EC 6.5.1.1: DNA ligase (ATP)

LigasesOpen in Browse

CatLog read 16 records for EC 6.5.1.1 from 3 papers, for 3 organisms. Names in these papers: T4 DNA ligase, DNA ligase 1 (LIG1), 3-hydroxypropionyl-CoA synthetase.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 48 records for EC 6.5.1.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 6.5.1.1 in Browse.

Papers

Papers with records for EC 6.5.1.1
Paper	Organisms	Records
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate)…	bacteriophage T4	7
Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion	Homo sapiens	6
3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation	Sulfolobus tokodaii	3

Records

Records for EC 6.5.1.1 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
3-hydroxypropionyl-CoA synthetasevariant I518L	Sulfolobus tokodaii	3-Hydroxypropionate	8	—	—	pH 8.4, 65 °C	PMID 18165310	Open record: 3-hydroxypropionyl-CoA synthetase variant I518L, 3-Hydroxypropionate
3-hydroxypropionyl-CoA synthetasevariant I518L	Sulfolobus tokodaii	3-Hydroxypropionate	—	0.19	—	pH 7.2, 45 °C	PMID 18165310	Open record: 3-hydroxypropionyl-CoA synthetase variant I518L, 3-Hydroxypropionate
3-hydroxypropionyl-CoA synthetasevariant I518L	Sulfolobus tokodaii	ATP	—	0.11	—	pH 7.2, 45 °C	PMID 18165310	Open record: 3-hydroxypropionyl-CoA synthetase variant I518L, ATP
DNA ligase 1 (LIG1)	Homo sapiens	8-oxoG:A nicked DNA (28mer)	0.08	3.17 × 10⁻⁵	2.4 × 10³	pH 7.5, 37 °C	PMID 41770933	Open record: DNA ligase 1 (LIG1), 8-oxoG:A nicked DNA (28mer)
DNA ligase 1 (LIG1)	Homo sapiens	C:G nicked DNA (28mer)	0.52	4.16 × 10⁻⁵	1.25 × 10⁴	pH 7.5, 37 °C	PMID 41770933	Open record: DNA ligase 1 (LIG1), C:G nicked DNA (28mer)
DNA ligase 1 (LIG1)	Homo sapiens	C:G nicked DNA (28mer, undamaged canonical nick)	0.52	—	—	pH 7.5, 37 °C	PMID 41770933	Open record: DNA ligase 1 (LIG1), C:G nicked DNA (28mer, undamaged canonical nick)
DNA ligase 1 (LIG1)variant K845N	Homo sapiens	8-oxoG:A nicked DNA (28mer)	0.003	7.33 × 10⁻⁵	40	pH 7.5, 37 °C	PMID 41770933	Open record: DNA ligase 1 (LIG1) variant K845N, 8-oxoG:A nicked DNA (28mer)
DNA ligase 1 (LIG1)variant K845N	Homo sapiens	C:G nicked DNA (28mer)	0.2	8.07 × 10⁻⁵	2.5 × 10³	pH 7.5, 37 °C	PMID 41770933	Open record: DNA ligase 1 (LIG1) variant K845N, C:G nicked DNA (28mer)
DNA ligase 1 (LIG1)variant K845N	Homo sapiens	C:G nicked DNA (28mer, undamaged canonical nick)	0.2	—	—	pH 7.5, 37 °C	PMID 41770933	Open record: DNA ligase 1 (LIG1) variant K845N, C:G nicked DNA (28mer, undamaged canonical nick)
T4 DNA ligase	bacteriophage T4	dimethylallyl diphosphate	0.0492	4	0.0123	pH 7.2, 30 °C	PMID 19414000	Open record: T4 DNA ligase, dimethylallyl diphosphate
T4 DNA ligase	bacteriophage T4	farnesyl diphosphate	0.0028	0.05	0.056	pH 7.2, 30 °C	PMID 19414000	Open record: T4 DNA ligase, farnesyl diphosphate
T4 DNA ligase	bacteriophage T4	farnesyl triphosphate	0.0349	0.15	0.232	pH 7.2, 30 °C	PMID 19414000	Open record: T4 DNA ligase, farnesyl triphosphate
T4 DNA ligase	bacteriophage T4	geranyl diphosphate	8 × 10⁻⁴	0.21	0.0038	pH 7.2, 30 °C	PMID 19414000	Open record: T4 DNA ligase, geranyl diphosphate
T4 DNA ligase	bacteriophage T4	geranyl triphosphate	0.0319	0.31	0.103	pH 7.2, 30 °C	PMID 19414000	Open record: T4 DNA ligase, geranyl triphosphate
T4 DNA ligase	bacteriophage T4	isopentenyl diphosphate	0.0316	2.3	0.0138	pH 7.2, 30 °C	PMID 19414000	Open record: T4 DNA ligase, isopentenyl diphosphate
T4 DNA ligase	bacteriophage T4	isopentenyl triphosphate	0.0729	0.63	0.116	pH 7.2, 30 °C	PMID 19414000	Open record: T4 DNA ligase, isopentenyl triphosphate