Values CatLog read from this paper
Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity
PMID 12192082doi:10.1110/ps.2460102Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 12 records (36 values) from this paper: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) from Herpes Simplex Virus type 1.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) | Herpes Simplex Virus type 1 | acyclovir | 0.015 | 0.417 | 0.036 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK), acyclovir |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) | Herpes Simplex Virus type 1 | ganciclovir | 0.1 | 0.0476 | 2.1 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK), ganciclovir |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) | Herpes Simplex Virus type 1 | thymidine | 0.46 | 3.8 × 10⁻⁴ | 1.2 × 10³ | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK), thymidine |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK)variant SR11 | Herpes Simplex Virus type 1 | acyclovir | 4.7 × 10⁻⁴ | 0.0056 | 0.083 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) variant SR11, acyclovir |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK)variant SR11 | Herpes Simplex Virus type 1 | ganciclovir | 0.0056 | 0.00641 | 0.87 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) variant SR11, ganciclovir |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK)variant SR11 | Herpes Simplex Virus type 1 | thymidine | 0.007 | 9.5 × 10⁻⁴ | 7.3 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) variant SR11, thymidine |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK)variant SR26 | Herpes Simplex Virus type 1 | acyclovir | 2.8 × 10⁻⁴ | 0.00337 | 0.083 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) variant SR26, acyclovir |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK)variant SR26 | Herpes Simplex Virus type 1 | ganciclovir | 0.0089 | 0.01755 | 0.051 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) variant SR26, ganciclovir |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK)variant SR26 | Herpes Simplex Virus type 1 | thymidine | 0.0062 | 0.0013 | 4.8 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) variant SR26, thymidine |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK)variant SR39 | Herpes Simplex Virus type 1 | acyclovir | 4.3 × 10⁻⁴ | 0.00979 | 0.044 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) variant SR39, acyclovir |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK)variant SR39 | Herpes Simplex Virus type 1 | ganciclovir | 0.0035 | 0.00333 | 1.1 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) variant SR39, ganciclovir |
| Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK)variant SR39 | Herpes Simplex Virus type 1 | thymidine | 0.017 | 0.00264 | 6.3 | 37 °C | Open record: Herpes Simplex Virus type 1 thymidine kinase (HSV-1 TK) variant SR39, thymidine |