EC 6.2.1.2: medium-chain acyl-CoA ligase
LigasesOpen in Browse
CatLog read 49 records for EC 6.2.1.2 from 4 papers, for 4 organisms. Names in these papers: medium-chain acyl-CoA synthetase (MacsMa), phenylacetyl-CoA ligase Phl (PCL), xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A), xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B) and 2 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 46 records for EC 6.2.1.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 6.2.1.2 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids | Homo sapiens | 14 |
| Characterization of an archaeal medium-chain acyl coenzyme A synthetase from Methanosarcina acetivorans | Methanosarcina acetivorans | 14 |
| Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea | Metallosphaera sedula | 12 |
| Cloning and characterization of a novel CoA-ligase gene from Penicillium chrysogenum | Penicillium chrysogenum | 9 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406) | Metallosphaera sedula | 3-hydroxypropionate | 2.6 | 0.81 | 3.2 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406), 3-hydroxypropionate |
| 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406) | Metallosphaera sedula | 4-hydroxybutyrate | 1.8 | 2 | 0.91 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406), 4-hydroxybutyrate |
| 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406) | Metallosphaera sedula | Acetate | 6.4 | 2.03 | 3.2 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406), Acetate |
| 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406) | Metallosphaera sedula | Butyrate | 8.4 | 0.32 | 26 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406), Butyrate |
| 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406) | Metallosphaera sedula | Propionate | 16.2 | 0.38 | 43 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406), Propionate |
| 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406) | Metallosphaera sedula | Valerate | 5.6 | 0.74 | 7.5 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (acetyl-CoA synthetase, Msed_0406), Valerate |
| 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394) | Metallosphaera sedula | 3-hydroxypropionate | 0.08 | 1.88 | 0.04 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394), 3-hydroxypropionate |
| 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394) | Metallosphaera sedula | 4-hydroxybutyrate | 0.24 | 1.54 | 0.16 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394), 4-hydroxybutyrate |
| 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394) | Metallosphaera sedula | Acetate | 0.14 | 0.68 | 0.2 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394), Acetate |
| 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394) | Metallosphaera sedula | Butyrate | 0.23 | 0.06 | 3.7 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394), Butyrate |
| 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394) | Metallosphaera sedula | Propionate | 0.21 | 0.54 | 0.39 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394), Propionate |
| 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394) | Metallosphaera sedula | Valerate | 0.22 | 0.12 | 2 | pH 7.9, 75 °C | PMID 23258541 | Open record: 4-hydroxybutyrate-CoA synthetase (AMP-dependent synthetase and ligase, Msed_0394), Valerate |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | 2-methylbutyratenon-varied substrates at saturating levels | 1.58 | 8.92 | 0.18 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), 2-methylbutyrate |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | 2-methylbutyrateacyl-adenylate formation and release in the absence of CoA | 0.21 | 2.7 | 0.075 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), 2-methylbutyrate |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | 2-methylpropionate | 0.54 | 6.3 | 0.085 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), 2-methylpropionate |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | 2-methylvalerate | 0.33 | 5.3 | 0.062 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), 2-methylvalerate |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | ATPnon-varied substrates at saturating levels; Table 2 | 1.94 | 4.21 | 0.46 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), ATP |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | ATPacyl-adenylate synthesis in the absence of CoA; Table 4 | 10.67 | 6.9 | 1.54 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), ATP |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | ATPacyl-adenylate synthesis in the absence of CoA; Table 4 | 4.98 | 6.72 | 0.74 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), ATP |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | ATPacyl-adenylate synthesis in the absence of CoA; Table 4 | 1.09 | 1.66 | 0.66 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), ATP |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | ATPacyl-adenylate synthesis in the absence of CoA; Table 4 | 0.16 | 0.38 | 0.43 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), ATP |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | ATPacyl-adenylate synthesis in the absence of CoA; Table 4 | 0.39 | 3.51 | 0.11 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), ATP |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | butyrate | 2.01 | 27.9 | 0.073 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), butyrate |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | coenzyme A | 2.15 | 4.09 | 0.53 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), coenzyme A |
| medium-chain acyl-CoA synthetase (MacsMa) | Methanosarcina acetivorans | propionate | 4.78 | 29.1 | 0.164 | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa), propionate |
| medium-chain acyl-CoA synthetase (MacsMa)variant K256L | Methanosarcina acetivorans | propionate | 0.22 | 101.1 | 0.0022 calc. | pH 7.5, 55 °C | PMID 20851904 | Open record: medium-chain acyl-CoA synthetase (MacsMa) variant K256L, propionate |
| phenylacetyl-CoA ligase Phl (PCL) | Penicillium chrysogenum | Cinnamic acid | 7.35 | 0.964 | 7.622 | pH 7.5, 30 °C | PMID 21625874 | Open record: phenylacetyl-CoA ligase Phl (PCL), Cinnamic acid |
| phenylacetyl-CoA ligase Phl (PCL) | Penicillium chrysogenum | Coumaric acid | 1.73 | 0.603 | 2.868 | pH 7.5, 30 °C | PMID 21625874 | Open record: phenylacetyl-CoA ligase Phl (PCL), Coumaric acid |
| phenylacetyl-CoA ligase Phl (PCL) | Penicillium chrysogenum | decanoic acid | 7.7 | 0.104 | 73.86 | pH 7.5, 30 °C | PMID 21625874 | Open record: phenylacetyl-CoA ligase Phl (PCL), decanoic acid |
| phenylacetyl-CoA ligase Phl (PCL) | Penicillium chrysogenum | hexadecanoic acid | 6.82 | 0.548 | 12.44 | pH 7.5, 30 °C | PMID 21625874 | Open record: phenylacetyl-CoA ligase Phl (PCL), hexadecanoic acid |
| phenylacetyl-CoA ligase Phl (PCL) | Penicillium chrysogenum | hexanoic acid | 19.5 | 0.813 | 23.95 | pH 7.5, 30 °C | PMID 21625874 | Open record: phenylacetyl-CoA ligase Phl (PCL), hexanoic acid |
| phenylacetyl-CoA ligase Phl (PCL) | Penicillium chrysogenum | octadecanoic acid | 0.98 | 0.128 | 7.669 | pH 7.5, 30 °C | PMID 21625874 | Open record: phenylacetyl-CoA ligase Phl (PCL), octadecanoic acid |
| phenylacetyl-CoA ligase Phl (PCL) | Penicillium chrysogenum | octanoic acid | 12.04 | 0.199 | 60.44 | pH 7.5, 30 °C | PMID 21625874 | Open record: phenylacetyl-CoA ligase Phl (PCL), octanoic acid |
| phenylacetyl-CoA ligase Phl (PCL) | Penicillium chrysogenum | phenoxyacetic acid | 4.27 | 0.952 | 4.487 | pH 7.5, 30 °C | PMID 21625874 | Open record: phenylacetyl-CoA ligase Phl (PCL), phenoxyacetic acid |
| phenylacetyl-CoA ligase Phl (PCL) | Penicillium chrysogenum | phenylacetic acid | 1.34 | 3.335 | 0.402 | pH 7.5, 30 °C | PMID 21625874 | Open record: phenylacetyl-CoA ligase Phl (PCL), phenylacetic acid |
| xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A) | Homo sapiens | benzoate | — | 0.013 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A), benzoate |
| xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A) | Homo sapiens | butyrate | — | 0.8 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A), butyrate |
| xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A) | Homo sapiens | decanoate | — | 0.11 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A), decanoate |
| xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A) | Homo sapiens | hexanoate | — | 0.074 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A), hexanoate |
| xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A) | Homo sapiens | laurate | — | 0.06 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A), laurate |
| xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A) | Homo sapiens | phenylacetate | — | 0.16 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A), phenylacetate |
| xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A) | Homo sapiens | salicylate | — | 0.0074 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form A (HXM-A), salicylate |
| xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B) | Homo sapiens | benzoate | — | 0.021 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B), benzoate |
| xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B) | Homo sapiens | butyrate | — | 0.57 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B), butyrate |
| xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B) | Homo sapiens | decanoate | — | 0.02 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B), decanoate |
| xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B) | Homo sapiens | hexanoate | — | 0.034 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B), hexanoate |
| xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B) | Homo sapiens | laurate | — | 0.024 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B), laurate |
| xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B) | Homo sapiens | phenylacetate | — | 0.143 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B), phenylacetate |
| xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B) | Homo sapiens | salicylate | — | 0.025 | — | pH 8, 30 °C | PMID 10434065 | Open record: xenobiotic/medium-chain fatty acid:CoA ligase form B (HXM-B), salicylate |