CatLogenzyme kinetics catalog

EC 5.3.99.3: prostaglandin-E synthase

IsomerasesOpen in Browse

CatLog read 11 records for EC 5.3.99.3 from 2 papers, for 1 organism. Names in these papers: microsomal prostaglandin E synthase-1 (mPGES-1).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 19 records for EC 5.3.99.3 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 5.3.99.3 in Browse.

Papers

PaperOrganismsRecords
Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed…Homo sapiens8
Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determinationHomo sapiens3

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
microsomal prostaglandin E synthase-1 (mPGES-1)Homo sapiensglutathione210.7130pH 7.4, 37 °CPMID 12672824Open
microsomal prostaglandin E synthase-1 (mPGES-1)Homo sapiensprostaglandin G2750.16470pH 7.4, 37 °CPMID 12672824Open
microsomal prostaglandin E synthase-1 (mPGES-1)Homo sapiensprostaglandin H2500.16310pH 7.4, 37 °CPMID 12672824Open
microsomal prostaglandin E synthase-1 (mPGES-1)Homo sapiensprostaglandin H2—0.2155—pH 7.2PMID 20369883Open
microsomal prostaglandin E synthase-1 (mPGES-1)variant N74AHomo sapiensprostaglandin H2—0.4643—pH 7.2PMID 20369883Open
microsomal prostaglandin E synthase-1 (mPGES-1)variant R122AHomo sapiensprostaglandin H2—0.372—pH 7.2PMID 20369883Open
microsomal prostaglandin E synthase-1 (mPGES-1)variant R70AHomo sapiensprostaglandin H2—0.296—pH 7.2PMID 20369883Open
microsomal prostaglandin E synthase-1 (mPGES-1)variant R70A/R122AHomo sapiensprostaglandin H2—0.4737—pH 7.2PMID 20369883Open
microsomal prostaglandin E synthase-1 (mPGES-1)variant T129VHomo sapiensprostaglandin H2—0.3842—pH 7.2PMID 20369883Open
microsomal prostaglandin E synthase-1 (mPGES-1)variant Y117AHomo sapiensprostaglandin H2—0.5345—pH 7.2PMID 20369883Open
microsomal prostaglandin E synthase-1 (mPGES-1)variant Y117SHomo sapiensprostaglandin H2—0.2832—pH 7.2PMID 20369883Open