Values CatLog read from this paper
Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion
PMID 41770933doi:10.1073/pnas.2518854123Open in Browse
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CatLog read 6 records (14 values) from this paper: DNA ligase 1 (LIG1) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| DNA ligase 1 (LIG1) | Homo sapiens | 8-oxoG:A nicked DNA (28mer) | 0.08 | 3.17 × 10⁻⁵ | 2.4 × 10³ | pH 7.5, 37 °C | Open record: DNA ligase 1 (LIG1), 8-oxoG:A nicked DNA (28mer) |
| DNA ligase 1 (LIG1) | Homo sapiens | C:G nicked DNA (28mer) | 0.52 | 4.16 × 10⁻⁵ | 1.25 × 10⁴ | pH 7.5, 37 °C | Open record: DNA ligase 1 (LIG1), C:G nicked DNA (28mer) |
| DNA ligase 1 (LIG1) | Homo sapiens | C:G nicked DNA (28mer, undamaged canonical nick) | 0.52 | — | — | pH 7.5, 37 °C | Open record: DNA ligase 1 (LIG1), C:G nicked DNA (28mer, undamaged canonical nick) |
| DNA ligase 1 (LIG1)variant K845N | Homo sapiens | 8-oxoG:A nicked DNA (28mer) | 0.003 | 7.33 × 10⁻⁵ | 40 | pH 7.5, 37 °C | Open record: DNA ligase 1 (LIG1) variant K845N, 8-oxoG:A nicked DNA (28mer) |
| DNA ligase 1 (LIG1)variant K845N | Homo sapiens | C:G nicked DNA (28mer) | 0.2 | 8.07 × 10⁻⁵ | 2.5 × 10³ | pH 7.5, 37 °C | Open record: DNA ligase 1 (LIG1) variant K845N, C:G nicked DNA (28mer) |
| DNA ligase 1 (LIG1)variant K845N | Homo sapiens | C:G nicked DNA (28mer, undamaged canonical nick) | 0.2 | — | — | pH 7.5, 37 °C | Open record: DNA ligase 1 (LIG1) variant K845N, C:G nicked DNA (28mer, undamaged canonical nick) |