CatLogenzyme kinetics catalog

Values CatLog read from this paper

Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds

PMID 12614151doi:10.1021/bi027302tOpen in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 10 records (14 values) from this paper: thymidylate kinase (TMPK) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 4 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.

EC 2.7.4.9

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
thymidylate kinase (TMPK)Homo sapiens2',3'-didehydro-2',3'-dideoxythymidine monophosphate0.090.0127.5 calc.pH 7.5, 25 °COpen
thymidylate kinase (TMPK)Homo sapiens3'-amino-3'-deoxythymidine monophosphate0.14——pH 7.5, 25 °COpen
thymidylate kinase (TMPK)Homo sapiens3'-azido-3'-deoxythymidine monophosphate0.010.0120.83 calc.pH 7.5, 25 °COpen
thymidylate kinase (TMPK)Homo sapiens3'-fluoro-3'-deoxythymidine monophosphate0.030.0083.8 calc.pH 7.5, 25 °COpen
thymidylate kinase (TMPK)Homo sapiensadenosine 5'-triphosphatecosubstrate TMP—0.005—pH 7.5, 25 °COpen
thymidylate kinase (TMPK)Homo sapiensadenosine 5'-triphosphatecosubstrate AZTMP—0.069—pH 7.5, 25 °COpen
thymidylate kinase (TMPK)Homo sapiensadenosine 5'-triphosphatecosubstrate d4TMP—0.033—pH 7.5, 25 °COpen
thymidylate kinase (TMPK)Homo sapiensadenosine 5'-triphosphatecosubstrate FLTMP—0.027—pH 7.5, 25 °COpen
thymidylate kinase (TMPK)Homo sapiensdideoxythymidine monophosphate0.03——pH 7.5, 25 °COpen
thymidylate kinase (TMPK)Homo sapiensthymidine 5'-monophosphate0.70.005140 calc.pH 7.5, 25 °COpen