EC 6.3.2.12: dihydrofolate synthase
LigasesOpen in Browse
CatLog read 4 records for EC 6.3.2.12 from 1 paper, for 1 organism. Names in these papers: dihydrofolate synthase–folylpolyglutamate synthase (DHFS activity).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 20 records for EC 6.3.2.12 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 6.3.2.12 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition | Plasmodium falciparum | 4 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| dihydrofolate synthase–folylpolyglutamate synthase (DHFS activity) | Plasmodium falciparum | 7,8-dihydropteroatenon-linear Michaelis-Menten fit | — | 8.8 × 10⁻⁴ | — | pH 10, 37 °C | PMID 20350571 | Open record: dihydrofolate synthase–folylpolyglutamate synthase (DHFS activity), 7,8-dihydropteroate |
| dihydrofolate synthase–folylpolyglutamate synthase (DHFS activity) | Plasmodium falciparum | 7,8-dihydropteroate | 0.04 | — | — | pH 10, 37 °C | PMID 20350571 | Open record: dihydrofolate synthase–folylpolyglutamate synthase (DHFS activity), 7,8-dihydropteroate |
| dihydrofolate synthase–folylpolyglutamate synthase (DHFS activity) | Plasmodium falciparum | ATP | — | 0.0228 | — | pH 10, 37 °C | PMID 20350571 | Open record: dihydrofolate synthase–folylpolyglutamate synthase (DHFS activity), ATP |
| dihydrofolate synthase–folylpolyglutamate synthase (DHFS activity) | Plasmodium falciparum | L-glutamate | — | 0.00597 | — | pH 10, 37 °C | PMID 20350571 | Open record: dihydrofolate synthase–folylpolyglutamate synthase (DHFS activity), L-glutamate |