Values CatLog read from this paper
Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and…
PMID 10998348doi:10.1042/0264-6021:3510067Open in Browse
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CatLog read 26 records (77 values) from this paper: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD), AKR1C4 (type 1 3α-HSD, chlordecone reductase) and 1 more from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | 17β-hydroxy-5α-androstan-3-one | 0.011 | 0.0806 | 0.13 | pH 7, 37 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), 17β-hydroxy-5α-androstan-3-one |
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | 17β-hydroxy-5α-androstan-3-one | 4.3 × 10⁻⁴ | 0.0317 | 0.013 | pH 7, 25 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), 17β-hydroxy-5α-androstan-3-one |
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | 20α-hydroxy-5β-pregnan-3-one | 0.0538 | 0.0194 | 2.78 | pH 7, 25 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), 20α-hydroxy-5β-pregnan-3-one |
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | 20α-hydroxyprogesterone | 0.02 | 0.0147 | 1.37 | pH 7, 25 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), 20α-hydroxyprogesterone |
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | 3α-hydroxy-5α-androstan-17-onespectrophotometric assay (NADPH formation at 340 nm) | 0.001 | 0.0417 | 0.023 | pH 7, 25 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), 3α-hydroxy-5α-androstan-17-one |
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | 3α-hydroxy-5α-androstan-17-onespectrophotometric assay (NADPH absorbance change at 340 nm) | 0.003 | 0.021 | 0.15 | pH 7, 25 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), 3α-hydroxy-5α-androstan-17-one |
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | 3β-hydroxy-5β-pregnan-20-one | 0.0183 | 0.0162 | 1.13 | pH 7, 25 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), 3β-hydroxy-5β-pregnan-20-one |
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | 5α-androstane-3,17-dione | 0.0078 | 0.00677 | 1.2 | pH 7, 25 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), 5α-androstane-3,17-dione |
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | progesterone | 0.0048 | 0.00265 | 1.82 | pH 7, 25 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), progesterone |
| AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1) | Homo sapiens | testosterone | 7.3 × 10⁻⁴ | 0.0398 | 0.018 | pH 7, 37 °C | Open record: AKR1C1 (20α(3α)-HSD, dihydrodiol dehydrogenase 1), testosterone |
| AKR1C2 (type 3 3α-HSD, bile-acid binding protein) | Homo sapiens | 17β-hydroxy-5α-androstan-3-one | 0.0038 | 0.026 | 0.15 | pH 7, 37 °C | Open record: AKR1C2 (type 3 3α-HSD, bile-acid binding protein), 17β-hydroxy-5α-androstan-3-one |
| AKR1C2 (type 3 3α-HSD, bile-acid binding protein) | Homo sapiens | 3α-hydroxy-5α-androstan-17-one | 0.007 | 0.00973 | 0.72 | pH 7, 25 °C | Open record: AKR1C2 (type 3 3α-HSD, bile-acid binding protein), 3α-hydroxy-5α-androstan-17-one |
| AKR1C2 (type 3 3α-HSD, bile-acid binding protein) | Homo sapiens | 5α-androstane-3,17-dione | 0.0232 | 0.00626 | 3.7 | pH 7, 25 °C | Open record: AKR1C2 (type 3 3α-HSD, bile-acid binding protein), 5α-androstane-3,17-dione |
| AKR1C2 (type 3 3α-HSD, bile-acid binding protein) | Homo sapiens | 5α-androstane-3α,17β-diol | 0.004 | 0.022 | 0.18 | pH 7, 25 °C | Open record: AKR1C2 (type 3 3α-HSD, bile-acid binding protein), 5α-androstane-3α,17β-diol |
| AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD) | Homo sapiens | 17β-hydroxy-5α-androstan-3-one | 0.0042 | — | 0.1 | pH 7, 37 °C | Open record: AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD), 17β-hydroxy-5α-androstan-3-one |
| AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD) | Homo sapiens | 17β-hydroxy-5α-androstan-3-onespectrophotometric assay (NADPH absorbance change at 340 nm) | 0.0043 | 0.0198 | 0.22 | pH 7, 25 °C | Open record: AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD), 17β-hydroxy-5α-androstan-3-one |
| AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD) | Homo sapiens | 17β-hydroxy-5α-androstan-3-onespectrophotometric assay (NADPH formation at 340 nm) | 7.7 × 10⁻⁴ | 0.0119 | 0.063 | pH 7, 25 °C | Open record: AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD), 17β-hydroxy-5α-androstan-3-one |
| AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD) | Homo sapiens | 3α-hydroxy-5α-androstan-17-one | 0.0062 | 0.00896 | 0.7 | pH 7, 25 °C | Open record: AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD), 3α-hydroxy-5α-androstan-17-one |
| AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD) | Homo sapiens | 5α-androstane-3,17-dione | 0.0047 | 0.005 | 0.93 | pH 7, 25 °C | Open record: AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD), 5α-androstane-3,17-dione |
| AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD) | Homo sapiens | 5α-androstane-3α,17β-diol | 0.0025 | 0.0272 | 0.1 | pH 7, 25 °C | Open record: AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD), 5α-androstane-3α,17β-diol |
| AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD) | Homo sapiens | testosterone | 8.2 × 10⁻⁴ | 0.0243 | 0.033 | pH 7, 37 °C | Open record: AKR1C3 (type 2 3α(17β)-HSD, type 5 17β-HSD), testosterone |
| AKR1C4 (type 1 3α-HSD, chlordecone reductase) | Homo sapiens | 17β-hydroxy-5α-androstan-3-one | 0.032 | 0.0083 | 3.85 | pH 7, 37 °C | Open record: AKR1C4 (type 1 3α-HSD, chlordecone reductase), 17β-hydroxy-5α-androstan-3-one |
| AKR1C4 (type 1 3α-HSD, chlordecone reductase) | Homo sapiens | 17β-hydroxy-5α-androstan-3-one | 0.0332 | 0.0034 | 9.77 | pH 7, 25 °C | Open record: AKR1C4 (type 1 3α-HSD, chlordecone reductase), 17β-hydroxy-5α-androstan-3-one |
| AKR1C4 (type 1 3α-HSD, chlordecone reductase) | Homo sapiens | 3α-hydroxy-5α-androstan-17-one | 0.0232 | 0.00504 | 4.6 | pH 7, 25 °C | Open record: AKR1C4 (type 1 3α-HSD, chlordecone reductase), 3α-hydroxy-5α-androstan-17-one |
| AKR1C4 (type 1 3α-HSD, chlordecone reductase) | Homo sapiens | 5α-androstane-3,17-dione | 0.0298 | 0.00144 | 20.72 | pH 7, 25 °C | Open record: AKR1C4 (type 1 3α-HSD, chlordecone reductase), 5α-androstane-3,17-dione |
| AKR1C4 (type 1 3α-HSD, chlordecone reductase) | Homo sapiens | 5α-androstane-3α,17β-diol | 0.035 | 0.0105 | 3.3 | pH 7, 25 °C | Open record: AKR1C4 (type 1 3α-HSD, chlordecone reductase), 5α-androstane-3α,17β-diol |