EC 5.4.99.64: 2-hydroxyisobutanoyl-CoA mutase
IsomerasesOpen in Browse
CatLog read 25 records for EC 5.4.99.64 from 2 papers, for 1 organism. Names in these papers: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 5 records for EC 5.4.99.64 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 5.4.99.64 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Structural basis of the stereospecificity of bacterial B12-dependent 2-hydroxyisobutyryl-CoA mutase | Aquincola tertiaricarbonis | 18 |
| Bacterial acyl-CoA mutase specifically catalyzes coenzyme B12-dependent isomerization of 2-hydroxyisobutyryl-CoA and (S)-3-hydroxybutyryl-CoA | Aquincola tertiaricarbonis | 7 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) | Aquincola tertiaricarbonis | (R)-3-hydroxybutyryl-CoA | 0.0033 | 1.66 | 0.002 | pH 6.6, 30 °C | PMID 22433853 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB), (R)-3-hydroxybutyryl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) | Aquincola tertiaricarbonis | (S)-3-hydroxybutyryl-CoA | 0.2 | 0.128 | 1.5 | pH 6.6, 30 °C | PMID 22433853 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB), (S)-3-hydroxybutyryl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) | Aquincola tertiaricarbonis | 2-hydroxyisobutyryl-CoA | 0.05 | 0.104 | 0.48 | pH 6.6, 30 °C | PMID 22433853 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB), 2-hydroxyisobutyryl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) | Aquincola tertiaricarbonis | 3-methylbutanoyl-CoA | 0.0113 | 0.288 | 0.04 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB), 3-methylbutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) | Aquincola tertiaricarbonis | butyryl-CoA | 0.0033 | 3.34 | 0.001 | pH 6.6, 30 °C | PMID 22433853 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB), butyryl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) | Aquincola tertiaricarbonis | isobutyryl-CoA | 0.001 | 0.55 | 0.0017 | pH 6.6, 30 °C | PMID 22433853 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB), isobutyryl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) | Aquincola tertiaricarbonis | pivaloyl-CoA | 0.0163 | 0.374 | 0.043 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB), pivaloyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant D117A | Aquincola tertiaricarbonis | (R)-3-hydroxybutanoyl-CoA | 0.0273 | 0.0075 | 3.67 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant D117A, (R)-3-hydroxybutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant D117A | Aquincola tertiaricarbonis | (S)-3-hydroxybutanoyl-CoA | 0.0255 | 0.0146 | 1.75 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant D117A, (S)-3-hydroxybutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant D117A | Aquincola tertiaricarbonis | 2-hydroxyisobutanoyl-CoA | 0.0443 | 0.042 | 1.053 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant D117A, 2-hydroxyisobutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant D117V | Aquincola tertiaricarbonis | (R)-3-hydroxybutanoyl-CoA | 0.173 | 0.067 | 2.58 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant D117V, (R)-3-hydroxybutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant D117V | Aquincola tertiaricarbonis | (S)-3-hydroxybutanoyl-CoA | 0.0615 | 0.117 | 0.525 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant D117V, (S)-3-hydroxybutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant D117V | Aquincola tertiaricarbonis | 2-hydroxyisobutanoyl-CoA | 0.0447 | 0.0614 | 0.727 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant D117V, 2-hydroxyisobutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant D117V | Aquincola tertiaricarbonis | pivaloyl-CoA | 0.1395 | 0.0435 | 3.2 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant D117V, pivaloyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90A | Aquincola tertiaricarbonis | (R)-3-hydroxybutanoyl-CoA | 0.0035 | 0.298 | 0.012 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90A, (R)-3-hydroxybutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90A | Aquincola tertiaricarbonis | (S)-3-hydroxybutanoyl-CoA | 0.002 | 0.433 | 0.0047 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90A, (S)-3-hydroxybutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90A | Aquincola tertiaricarbonis | 2-hydroxyisobutanoyl-CoA | 0.0245 | 0.304 | 0.082 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90A, 2-hydroxyisobutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90A | Aquincola tertiaricarbonis | 3-methylbutanoyl-CoA | 0.009 | 0.147 | 0.062 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90A, 3-methylbutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90A | Aquincola tertiaricarbonis | pivaloyl-CoA | 0.0132 | 0.235 | 0.057 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90A, pivaloyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90L | Aquincola tertiaricarbonis | (S)-3-hydroxybutanoyl-CoA | 0.0035 | 0.663 | 0.0052 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90L, (S)-3-hydroxybutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90L | Aquincola tertiaricarbonis | 2-hydroxyisobutanoyl-CoA | 0.0067 | 0.517 | 0.013 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90L, 2-hydroxyisobutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90V | Aquincola tertiaricarbonis | (S)-3-hydroxybutyryl-CoA | 0.033 | — | — | pH 6.6, 30 °C | PMID 22433853 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90V, (S)-3-hydroxybutyryl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90V | Aquincola tertiaricarbonis | 2-hydroxyisobutyryl-CoA | 0.02 | — | — | pH 6.6, 30 °C | PMID 22433853 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90V, 2-hydroxyisobutyryl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90V | Aquincola tertiaricarbonis | 3-methylbutanoyl-CoA | 0.0093 | 0.329 | 0.028 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90V, 3-methylbutanoyl-CoA |
| 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB)variant I90V | Aquincola tertiaricarbonis | pivaloyl-CoA | 0.017 | 0.977 | 0.017 | pH 6.6, 30 °C | PMID 25720495 | Open record: 2-hydroxyisobutyryl-CoA mutase (HCM, HcmA/HcmB) variant I90V, pivaloyl-CoA |