
| tryptophanase EcoTIL | Escherichia coli | L-tryptophan | 2.84 | 0.13 | 21.85 | pH 8.2, 40 °C | PMID 41835499 | Open record: tryptophanase EcoTIL, L-tryptophan |
| tryptophanase EcoTIL | Escherichia coli | L-tryptophan | 2.61 | 0.18 | 14.5 | pH 8, 45 °C | PMID 41835499 | Open record: tryptophanase EcoTIL, L-tryptophan |
| tryptophanase PreTIL | — | L-tryptophan | 3.26 | 0.47 | 6.936 | pH 7, 30 °C | PMID 41835499 | Open record: tryptophanase PreTIL, L-tryptophan |
| tryptophanase PreTIL | — | L-tryptophan | 4.54 | 0.2 | 22.7 | pH 8.2, 40 °C | PMID 41835499 | Open record: tryptophanase PreTIL, L-tryptophan |
| tryptophanase PreTIL | — | L-tryptophan | 4 | 0.3 | 13.3 | pH 8.5, 50 °C | PMID 41835499 | Open record: tryptophanase PreTIL, L-tryptophan |
| tryptophanase PvuTIL | — | L-tryptophan | 2.11 | 0.54 | 3.907 | pH 7, 30 °C | PMID 41835499 | Open record: tryptophanase PvuTIL, L-tryptophan |
| tryptophanase PvuTIL | — | L-tryptophan | 2.64 | 0.23 | 11.48 | pH 8.2, 40 °C | PMID 41835499 | Open record: tryptophanase PvuTIL, L-tryptophan |
| tryptophanase PvuTIL | — | L-tryptophan | 4.13 | 0.21 | 19.7 | pH 8, 50 °C | PMID 41835499 | Open record: tryptophanase PvuTIL, L-tryptophan |
| tryptophanase TtiTIL | — | L-tryptophan | 1.49 | 0.69 | 2.159 | pH 7, 30 °C | PMID 41835499 | Open record: tryptophanase TtiTIL, L-tryptophan |
| tryptophanase TtiTIL | — | L-tryptophan | 1.69 | 0.57 | 2.965 | pH 8.2, 40 °C | PMID 41835499 | Open record: tryptophanase TtiTIL, L-tryptophan |
| tryptophanase TtiTIL | — | L-tryptophan | 1.58 | 0.37 | 4.27 | pH 8, 45 °C | PMID 41835499 | Open record: tryptophanase TtiTIL, L-tryptophan |
| tryptophanase VchTIL | Vibrio cholerae | L-tryptophan | 4.51 | 0.84 | 5.369 | pH 7, 30 °C | PMID 41835499 | Open record: tryptophanase VchTIL, L-tryptophan |
| tryptophanase VchTIL | Vibrio cholerae | L-tryptophan | 4.38 | 0.37 | 11.84 | pH 8.2, 40 °C | PMID 41835499 | Open record: tryptophanase VchTIL, L-tryptophan |
| tryptophanase VchTIL | Vibrio cholerae | L-tryptophan | 5.95 | 0.17 | 35 | pH 8.9, 40 °C | PMID 41835499 | Open record: tryptophanase VchTIL, L-tryptophan |