EC 6.1.2.1: D-alanine-(R)-lactate ligase
LigasesOpen in Browse
CatLog read 24 records for EC 6.1.2.1 from 2 papers, for 2 organisms. Names in these papers: VanA, VanB.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA | Enterococcus faecium | 16 |
| Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583 | Enterococcus faecalis | 8 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| VanA | Enterococcus faecium | D-2-hydroxybutyrate | — | 0.6 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-2-hydroxybutyrate |
| VanA | Enterococcus faecium | D-2-hydroxybutyrate | 1.8 | — | 3 | pH 8.6 | PMID 1931965 | Open record: VanA, D-2-hydroxybutyrate |
| VanA | Enterococcus faecium | D-2-hydroxycaproate | — | 11 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-2-hydroxycaproate |
| VanA | Enterococcus faecium | D-2-hydroxycaproate | 1.1 | — | 0.1 | pH 8.6 | PMID 1931965 | Open record: VanA, D-2-hydroxycaproate |
| VanA | Enterococcus faecium | D-2-hydroxyvalerate | — | 3.2 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-2-hydroxyvalerate |
| VanA | Enterococcus faecium | D-2-hydroxyvalerate | 2.6 | — | 0.81 | pH 8.6 | PMID 1931965 | Open record: VanA, D-2-hydroxyvalerate |
| VanA | Enterococcus faecium | D-alaninecosubstrate D-alanine | — | 3.8 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-alanine |
| VanA | Enterococcus faecium | D-alaninecosubstrate D-alanine | — | 38 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-alanine |
| VanA | Enterococcus faecium | D-alanine | 4.92 | — | 0.13 | pH 8.6 | PMID 1931965 | Open record: VanA, D-alanine |
| VanA | Enterococcus faecium | D-alaninecosubstrate D-lactate | — | 3.2 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-alanine |
| VanA | Enterococcus faecium | D-alaninecosubstrate D-2-hydroxybutyrate | — | 4.1 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-alanine |
| VanA | Enterococcus faecium | D-aminobutyrate | — | 0.77 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-aminobutyrate |
| VanA | Enterococcus faecium | D-lactate | — | 7.1 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-lactate |
| VanA | Enterococcus faecium | D-lactate | 1.57 | — | 0.22 | pH 8.6 | PMID 1931965 | Open record: VanA, D-lactate |
| VanA | Enterococcus faecium | D-phenyllactate | — | 60 | — | pH 8.6, 25 °C | PMID 1931965 | Open record: VanA, D-phenyllactate |
| VanA | Enterococcus faecium | D-phenyllactate | 1.25 | — | 0.02 | pH 8.6 | PMID 1931965 | Open record: VanA, D-phenyllactate |
| VanB | Enterococcus faecalis | (R)-2-hydroxybutanoate | 0.25 | 3 | 0.0836 | PMID 7957913 | Open record: VanB, (R)-2-hydroxybutanoate | |
| VanB | Enterococcus faecalis | (R)-2-hydroxypentanoate | 0.42 | 8.3 | 0.0502 | PMID 7957913 | Open record: VanB, (R)-2-hydroxypentanoate | |
| VanB | Enterococcus faecalis | (R)-lactate | 0.47 | 11.4 | 0.0414 | PMID 7957913 | Open record: VanB, (R)-lactate | |
| VanB | Enterococcus faecalis | adenosine 5'-triphosphate | — | 0.069 | — | PMID 7957913 | Open record: VanB, adenosine 5'-triphosphate | |
| VanB | Enterococcus faecalis | D-alanine | — | 1.2 | — | PMID 7957913 | Open record: VanB, D-alanine | |
| VanB | Enterococcus faecalis | D-alanine | — | 34 | — | PMID 7957913 | Open record: VanB, D-alanine | |
| VanB | Enterococcus faecalis | D-alanine | 4.1 | — | — | PMID 7957913 | Open record: VanB, D-alanine | |
| VanB | Enterococcus faecalis | D-alanine | — | — | 0.12 | PMID 7957913 | Open record: VanB, D-alanine |