Values CatLog read from this paper
Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metabolite
PMID 42363837doi:10.1128/aac.00055-26Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 26 records (78 values) from this paper: adenosine kinase (ADK), adenylate kinase 2 (AK2), NM23H1 (nucleoside diphosphate kinase A) and 16 more from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
EC 2.7.1.20, EC 2.7.1.21, EC 2.7.1.40, EC 2.7.1.48, EC 2.7.1.74, EC 2.7.4.3, EC 2.7.4.4, EC 2.7.4.6, EC 2.7.4.9
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| adenosine kinase (ADK) | Homo sapiens | adenosine | 0.237 | 7.2 × 10⁻⁴ | 330 | pH 7.5 | Open record: adenosine kinase (ADK), adenosine |
| adenosine kinase (ADK) | Homo sapiens | GS-441524 | 5.5 × 10⁻⁵ | 0.193 | 2.85 × 10⁻⁴ | pH 7.5 | Open record: adenosine kinase (ADK), GS-441524 |
| adenylate kinase 1 (AK1) | Homo sapiens | adenosine monophosphate | 24.95 | 0.756 | 33 | pH 7.5, 37 °C | Open record: adenylate kinase 1 (AK1), adenosine monophosphate |
| adenylate kinase 2 (AK2) | Homo sapiens | adenosine monophosphate | 11.68 | 0.197 | 59.3 | pH 7.5, 37 °C | Open record: adenylate kinase 2 (AK2), adenosine monophosphate |
| adenylate kinase 2 (AK2) | Homo sapiens | GS-441524 5'-monophosphate | 4.2 | 0.84 | 5 | pH 7.5, 37 °C | Open record: adenylate kinase 2 (AK2), GS-441524 5'-monophosphate |
| creatine kinase MB (CKMB) | Homo sapiens | adenosine diphosphate | 5.25 | 0.14 | 37.7 | pH 7 | Open record: creatine kinase MB (CKMB), adenosine diphosphate |
| creatine kinase MM (CKMM) | Homo sapiens | adenosine diphosphate | 2.27 | 0.257 | 8.8 | pH 7 | Open record: creatine kinase MM (CKMM), adenosine diphosphate |
| deoxycytidine kinase (dCK) | Homo sapiens | 2'-deoxycytidine | 6.7 × 10⁻⁴ | 2.18 × 10⁻⁴ | 3.2 | pH 7.5 | Open record: deoxycytidine kinase (dCK), 2'-deoxycytidine |
| deoxyguanosine kinase (dGK) | Homo sapiens | 2'-deoxyguanosine | 0.004 | 8.3 × 10⁻⁴ | 4.87 | pH 7.5 | Open record: deoxyguanosine kinase (dGK), 2'-deoxyguanosine |
| guanylate kinase (GUK) | Homo sapiens | guanosine monophosphate | 13.88 | 0.016 | 870 | pH 7 | Open record: guanylate kinase (GUK), guanosine monophosphate |
| inosine-guanosine kinase (IGK) | Homo sapiens | guanosine | 0.0065 | 0.0075 | 0.87 | pH 7.5 | Open record: inosine-guanosine kinase (IGK), guanosine |
| NM23H1 (nucleoside diphosphate kinase A) | Homo sapiens | adenosine diphosphate | 13.45 | 0.053 | 250 | pH 7.5, 37 °C | Open record: NM23H1 (nucleoside diphosphate kinase A), adenosine diphosphate |
| NM23H1 (nucleoside diphosphate kinase A) | Homo sapiens | GS-441524 5'-diphosphate | 119.1 | 1.995 | 60 | pH 7.5, 37 °C | Open record: NM23H1 (nucleoside diphosphate kinase A), GS-441524 5'-diphosphate |
| NM23H2 (nucleoside diphosphate kinase B) | Homo sapiens | adenosine diphosphate | 22.85 | 0.043 | 530 | pH 7.5, 37 °C | Open record: NM23H2 (nucleoside diphosphate kinase B), adenosine diphosphate |
| NM23H2 (nucleoside diphosphate kinase B) | Homo sapiens | GS-441524 5'-diphosphate | 175.5 | 2.605 | 67 | pH 7.5, 37 °C | Open record: NM23H2 (nucleoside diphosphate kinase B), GS-441524 5'-diphosphate |
| phosphoglycerate kinase (PGK) | Homo sapiens | adenosine diphosphate | 60.92 | 0.0154 | 3.95 × 10³ | pH 7 | Open record: phosphoglycerate kinase (PGK), adenosine diphosphate |
| phosphoglycerate kinase (PGK) | Homo sapiens | GS-441524 5'-diphosphate | 3.788 | 0.035 | 108.2 | pH 7 | Open record: phosphoglycerate kinase (PGK), GS-441524 5'-diphosphate |
| pyruvate kinase LR (PKLR) | Homo sapiens | adenosine diphosphate | 52.95 | 0.201 | 263 | pH 6.5 | Open record: pyruvate kinase LR (PKLR), adenosine diphosphate |
| pyruvate kinase LR (PKLR) | Homo sapiens | GS-441524 5'-diphosphate | 0.435 | 0.2186 | 2 | pH 6.5 | Open record: pyruvate kinase LR (PKLR), GS-441524 5'-diphosphate |
| pyruvate kinase M2 (PKM2) | Homo sapiens | adenosine diphosphate | 449.5 | 0.3 | 1.5 × 10³ | pH 6.5 | Open record: pyruvate kinase M2 (PKM2), adenosine diphosphate |
| pyruvate kinase M2 (PKM2) | Homo sapiens | GS-441524 5'-diphosphate | 16.3 | 0.4335 | 37.7 | pH 6.5 | Open record: pyruvate kinase M2 (PKM2), GS-441524 5'-diphosphate |
| thymidine kinase 1 (TK1) | Homo sapiens | thymidine | 0.222 | 0.0014 | 158 | pH 7.5 | Open record: thymidine kinase 1 (TK1), thymidine |
| thymidine kinase 2 (TK2) | Homo sapiens | thymidine | 0.115 | 0.0081 | 14.2 | pH 7.5 | Open record: thymidine kinase 2 (TK2), thymidine |
| thymidylate kinase (TMPK) | Homo sapiens | thymidine monophosphate | 0.0043 | 0.0329 | 0.13 | pH 7.5 | Open record: thymidylate kinase (TMPK), thymidine monophosphate |
| uridine cytidine kinase 1 (UCK1) | Homo sapiens | uridine | 1.577 | 0.581 | 2.7 | pH 7.5 | Open record: uridine cytidine kinase 1 (UCK1), uridine |
| uridine cytidine kinase 2 (UCK2) | Homo sapiens | uridine | 36.98 | 0.0786 | 470 | pH 7.5 | Open record: uridine cytidine kinase 2 (UCK2), uridine |