EC 2.7.1.48: uridine/cytidine kinase
TransferasesOpen in Browse
CatLog read 41 records for EC 2.7.1.48 from 3 papers, for 2 organisms. Names in these papers: uridine-cytidine kinase (ttCK), uridine-cytidine kinase homologue (ttCK), uridine-cytidine kinase 2 (hsUCK2), uridine cytidine kinase 1 (UCK1) and 1 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 19 records for EC 2.7.1.48 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.1.48 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Indispensable residue for uridine binding in the uridine-cytidine kinase family | Homo sapiens, Thermus thermophilus | 29 |
| A single amino acid limits the substrate specificity of Thermus thermophilus uridine-cytidine kinase to cytidine | Thermus thermophilus | 10 |
| Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metabolite | Homo sapiens | 2 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| uridine cytidine kinase 1 (UCK1) | Homo sapiens | uridine | 1.577 | 0.581 | 2.7 | pH 7.5 | PMID 42363837 | Open record: uridine cytidine kinase 1 (UCK1), uridine |
| uridine cytidine kinase 2 (UCK2) | Homo sapiens | uridine | 36.98 | 0.0786 | 470 | pH 7.5 | PMID 42363837 | Open record: uridine cytidine kinase 2 (UCK2), uridine |
| uridine-cytidine kinase (ttCK)variant Y93A | Thermus thermophilus | cytidine | 4.5 | 0.383 | 12 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93A, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93A | Thermus thermophilus | uridine | — | — | 0.051 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93A, uridine |
| uridine-cytidine kinase (ttCK)variant Y93C | Thermus thermophilus | cytidine | 1.9 | 0.215 | 9 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93C, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93C | Thermus thermophilus | uridine | — | — | 0.023 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93C, uridine |
| uridine-cytidine kinase (ttCK)variant Y93D | Thermus thermophilus | cytidine | 1.4 | 0.236 | 5.8 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93D, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93D | Thermus thermophilus | uridine | — | — | 0.056 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93D, uridine |
| uridine-cytidine kinase (ttCK)variant Y93E | Thermus thermophilus | cytidine | 1.5 | 0.186 | 5.8 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93E, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93E | Thermus thermophilus | uridine | — | — | 0.056 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93E, uridine |
| uridine-cytidine kinase (ttCK)variant Y93G | Thermus thermophilus | cytidine | 2.9 | 0.62 | 4.6 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93G, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93G | Thermus thermophilus | uridine | — | — | 0.043 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93G, uridine |
| uridine-cytidine kinase (ttCK)variant Y93I | Thermus thermophilus | cytidine | 2.9 | 0.574 | 5.1 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93I, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93I | Thermus thermophilus | uridine | — | — | 0.092 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93I, uridine |
| uridine-cytidine kinase (ttCK)variant Y93M | Thermus thermophilus | cytidine | 7.2 | 0.95 | 7.7 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93M, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93M | Thermus thermophilus | uridine | — | — | 0.048 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93M, uridine |
| uridine-cytidine kinase (ttCK)variant Y93N | Thermus thermophilus | cytidine | 4.1 | 0.47 | 8.7 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93N, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93N | Thermus thermophilus | uridine | — | — | 0.041 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93N, uridine |
| uridine-cytidine kinase (ttCK)variant Y93P | Thermus thermophilus | cytidine | 4.6 | 0.555 | 8.3 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93P, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93P | Thermus thermophilus | uridine | — | — | 0.097 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93P, uridine |
| uridine-cytidine kinase (ttCK)variant Y93S | Thermus thermophilus | cytidine | 7.1 | 0.225 | 32 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93S, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93S | Thermus thermophilus | uridine | — | — | 0.29 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93S, uridine |
| uridine-cytidine kinase (ttCK)variant Y93T | Thermus thermophilus | cytidine | 3.1 | 0.587 | 5.3 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93T, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93T | Thermus thermophilus | uridine | — | — | 0.61 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93T, uridine |
| uridine-cytidine kinase (ttCK)variant Y93V | Thermus thermophilus | cytidine | 3.9 | 0.965 | 4.1 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93V, cytidine |
| uridine-cytidine kinase (ttCK)variant Y93V | Thermus thermophilus | uridine | — | — | 0.079 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93V, uridine |
| uridine-cytidine kinase (ttCK)variant Y93W | Thermus thermophilus | cytidine | 0.4 | 0.071 | 6 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase (ttCK) variant Y93W, cytidine |
| uridine-cytidine kinase 2 (hsUCK2) | Homo sapiens | cytidine | 4.3 | 0.042 | 100 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase 2 (hsUCK2), cytidine |
| uridine-cytidine kinase 2 (hsUCK2) | Homo sapiens | uridine | 5.2 | 0.058 | 90 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase 2 (hsUCK2), uridine |
| uridine-cytidine kinase 2 (hsUCK2)variant H117Y | Homo sapiens | cytidine | 6.4 | 0.138 | 47 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase 2 (hsUCK2) variant H117Y, cytidine |
| uridine-cytidine kinase 2 (hsUCK2)variant H117Y | Homo sapiens | uridine | — | — | 0.96 | pH 7.2, 25 °C | PMID 28955773 | Open record: uridine-cytidine kinase 2 (hsUCK2) variant H117Y, uridine |
| uridine-cytidine kinase homologue (ttCK) | Thermus thermophilus | cytidine | 4.1 | 0.072 | 57 | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK), cytidine |
| uridine-cytidine kinase homologue (ttCK)variant Y59F | Thermus thermophilus | cytidine | 6.4 | 0.2 | 32 | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK) variant Y59F, cytidine |
| uridine-cytidine kinase homologue (ttCK)variant Y93F | Thermus thermophilus | cytidine | 5.9 | 0.1 | 57 | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK) variant Y93F, cytidine |
| uridine-cytidine kinase homologue (ttCK)variant Y93F | Thermus thermophilus | uridine | — | — | 1.2 × 10⁻⁵ | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK) variant Y93F, uridine |
| uridine-cytidine kinase homologue (ttCK)variant Y93H | Thermus thermophilus | cytidine | 8.4 | 0.22 | 38 | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK) variant Y93H, cytidine |
| uridine-cytidine kinase homologue (ttCK)variant Y93H | Thermus thermophilus | uridine | 9.2 | 0.36 | 26 | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK) variant Y93H, uridine |
| uridine-cytidine kinase homologue (ttCK)variant Y93L | Thermus thermophilus | cytidine | 10 | 0.42 | 24 | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK) variant Y93L, cytidine |
| uridine-cytidine kinase homologue (ttCK)variant Y93L | Thermus thermophilus | uridine | — | — | 6.6 × 10⁻⁶ | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK) variant Y93L, uridine |
| uridine-cytidine kinase homologue (ttCK)variant Y93Q | Thermus thermophilus | cytidine | 2.8 | 0.23 | 12 | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK) variant Y93Q, cytidine |
| uridine-cytidine kinase homologue (ttCK)variant Y93Q | Thermus thermophilus | uridine | 1.1 | 1.6 | 0.72 | pH 7.2, 25 °C | PMID 21539325 | Open record: uridine-cytidine kinase homologue (ttCK) variant Y93Q, uridine |