EC 5.6.2.2: DNA topoisomerase (ATP-hydrolysing)
IsomerasesOpen in Browse
CatLog read 6 records for EC 5.6.2.2 from 1 paper, for 1 organism. Names in these papers: DNA gyrase.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 31 records for EC 5.6.2.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 5.6.2.2 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity | Mycobacterium tuberculosis | 6 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| DNA gyrase | Mycobacterium tuberculosis | adenosine 5'-triphosphate | 0.05 | 0.7 | 0.071 calc. | pH 7.5, 30 °C | PMID 30744994 | Open record: DNA gyrase, adenosine 5'-triphosphate |
| DNA gyrase | Mycobacterium tuberculosis | adenosine 5'-triphosphate | 0.06 | 0.8 | 0.075 calc. | pH 7.5, 30 °C | PMID 30744994 | Open record: DNA gyrase, adenosine 5'-triphosphate |
| DNA gyrasevariant D211K/E212K/E213K/E214K (GyrA 211DEEE214 to 211KKKK214; GyrBAKKKK) | Mycobacterium tuberculosis | adenosine 5'-triphosphate | 0.09 | 1 | 0.090 calc. | pH 7.5, 30 °C | PMID 30744994 | Open record: DNA gyrase variant D211K/E212K/E213K/E214K (GyrA 211DEEE214 to 211KKKK214; GyrBAKKKK), adenosine 5'-triphosphate |
| DNA gyrasevariant E221K/D225K/E228K/R236E/H244A (GyrB; GyrBAmC-loop) | Mycobacterium tuberculosis | adenosine 5'-triphosphate | 0.08 | 0.7 | 0.11 calc. | pH 7.5, 30 °C | PMID 30744994 | Open record: DNA gyrase variant E221K/D225K/E228K/R236E/H244A (GyrB; GyrBAmC-loop), adenosine 5'-triphosphate |
| DNA gyraseΔC-loop (GyrB residues 214-245 deleted; GyrBA57ΔC-loop) | Mycobacterium tuberculosis | adenosine 5'-triphosphate | 0.06 | 0.75 | 0.080 calc. | pH 7.5, 30 °C | PMID 30744994 | Open record: DNA gyrase ΔC-loop (GyrB residues 214-245 deleted; GyrBA57ΔC-loop), adenosine 5'-triphosphate |
| DNA gyraseΔC-loop (GyrB residues 214-245 deleted; GyrBAΔC-loop) | Mycobacterium tuberculosis | adenosine 5'-triphosphate | 0.11 | 0.3 | 0.37 calc. | pH 7.5, 30 °C | PMID 30744994 | Open record: DNA gyrase ΔC-loop (GyrB residues 214-245 deleted; GyrBAΔC-loop), adenosine 5'-triphosphate |