EC 5.1.1.1: alanine racemase

IsomerasesOpen in Browse

CatLog read 81 records for EC 5.1.1.1 from 8 papers, for 9 organisms. Names in these papers: alanine racemase (CPAlr), alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1), alanine racemase, alanine racemase AlrTt (MBAlr1) and 4 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 152 records for EC 5.1.1.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 5.1.1.1 in Browse.

Papers

Papers with records for EC 5.1.1.1
Paper	Organisms	Records
Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis	Escherichia coli	18
Biochemical characterization and mutational analysis of alanine racemase from Clostridium perfringens	Clostridium perfringens	18
Crystal Structure of a Thermostable Alanine Racemase from Thermoanaerobacter tengcongensis MB4 Reveals the Role of Gln360 in Substrate Selection	Thermoanaerobacter tengcongensis	12
Lysine racemase from a lactic acid bacterium, Oenococcus oeni: structural basis of substrate specificity	Geobacillus stearothermophilus	10
Primordial-like enzymes from bacteria with reduced genomes	Thermotoga maritima, Wolbachia endosymbiont of Drosophila melanogaster	9
Alanine racemase free energy profiles from global analyses of progress curves	Bacillus stearothermophilus	6
A novel assay method for an amino acid racemase reaction based on circular dichroism	Escherichia coli, Streptomyces lavendulae	6
Structural basis for the broad specificity of a new family of amino-acid racemases	Vibrio cholerae	2

Records

Records for EC 5.1.1.1 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
alanine racemase	Bacillus stearothermophilus	D-alanine	180	1.6	110 calc.	pH 6.9, 25 °C	PMID 15198593	Open record: alanine racemase, D-alanine
alanine racemase	Bacillus stearothermophilus	D-alaninekcat calculated from the enzyme concentration	160	1.5	110 calc.	pH 6.9, 25 °C	PMID 15198593	Open record: alanine racemase, D-alanine
alanine racemase	Bacillus stearothermophilus	D-alanine	1 × 10³	2.8	360 calc.	pH 8.9, 25 °C	PMID 15198593	Open record: alanine racemase, D-alanine
alanine racemase	Bacillus stearothermophilus	L-alanine	210	2.1	100 calc.	pH 6.9, 25 °C	PMID 15198593	Open record: alanine racemase, L-alanine
alanine racemase	Bacillus stearothermophilus	L-alaninekcat calculated from the enzyme concentration	230	1.9	120 calc.	pH 6.9, 25 °C	PMID 15198593	Open record: alanine racemase, L-alanine
alanine racemase	Bacillus stearothermophilus	L-alanine	1.9 × 10³	4.5	420 calc.	pH 8.9, 25 °C	PMID 15198593	Open record: alanine racemase, L-alanine
alanine racemase	Geobacillus stearothermophilus	D-alanine	1.02 × 10³	2.8	370	pH 8, 37 °C	PMID 23035128	Open record: alanine racemase, D-alanine
alanine racemase	Geobacillus stearothermophilus	L-alanine	1.53 × 10³	5.1	300	pH 8, 37 °C	PMID 23035128	Open record: alanine racemase, L-alanine
alanine racemasevariant I222T	Geobacillus stearothermophilus	D-alanine	980	2.6	380	pH 8, 37 °C	PMID 23035128	Open record: alanine racemase variant I222T, D-alanine
alanine racemasevariant I222T	Geobacillus stearothermophilus	L-alanine	1.42 × 10³	4.7	300	pH 8, 37 °C	PMID 23035128	Open record: alanine racemase variant I222T, L-alanine
alanine racemasevariant I222T/Y354W	Geobacillus stearothermophilus	D-alanine	630	4	158	pH 8, 37 °C	PMID 23035128	Open record: alanine racemase variant I222T/Y354W, D-alanine
alanine racemasevariant I222T/Y354W	Geobacillus stearothermophilus	D-lysine	2.5	18	0.138	pH 8	PMID 23035128	Open record: alanine racemase variant I222T/Y354W, D-lysine
alanine racemasevariant I222T/Y354W	Geobacillus stearothermophilus	L-alanine	1.13 × 10³	8.3	137	pH 8, 37 °C	PMID 23035128	Open record: alanine racemase variant I222T/Y354W, L-alanine
alanine racemasevariant I222T/Y354W	Geobacillus stearothermophilus	L-lysine	4.2	32	0.13	pH 8	PMID 23035128	Open record: alanine racemase variant I222T/Y354W, L-lysine
alanine racemasevariant Y354W	Geobacillus stearothermophilus	D-alanine	520	2.3	220	pH 8, 37 °C	PMID 23035128	Open record: alanine racemase variant Y354W, D-alanine
alanine racemasevariant Y354W	Geobacillus stearothermophilus	L-alanine	1.13 × 10³	4.5	250	pH 8, 37 °C	PMID 23035128	Open record: alanine racemase variant Y354W, L-alanine
alanine racemase (ALR)	Escherichia coli	D-alanine	28	0.25	110 calc.	pH 8.2, 37 °C	PMID 15796715	Open record: alanine racemase (ALR), D-alanine
alanine racemase (ALR)	Escherichia coli	L-alanine	27.7	0.29	95 calc.	pH 8.2, 37 °C	PMID 15796715	Open record: alanine racemase (ALR), L-alanine
alanine racemase (ALR)	Streptomyces lavendulae	D-alanine	63	0.4	160 calc.	pH 8.2, 37 °C	PMID 15796715	Open record: alanine racemase (ALR), D-alanine
alanine racemase (ALR)	Streptomyces lavendulae	D-serine	5.5	10	0.55 calc.	pH 8.2, 37 °C	PMID 15796715	Open record: alanine racemase (ALR), D-serine
alanine racemase (ALR)	Streptomyces lavendulae	L-alanine	55	0.4	140 calc.	pH 8.2, 37 °C	PMID 15796715	Open record: alanine racemase (ALR), L-alanine
alanine racemase (ALR)	Streptomyces lavendulae	L-serine	13	27	0.49 calc.	pH 8.2, 37 °C	PMID 15796715	Open record: alanine racemase (ALR), L-serine
alanine racemase (CPAlr)	Clostridium perfringens	D-alanine	8.7	10.5	0.8	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr), D-alanine
alanine racemase (CPAlr)	Clostridium perfringens	L-alanine	17.2	19.1	0.9	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr), L-alanine
alanine racemase (CPAlr)variant D171A	Clostridium perfringens	D-alanine	2	20.1	0.1	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant D171A, D-alanine
alanine racemase (CPAlr)variant D171A	Clostridium perfringens	L-alanine	7.8	41.4	0.2	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant D171A, L-alanine
alanine racemase (CPAlr)variant D171A/Y359H	Clostridium perfringens	D-alanine	3.4	38.2	0.1	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant D171A/Y359H, D-alanine
alanine racemase (CPAlr)variant D171A/Y359H	Clostridium perfringens	L-alanine	4.9	20.8	0.2	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant D171A/Y359H, L-alanine
alanine racemase (CPAlr)variant D171S	Clostridium perfringens	D-alanine	1.4	10.8	0.1	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant D171S, D-alanine
alanine racemase (CPAlr)variant D171S	Clostridium perfringens	L-alanine	3.6	12.4	0.3	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant D171S, L-alanine
alanine racemase (CPAlr)variant S170A	Clostridium perfringens	D-alanine	6.3	11.6	0.5	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant S170A, D-alanine
alanine racemase (CPAlr)variant S170A	Clostridium perfringens	L-alanine	12.6	19	0.7	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant S170A, L-alanine
alanine racemase (CPAlr)variant S170A/Y359A	Clostridium perfringens	D-alanine	4	16.6	0.2	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant S170A/Y359A, D-alanine
alanine racemase (CPAlr)variant S170A/Y359A	Clostridium perfringens	L-alanine	5.6	24.3	0.2	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant S170A/Y359A, L-alanine
alanine racemase (CPAlr)variant S170A/Y359H	Clostridium perfringens	D-alanine	3.2	8.6	0.4	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant S170A/Y359H, D-alanine
alanine racemase (CPAlr)variant S170A/Y359H	Clostridium perfringens	L-alanine	4.7	12.8	0.4	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant S170A/Y359H, L-alanine
alanine racemase (CPAlr)variant Y359A	Clostridium perfringens	D-alanine	6.8	19.6	0.4	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant Y359A, D-alanine
alanine racemase (CPAlr)variant Y359A	Clostridium perfringens	L-alanine	16.4	68.7	0.2	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant Y359A, L-alanine
alanine racemase (CPAlr)variant Y359H	Clostridium perfringens	D-alanine	4	13.4	0.3	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant Y359H, D-alanine
alanine racemase (CPAlr)variant Y359H	Clostridium perfringens	L-alanine	12	36.3	0.3	pH 8, 40 °C	PMID 30826314	Open record: alanine racemase (CPAlr) variant Y359H, L-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)	Escherichia coli	D-alanine	5.78	0.311	18.6 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1), D-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)	Escherichia coli	L-alanine	53.98	1.008	53.55 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1), L-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant D164A	Escherichia coli	D-alanine	4.47	0.615	7.26 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant D164A, D-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant D164A	Escherichia coli	L-alanine	41.82	3.03	13.8 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant D164A, L-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant D164K	Escherichia coli	D-alanine	0.33	0.604	0.55 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant D164K, D-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant D164K	Escherichia coli	L-alanine	2.8	3.603	0.78 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant D164K, L-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E165A	Escherichia coli	D-alanine	4	0.592	6.8 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E165A, D-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E165A	Escherichia coli	L-alanine	22.47	1.562	14.38 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E165A, L-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E165K	Escherichia coli	D-alanine	1.32	0.528	2.50 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E165K, D-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E165K	Escherichia coli	L-alanine	16.72	2.057	8.127 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E165K, L-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E221A	Escherichia coli	D-alanine	6.82	0.439	15.5 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E221A, D-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E221A	Escherichia coli	L-alanine	70.92	1.516	46.78 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E221A, L-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E221K	Escherichia coli	D-alanine	6.35	0.402	15.8 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E221K, D-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E221K	Escherichia coli	L-alanine	68.23	1.993	34.24 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E221K, L-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E221P	Escherichia coli	D-alanine	7.62	0.513	14.8 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E221P, D-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant E221P	Escherichia coli	L-alanine	67.07	1.401	47.87 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant E221P, L-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant P219A	Escherichia coli	D-alanine	5.27	0.304	17.3 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant P219A, D-alanine
alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1)variant P219A	Escherichia coli	L-alanine	51.77	1.049	49.35 calc.	pH 8, 30 °C	PMID 18434499	Open record: alanine racemase (EcAlr, biosynthetic alr-encoded alanine racemase 1) variant P219A, L-alanine
alanine racemase AlrTt (MBAlr1)	Thermoanaerobacter tengcongensis	D-alanine	96.86	381.2	0.25	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1), D-alanine
alanine racemase AlrTt (MBAlr1)	Thermoanaerobacter tengcongensis	L-alanine	212.4	780.2	0.27	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1), L-alanine
alanine racemase AlrTt (MBAlr1)variant Q360I	Thermoanaerobacter tengcongensis	D-alanine	225.0	110.3	2.04	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant Q360I, D-alanine
alanine racemase AlrTt (MBAlr1)variant Q360I	Thermoanaerobacter tengcongensis	L-alanine	286.6	136	2.11	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant Q360I, L-alanine
alanine racemase AlrTt (MBAlr1)variant Q360W	Thermoanaerobacter tengcongensis	D-alanine	633.5	216.1	2.93	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant Q360W, D-alanine
alanine racemase AlrTt (MBAlr1)variant Q360W	Thermoanaerobacter tengcongensis	L-alanine	612.4	176.1	3.48	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant Q360W, L-alanine
alanine racemase AlrTt (MBAlr1)variant Q360Y	Thermoanaerobacter tengcongensis	D-alanine	251.2	52.03	4.83	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant Q360Y, D-alanine
alanine racemase AlrTt (MBAlr1)variant Q360Y	Thermoanaerobacter tengcongensis	L-alanine	431.5	87.81	4.91	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant Q360Y, L-alanine
alanine racemase AlrTt (MBAlr1)variant Q360Y/S173D	Thermoanaerobacter tengcongensis	D-alanine	133.1	58.48	2.27	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant Q360Y/S173D, D-alanine
alanine racemase AlrTt (MBAlr1)variant Q360Y/S173D	Thermoanaerobacter tengcongensis	L-alanine	246.5	83.1	2.97	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant Q360Y/S173D, L-alanine
alanine racemase AlrTt (MBAlr1)variant S173D	Thermoanaerobacter tengcongensis	D-alanine	32.54	160.9	0.2	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant S173D, D-alanine
alanine racemase AlrTt (MBAlr1)variant S173D	Thermoanaerobacter tengcongensis	L-alanine	34.69	157.5	0.22	pH 10, 65 °C	PMID 26218070	Open record: alanine racemase AlrTt (MBAlr1) variant S173D, L-alanine
AlrV (alanine racemase)	Vibrio cholerae	L-alanine	1.42	1.5	0.945		PMID 24419381	Open record: AlrV (alanine racemase), L-alanine
AlrV (alanine racemase)	Vibrio cholerae	L-serine	1.16	17	0.068		PMID 24419381	Open record: AlrV (alanine racemase), L-serine
cystathionine β-lyase TmCBL	Thermotoga maritima	D-glutamate	0.024	0.26	0.092	pH 8, 37 °C	PMID 28640457	Open record: cystathionine β-lyase TmCBL, D-glutamate
cystathionine β-lyase TmCBL	Thermotoga maritima	D-glutamate	1	1.4	0.69	pH 8, 70 °C	PMID 28640457	Open record: cystathionine β-lyase TmCBL, D-glutamate
cystathionine β-lyase TmCBL	Thermotoga maritima	L-alanine	0.022	4.2	0.0052	pH 8.8, 37 °C	PMID 28640457	Open record: cystathionine β-lyase TmCBL, L-alanine
cystathionine β-lyase TmCBL	Thermotoga maritima	L-alanine	0.0065	8.2	7.9 × 10⁻⁴	pH 8, 37 °C	PMID 28640457	Open record: cystathionine β-lyase TmCBL, L-alanine
cystathionine β-lyase TmCBL	Thermotoga maritima	L-alanine	0.0024	0.38	0.0063	pH 8, 70 °C	PMID 28640457	Open record: cystathionine β-lyase TmCBL, L-alanine
cystathionine β-lyase TmCBL	Thermotoga maritima	L-cystathionine	2.3	0.4	5.8	pH 8.8, 37 °C	PMID 28640457	Open record: cystathionine β-lyase TmCBL, L-cystathionine
cystathionine β-lyase TmCBL	Thermotoga maritima	L-cystathionine	3.3	0.7	4.7	pH 8, 37 °C	PMID 28640457	Open record: cystathionine β-lyase TmCBL, L-cystathionine
cystathionine β-lyase TmCBL	Thermotoga maritima	L-cystathionine	9.2	1.3	7.3	pH 8, 70 °C	PMID 28640457	Open record: cystathionine β-lyase TmCBL, L-cystathionine
cystathionine β-lyase wMelCBL	Wolbachia endosymbiont of Drosophila melanogaster	L-alanine	2.3	3.8	0.58	pH 8.8, 37 °C	PMID 28640457	Open record: cystathionine β-lyase wMelCBL, L-alanine