EC 2.7.4.9: dTMP kinase
TransferasesOpen in Browse
CatLog read 38 records for EC 2.7.4.9 from 5 papers, for 2 organisms. Names in these papers: thymidylate kinase (TMP kinase), thymidylate kinase (TMPK), thymidylate kinase (TMPKmt), dTMP kinase (thymidylate kinase, hTMPK).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 48 records for EC 2.7.4.9 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.4.9 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates | Homo sapiens | 14 |
| Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds | Homo sapiens | 10 |
| Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes | Mycobacterium tuberculosis | 9 |
| Enantioselectivity of human AMP, dTMP and UMP-CMP kinases | Homo sapiens | 4 |
| Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metabolite | Homo sapiens | 1 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| dTMP kinase (thymidylate kinase, hTMPK) | Homo sapiens | 2'-deoxyuridine 5'-monophosphate | 4.8 | 0.17 | 28 | pH 7.4, 37 °C | PMID 17626051 | Open record: dTMP kinase (thymidylate kinase, hTMPK), 2'-deoxyuridine 5'-monophosphate |
| dTMP kinase (thymidylate kinase, hTMPK) | Homo sapiens | beta-L-2'-deoxyuridine 5'-monophosphate | 0.13 | 2.3 | 0.06 | pH 7.4, 37 °C | PMID 17626051 | Open record: dTMP kinase (thymidylate kinase, hTMPK), beta-L-2'-deoxyuridine 5'-monophosphate |
| dTMP kinase (thymidylate kinase, hTMPK) | Homo sapiens | beta-L-thymidine 5'-monophosphate | 0.34 | 0.38 | 0.9 | pH 7.4, 37 °C | PMID 17626051 | Open record: dTMP kinase (thymidylate kinase, hTMPK), beta-L-thymidine 5'-monophosphate |
| dTMP kinase (thymidylate kinase, hTMPK) | Homo sapiens | thymidine 5'-monophosphate | 3 | 0.02 | 150 | pH 7.4, 37 °C | PMID 17626051 | Open record: dTMP kinase (thymidylate kinase, hTMPK), thymidine 5'-monophosphate |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-3-dihydroxyphosphonyl-prop-2-enyl]-thymine | 0.6 | 1 | 0.6 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-3-dihydroxyphosphonyl-prop-2-enyl]-thymine |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-bromouracil | 0.9 | 0.02 | 45 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-bromouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-chlorouracil | 0.5 | 0.13 | 4.1 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-chlorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-fluorouracil | 0.73 | 1 | 0.73 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-fluorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-thymine | 0.84 | 0.024 | 35 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-thymine |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-uracil | 0.48 | 1.7 | 0.28 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-uracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-bromouracil | 0.058 | 0.16 | 0.36 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-bromouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-chlorouracil | 0.1 | 0.15 | 0.66 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-chlorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-fluorouracil | 0.09 | 1.9 | 0.047 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-fluorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-thymine | 0.32 | 0.1 | 3.2 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-thymine |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-uracil | 0.074 | 2.5 | 0.03 | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-uracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-5-bromouracil | 0.2 | 0.4 | 0.50 calc. | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-5-bromouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-5-fluorouracil | 0.037 | 0.3 | 0.12 calc. | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-5-fluorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-uracil | 0.12 | 0.55 | 0.22 calc. | pH 7.4, 37 °C | PMID 21128666 | Open record: thymidylate kinase (TMP kinase), N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-uracil |
| thymidylate kinase (TMPK) | Homo sapiens | 2',3'-didehydro-2',3'-dideoxythymidine monophosphate | 0.09 | 0.012 | 7.5 calc. | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), 2',3'-didehydro-2',3'-dideoxythymidine monophosphate |
| thymidylate kinase (TMPK) | Homo sapiens | 3'-amino-3'-deoxythymidine monophosphate | 0.14 | — | — | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), 3'-amino-3'-deoxythymidine monophosphate |
| thymidylate kinase (TMPK) | Homo sapiens | 3'-azido-3'-deoxythymidine monophosphate | 0.01 | 0.012 | 0.83 calc. | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), 3'-azido-3'-deoxythymidine monophosphate |
| thymidylate kinase (TMPK) | Homo sapiens | 3'-fluoro-3'-deoxythymidine monophosphate | 0.03 | 0.008 | 3.8 calc. | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), 3'-fluoro-3'-deoxythymidine monophosphate |
| thymidylate kinase (TMPK) | Homo sapiens | adenosine 5'-triphosphatecosubstrate TMP | — | 0.005 | — | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), adenosine 5'-triphosphate |
| thymidylate kinase (TMPK) | Homo sapiens | adenosine 5'-triphosphatecosubstrate AZTMP | — | 0.069 | — | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), adenosine 5'-triphosphate |
| thymidylate kinase (TMPK) | Homo sapiens | adenosine 5'-triphosphatecosubstrate d4TMP | — | 0.033 | — | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), adenosine 5'-triphosphate |
| thymidylate kinase (TMPK) | Homo sapiens | adenosine 5'-triphosphatecosubstrate FLTMP | — | 0.027 | — | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), adenosine 5'-triphosphate |
| thymidylate kinase (TMPK) | Homo sapiens | dideoxythymidine monophosphate | 0.03 | — | — | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), dideoxythymidine monophosphate |
| thymidylate kinase (TMPK) | Homo sapiens | thymidine 5'-monophosphate | 0.7 | 0.005 | 140 calc. | pH 7.5, 25 °C | PMID 12614151 | Open record: thymidylate kinase (TMPK), thymidine 5'-monophosphate |
| thymidylate kinase (TMPK) | Homo sapiens | thymidine monophosphate | 0.0043 | 0.0329 | 0.13 | pH 7.5 | PMID 42363837 | Open record: thymidylate kinase (TMPK), thymidine monophosphate |
| thymidylate kinase (TMPKmt) | Mycobacterium tuberculosis | 2'-deoxyuridine 5'-monophosphate | — | 2.1 | — | pH 7.4, 30 °C | PMID 11369858 | Open record: thymidylate kinase (TMPKmt), 2'-deoxyuridine 5'-monophosphate |
| thymidylate kinase (TMPKmt) | Mycobacterium tuberculosis | 3'-fluoro-3'-deoxythymidine 5'-monophosphate | — | 0.03 | — | pH 7.4, 30 °C | PMID 11369858 | Open record: thymidylate kinase (TMPKmt), 3'-fluoro-3'-deoxythymidine 5'-monophosphate |
| thymidylate kinase (TMPKmt) | Mycobacterium tuberculosis | 5-bromo-2'-deoxyuridine 5'-monophosphate | — | 0.03 | — | pH 7.4, 30 °C | PMID 11369858 | Open record: thymidylate kinase (TMPKmt), 5-bromo-2'-deoxyuridine 5'-monophosphate |
| thymidylate kinase (TMPKmt) | Mycobacterium tuberculosis | 5-fluoro-2'-deoxyuridine 5'-monophosphate | — | 0.42 | — | pH 7.4, 30 °C | PMID 11369858 | Open record: thymidylate kinase (TMPKmt), 5-fluoro-2'-deoxyuridine 5'-monophosphate |
| thymidylate kinase (TMPKmt) | Mycobacterium tuberculosis | 5-iodo-2'-deoxyuridine 5'-monophosphate | — | 0.14 | — | pH 7.4, 30 °C | PMID 11369858 | Open record: thymidylate kinase (TMPKmt), 5-iodo-2'-deoxyuridine 5'-monophosphate |
| thymidylate kinase (TMPKmt) | Mycobacterium tuberculosis | adenosine 5'-triphosphate | — | 0.1 | — | pH 7.4, 30 °C | PMID 11369858 | Open record: thymidylate kinase (TMPKmt), adenosine 5'-triphosphate |
| thymidylate kinase (TMPKmt) | Mycobacterium tuberculosis | dehydro-TMP | — | 0.14 | — | pH 7.4, 30 °C | PMID 11369858 | Open record: thymidylate kinase (TMPKmt), dehydro-TMP |
| thymidylate kinase (TMPKmt) | Mycobacterium tuberculosis | thymidine 5'-monophosphateATP fixed at 0.2; 0.3 | 4.5 | 0.0045 | 1.0 × 10³ calc. | pH 7.4, 30 °C | PMID 11369858 | Open record: thymidylate kinase (TMPKmt), thymidine 5'-monophosphate |
| thymidylate kinase (TMPKmt) | Mycobacterium tuberculosis | thymidine 5'-monophosphateATP fixed at 0.5 mM; NMP varied 0.05-3.6 mM | — | 0.04 | — | pH 7.4, 30 °C | PMID 11369858 | Open record: thymidylate kinase (TMPKmt), thymidine 5'-monophosphate |