EC 2.7.1.74: deoxycytidine kinase

TransferasesOpen in Browse

CatLog read 176 records for EC 2.7.1.74 from 10 papers, for 4 organisms. Names in these papers: deoxycytidine kinase (dCK), deoxycytidine kinase, GgdCK, GgdCK2 and 4 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 27 records for EC 2.7.1.74 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.1.74 in Browse.

Papers

Papers with records for EC 2.7.1.74
PaperOrganismsRecords
Systematic exploration of active site mutations on human deoxycytidine kinase substrate specificityHomo sapiens44
Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analoguesHomo sapiens25
Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganizationHomo sapiens24
Gene duplications and losses among vertebrate deoxyribonucleoside kinases of the non-TK1 FamilyGallus gallus, Xenopus laevis20
Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinaseHomo sapiens19
Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinaseHomo sapiens16
Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cellsHomo sapiens16
Structure of human dCK suggests strategies to improve anticancer and antiviral therapyHomo sapiens8
Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteriaStaphylococcus aureus3
Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metaboliteHomo sapiens1

Records

Records for EC 2.7.1.74 read from the paper
EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaperOpen record
deoxycytidine kinaseHomo sapiens1-beta-D-arabinofuranosylcytosineATP·Mg fixed at 1 mM (1000 µM); cosubstrate ATP0.30.006943pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, 1-beta-D-arabinofuranosylcytosine
deoxycytidine kinaseHomo sapiens1-beta-D-arabinofuranosylcytosineUTP·Mg fixed at 1 mM (1000 µM); cosubstrate UTP0.170.002763pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, 1-beta-D-arabinofuranosylcytosine
deoxycytidine kinaseHomo sapiens2'-deoxyadenosineATP·Mg fixed at 1 mM (1000 µM); cosubstrate ATP1.70.117pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, 2'-deoxyadenosine
deoxycytidine kinaseHomo sapiens2'-deoxyadenosineUTP·Mg fixed at 1 mM (1000 µM); cosubstrate UTP0.330.01325pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, 2'-deoxyadenosine
deoxycytidine kinaseHomo sapiens2'-deoxycytidineATP·Mg fixed at 1 mM (1000 µM); cosubstrate ATP0.033——pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, 2'-deoxycytidine
deoxycytidine kinaseHomo sapiens2'-deoxycytidineUTP·Mg fixed at 1 mM (1000 µM); cosubstrate UTP0.044——pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, 2'-deoxycytidine
deoxycytidine kinaseHomo sapiens2'-deoxyguanosineATP·Mg fixed at 1 mM (1000 µM); cosubstrate ATP2.60.23111pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, 2'-deoxyguanosine
deoxycytidine kinaseHomo sapiens2'-deoxyguanosineUTP·Mg fixed at 1 mM (1000 µM); cosubstrate UTP0.330.02116pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, 2'-deoxyguanosine
deoxycytidine kinaseHomo sapiensadenosine 5'-triphosphateacceptor dC fixed at 100 µM; cosubstrate dC0.0280.00358pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, adenosine 5'-triphosphate
deoxycytidine kinaseHomo sapiensadenosine 5'-triphosphateacceptor AraC fixed at 250 µM; cosubstrate AraC0.40.0934.3pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, adenosine 5'-triphosphate
deoxycytidine kinaseHomo sapiensAraC0.340.013126pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, AraC
deoxycytidine kinaseHomo sapienscytarabine0.320.005954.2pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, cytarabine
deoxycytidine kinaseHomo sapiensdeoxyadenosine0.770.11696.6pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, deoxyadenosine
deoxycytidine kinaseHomo sapiensdeoxyadenosine2.130.114618.6pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, deoxyadenosine
deoxycytidine kinaseHomo sapiensdeoxycytidine0.040.001723.1pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, deoxycytidine
deoxycytidine kinaseHomo sapiensdeoxycytidine0.04——pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, deoxycytidine
deoxycytidine kinaseHomo sapiensdeoxyguanosine0.730.24582.9pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, deoxyguanosine
deoxycytidine kinaseHomo sapiensdeoxyguanosine2.60.23111.3pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, deoxyguanosine
deoxycytidine kinaseHomo sapiensgemcitabine0.440.006271pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, gemcitabine
deoxycytidine kinaseHomo sapiensgemcitabine0.390.016124.2pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, gemcitabine
deoxycytidine kinaseHomo sapiensuridine 5'-triphosphateacceptor dC fixed at 100 µM; cosubstrate dC0.0310.002314pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, uridine 5'-triphosphate
deoxycytidine kinaseHomo sapiensuridine 5'-triphosphateacceptor AraC fixed at 250 µM; cosubstrate AraC0.0930.019.3pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase, uridine 5'-triphosphate
deoxycytidine kinasevariant R104L/D133AHomo sapiensAraC0.790.050615.6pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, AraC
deoxycytidine kinasevariant R104L/D133AHomo sapiensdeoxyadenosine5.720.162335.2pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, deoxyadenosine
deoxycytidine kinasevariant R104L/D133AHomo sapiensdeoxycytidine0.250.00831.3pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, deoxycytidine
deoxycytidine kinasevariant R104L/D133AHomo sapiensdeoxyguanosine3.662.2661.6pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, deoxyguanosine
deoxycytidine kinasevariant R104L/D133AHomo sapiensgemcitabine2.010.033859.5pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, gemcitabine
deoxycytidine kinasevariant R104L/D133AHomo sapiensL-deoxythymidine1.330.017874.7pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, L-deoxythymidine
deoxycytidine kinasevariant R104L/D133AHomo sapiensthymidine3.20.0243131.7pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, thymidine
deoxycytidine kinasevariant R104M/D133AHomo sapiensAraC1.430.136510.5pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, AraC
deoxycytidine kinasevariant R104M/D133AHomo sapiensdeoxyadenosine4.511.044.3pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, deoxyadenosine
deoxycytidine kinasevariant R104M/D133AHomo sapiensdeoxycytidine1.80.0057315.8pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, deoxycytidine
deoxycytidine kinasevariant R104M/D133AHomo sapiensdeoxyguanosine1.731.8650.9pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, deoxyguanosine
deoxycytidine kinasevariant R104M/D133AHomo sapiensgemcitabine2.680.056247.7pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, gemcitabine
deoxycytidine kinasevariant R104M/D133AHomo sapiensL-deoxythymidine3.130.13822.7pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, L-deoxythymidine
deoxycytidine kinasevariant R104M/D133AHomo sapiensthymidine1.740.14412.1pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, thymidine
deoxycytidine kinasevariant S74AHomo sapienscytarabine0.33——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, cytarabine
deoxycytidine kinasevariant S74AHomo sapiensdeoxyadenosine1.12——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, deoxyadenosine
deoxycytidine kinasevariant S74AHomo sapiensdeoxycytidine0.04——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, deoxycytidine
deoxycytidine kinasevariant S74AHomo sapiensdeoxyguanosine0.68——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, deoxyguanosine
deoxycytidine kinasevariant S74AHomo sapiensgemcitabine0.5——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, gemcitabine
deoxycytidine kinasevariant S74DHomo sapienscytarabine0.57——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, cytarabine
deoxycytidine kinasevariant S74DHomo sapiensdeoxyadenosine1——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, deoxyadenosine
deoxycytidine kinasevariant S74DHomo sapiensdeoxycytidine0.16——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, deoxycytidine
deoxycytidine kinasevariant S74DHomo sapiensdeoxyguanosine0.57——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, deoxyguanosine
deoxycytidine kinasevariant S74DHomo sapiensgemcitabine0.9——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, gemcitabine
deoxycytidine kinasevariant S74EHomo sapienscytarabine1.060.024144pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, cytarabine
deoxycytidine kinasevariant S74EHomo sapiensdeoxyadenosine0.690.51791.3pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, deoxyadenosine
deoxycytidine kinasevariant S74EHomo sapiensdeoxycytidine0.450.008950.6pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, deoxycytidine
deoxycytidine kinasevariant S74EHomo sapiensdeoxyguanosine0.360.60180.6pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, deoxyguanosine
deoxycytidine kinasevariant S74EHomo sapiensgemcitabine1.210.01580.7pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, gemcitabine
deoxycytidine kinasevariant S74QHomo sapienscytarabine0.3——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, cytarabine
deoxycytidine kinasevariant S74QHomo sapiensdeoxyadenosine0.9——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, deoxyadenosine
deoxycytidine kinasevariant S74QHomo sapiensdeoxycytidine0.04——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, deoxycytidine
deoxycytidine kinasevariant S74QHomo sapiensdeoxyguanosine0.65——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, deoxyguanosine
deoxycytidine kinasevariant S74QHomo sapiensgemcitabine0.45——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, gemcitabine
deoxycytidine kinasevariant Δ65-79Homo sapiens1-beta-D-arabinofuranosylcytosineATP·Mg fixed at 1 mM (1000 µM); cosubstrate ATP0.410.01332pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, 1-beta-D-arabinofuranosylcytosine
deoxycytidine kinasevariant Δ65-79Homo sapiens1-beta-D-arabinofuranosylcytosineUTP·Mg fixed at 1 mM (1000 µM); cosubstrate UTP0.150.002854pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, 1-beta-D-arabinofuranosylcytosine
deoxycytidine kinasevariant Δ65-79Homo sapiens2'-deoxyadenosineATP·Mg fixed at 1 mM (1000 µM); cosubstrate ATP2.80.4156.7pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, 2'-deoxyadenosine
deoxycytidine kinasevariant Δ65-79Homo sapiens2'-deoxyadenosineUTP·Mg fixed at 1 mM (1000 µM); cosubstrate UTP0.310.0535.9pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, 2'-deoxyadenosine
deoxycytidine kinasevariant Δ65-79Homo sapiens2'-deoxycytidineATP·Mg fixed at 1 mM (1000 µM); cosubstrate ATP0.0490.001436pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, 2'-deoxycytidine
deoxycytidine kinasevariant Δ65-79Homo sapiens2'-deoxycytidineUTP·Mg fixed at 1 mM (1000 µM); cosubstrate UTP0.088——pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, 2'-deoxycytidine
deoxycytidine kinasevariant Δ65-79Homo sapiens2'-deoxyguanosineATP·Mg fixed at 1 mM (1000 µM); cosubstrate ATP2.20.4744.6pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, 2'-deoxyguanosine
deoxycytidine kinasevariant Δ65-79Homo sapiens2'-deoxyguanosineUTP·Mg fixed at 1 mM (1000 µM); cosubstrate UTP0.320.0873.7pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, 2'-deoxyguanosine
deoxycytidine kinasevariant Δ65-79Homo sapiensadenosine 5'-triphosphateacceptor dC fixed at 100 µM; cosubstrate dC0.0390.002913pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, adenosine 5'-triphosphate
deoxycytidine kinasevariant Δ65-79Homo sapiensadenosine 5'-triphosphateacceptor AraC fixed at 250 µM; cosubstrate AraC0.360.0536.8pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, adenosine 5'-triphosphate
deoxycytidine kinasevariant Δ65-79Homo sapiensuridine 5'-triphosphateacceptor dC fixed at 100 µM; cosubstrate dC0.0410.001527pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, uridine 5'-triphosphate
deoxycytidine kinasevariant Δ65-79Homo sapiensuridine 5'-triphosphateacceptor AraC fixed at 250 µM; cosubstrate AraC0.0750.004716pH 7.5, 37 °CPMID 16401075Open record: deoxycytidine kinase variant Δ65-79, uridine 5'-triphosphate
deoxycytidine kinase (dCK)Homo sapiens2',3'-dideoxycytidine0.180.40680.4pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), 2',3'-dideoxycytidine
deoxycytidine kinase (dCK)Homo sapiens2'-deoxyadenosine3.10.08138pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK), 2'-deoxyadenosine
deoxycytidine kinase (dCK)Homo sapiens2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.033——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), 2'-deoxycytidine
deoxycytidine kinase (dCK)Homo sapiens2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.049——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), 2'-deoxycytidine
deoxycytidine kinase (dCK)Homo sapiens2'-deoxycytidine0.0640.00163pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK), 2'-deoxycytidine
deoxycytidine kinase (dCK)Homo sapiens2'-deoxyguanosine3.260.15421pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK), 2'-deoxyguanosine
deoxycytidine kinase (dCK)Homo sapiens2′-deoxycytidine2 mM ATP as phosphoryl donor; cosubstrate ATP0.0157 × 10⁻⁵236pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK), 2′-deoxycytidine
deoxycytidine kinase (dCK)Homo sapiens2′-deoxycytidine2 mM UTP as phosphoryl donor; cosubstrate UTP0.0219 × 10⁻⁵257pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK), 2′-deoxycytidine
deoxycytidine kinase (dCK)Homo sapiensAraC0.260.015516.8pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), AraC
deoxycytidine kinase (dCK)Homo sapienscladribine2 mM ATP as phosphoryl donor; cosubstrate ATP0.1720.002474.3pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK), cladribine
deoxycytidine kinase (dCK)Homo sapienscladribine2 mM UTP as phosphoryl donor; cosubstrate UTP0.08046.5 × 10⁻⁴130pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK), cladribine
deoxycytidine kinase (dCK)Homo sapiensclofarabine2 mM ATP as phosphoryl donor; cosubstrate ATP1.110.02250.1pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK), clofarabine
deoxycytidine kinase (dCK)Homo sapiensclofarabine2 mM UTP as phosphoryl donor; cosubstrate UTP0.4860.008756.3pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK), clofarabine
deoxycytidine kinase (dCK)Homo sapienscytidine0.740.38271.9pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), cytidine
deoxycytidine kinase (dCK)Homo sapiensdeoxycytidine0.030.00624.8pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), deoxycytidine
deoxycytidine kinase (dCK)Homo sapiensfludarabine2 mM ATP as phosphoryl donor; cosubstrate ATP1.3340.453pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK), fludarabine
deoxycytidine kinase (dCK)Homo sapiensfludarabine2 mM UTP as phosphoryl donor; cosubstrate UTP0.1770.0286.4pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK), fludarabine
deoxycytidine kinase (dCK)Homo sapiensgemcitabine0.370.02216.8pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), gemcitabine
deoxycytidine kinase (dCK)Homo sapiensL-2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.012——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), L-2'-deoxycytidine
deoxycytidine kinase (dCK)Homo sapiensL-2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.01——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), L-2'-deoxycytidine
deoxycytidine kinase (dCK)Homo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.030.00348.8pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), lamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidine
deoxycytidine kinase (dCK)Homo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.1020.00812.8pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), lamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidine
deoxycytidine kinase (dCK)Homo sapiensthymidine0.383.4850.095pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK), thymidine
deoxycytidine kinase (dCK)Homo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.0950.01327.2pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), troxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidine
deoxycytidine kinase (dCK)Homo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.1790.010616.9pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), troxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidine
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiens2'-deoxyadenosine3.40.5986pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiens2'-deoxycytidine1.20.00154777pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiens2'-deoxyguanosine0.311.3640.23pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiensAraC1.730.10217pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, AraC
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiensdeoxycytidine0.930.004232.5pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, deoxycytidine
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiensgemcitabine3.520.0570.4pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, gemcitabine
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiensthymidine3.290.0314105pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, thymidine
deoxycytidine kinase (dCK)variant A100V/R104M/D133SHomo sapiens2'-deoxyadenosine3.370.8434pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133S, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant A100V/R104M/D133SHomo sapiens2'-deoxycytidine2.10.00525400pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133S, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant A100V/R104M/D133SHomo sapiens2'-deoxyguanosine1.720.7392pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133S, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant A100V/R104M/D133SHomo sapiensthymidine1.910.00558342pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133S, thymidine
deoxycytidine kinase (dCK)variant A100V/R104M/D133THomo sapiens2'-deoxyadenosine2.671.4372pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133T, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant A100V/R104M/D133THomo sapiens2'-deoxycytidine3.540.07150pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133T, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant A100V/R104M/D133THomo sapiens2'-deoxyguanosine2.291.1642pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133T, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant A100V/R104M/D133THomo sapiensthymidine1.570.00388406pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133T, thymidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiens2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.1730.00357.7pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiens2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.217——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiensL-2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.036——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, L-2'-deoxycytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiensL-2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.042——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, L-2'-deoxycytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.0280.00843.3pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, lamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.0720.01494.8pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, lamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.1920.05683.4pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, troxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.5240.05789.1pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, troxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidine
deoxycytidine kinase (dCK)variant D47E/R104Q/D133G/N163I/F242LHomo sapiens2'-deoxyadenosine1.080.09112pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant D47E/R104Q/D133G/N163I/F242L, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant D47E/R104Q/D133G/N163I/F242LHomo sapiens2'-deoxycytidine0.210.00141150pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant D47E/R104Q/D133G/N163I/F242L, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant D47E/R104Q/D133G/N163I/F242LHomo sapiens2'-deoxyguanosine1.180.07915pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant D47E/R104Q/D133G/N163I/F242L, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant D47E/R104Q/D133G/N163I/F242LHomo sapiensthymidine0.680.02527pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant D47E/R104Q/D133G/N163I/F242L, thymidine
deoxycytidine kinase (dCK)variant R104M/D133AHomo sapiens2'-deoxyadenosine2.710.4127pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133A, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant R104M/D133AHomo sapiens2'-deoxycytidine0.580.002287pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133A, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant R104M/D133AHomo sapiens2'-deoxyguanosine1.231.280.96pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133A, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant R104M/D133AHomo sapiensthymidine1.880.07425pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133A, thymidine
deoxycytidine kinase (dCK)variant R104M/D133NHomo sapiens2'-deoxyadenosine3.470.4528pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133N, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant R104M/D133NHomo sapiens2'-deoxycytidine2.230.0118189pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133N, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant R104M/D133NHomo sapiens2'-deoxyguanosine3.590.32411pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133N, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant R104M/D133NHomo sapiensthymidine2.270.025688pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133N, thymidine
deoxycytidine kinase (dCK)variant R104M/D133SHomo sapiens2'-deoxyadenosine4.850.39812pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133S, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant R104M/D133SHomo sapiens2'-deoxycytidine1.70.00455373pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133S, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant R104M/D133SHomo sapiens2'-deoxyguanosine4.381.1744pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133S, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant R104M/D133SHomo sapiensthymidine2.330.0189123pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133S, thymidine
deoxycytidine kinase (dCK)variant R104M/D133THomo sapiens2'-deoxyadenosine4.140.6916pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133T, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant R104M/D133THomo sapiens2'-deoxycytidine2.860.0209137pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133T, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant R104M/D133THomo sapiens2'-deoxyguanosine2.51.2032pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133T, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant R104M/D133THomo sapiensthymidine1.490.0058258pH 7.5, 37 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104M/D133T, thymidine
deoxycytidine kinase (dCK)variant R104Q/D133GHomo sapiens2'-deoxyadenosine1.750.2318pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104Q/D133G, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant R104Q/D133GHomo sapiens2'-deoxycytidine0.370.00104356pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104Q/D133G, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant R104Q/D133GHomo sapiens2'-deoxyguanosine1.50.08119pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104Q/D133G, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant R104Q/D133GHomo sapiensthymidine1.010.025739pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104Q/D133G, thymidine
deoxycytidine kinase (dCK)variant R104Q/D133NHomo sapiens2'-deoxyadenosine20.5324pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104Q/D133N, 2'-deoxyadenosine
deoxycytidine kinase (dCK)variant R104Q/D133NHomo sapiens2'-deoxycytidine1.30.0086152pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104Q/D133N, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant R104Q/D133NHomo sapiens2'-deoxyguanosine1.920.248pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104Q/D133N, 2'-deoxyguanosine
deoxycytidine kinase (dCK)variant R104Q/D133NHomo sapiensthymidine1.510.03642pH 7.5, 30 °CPMID 18361501Open record: deoxycytidine kinase (dCK) variant R104Q/D133N, thymidine
deoxycytidine kinase (dCK)variant S74EHomo sapiens2′-deoxycytidine2 mM ATP as phosphoryl donor; cosubstrate ATP0.1832.7 × 10⁻⁴676pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK) variant S74E, 2′-deoxycytidine
deoxycytidine kinase (dCK)variant S74EHomo sapiens2′-deoxycytidine2 mM UTP as phosphoryl donor; cosubstrate UTP0.1231.8 × 10⁻⁴745pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK) variant S74E, 2′-deoxycytidine
deoxycytidine kinase (dCK)variant S74EHomo sapienscladribine2 mM ATP as phosphoryl donor; cosubstrate ATP1.3860.015590.2pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK) variant S74E, cladribine
deoxycytidine kinase (dCK)variant S74EHomo sapienscladribine2 mM UTP as phosphoryl donor; cosubstrate UTP0.2110.0016136pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK) variant S74E, cladribine
deoxycytidine kinase (dCK)variant S74EHomo sapiensclofarabine2 mM ATP as phosphoryl donor; cosubstrate ATP2.450.032576.8pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK) variant S74E, clofarabine
deoxycytidine kinase (dCK)variant S74EHomo sapiensclofarabine2 mM UTP as phosphoryl donor; cosubstrate UTP0.880.015557.6pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK) variant S74E, clofarabine
deoxycytidine kinase (dCK)variant S74EHomo sapiensfludarabine2 mM ATP as phosphoryl donor; cosubstrate ATP1.0050.5511.8pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK) variant S74E, fludarabine
deoxycytidine kinase (dCK)variant S74EHomo sapiensfludarabine2 mM UTP as phosphoryl donor; cosubstrate UTP0.3630.1422.6pH 7.6, 37 °CPMID 22490700Open record: deoxycytidine kinase (dCK) variant S74E, fludarabine
GgdCKGallus gallus2'-deoxyadenosine4.070.09343.8pH 8PMID 27906638Open record: GgdCK, 2'-deoxyadenosine
GgdCKGallus gallus2'-deoxycytidine0.057 × 10⁻⁴65.9pH 8PMID 27906638Open record: GgdCK, 2'-deoxycytidine
GgdCKGallus gallus2'-deoxyguanosine1.230.12210.1pH 8PMID 27906638Open record: GgdCK, 2'-deoxyguanosine
GgdCKGallus gallus2'-deoxyuridine1.057.5020.14pH 8PMID 27906638Open record: GgdCK, 2'-deoxyuridine
GgdCKGallus gallusthymidine1.0818.550.0581pH 8PMID 27906638Open record: GgdCK, thymidine
GgdCK2Gallus gallus2'-deoxyadenosine2.560.10424.6pH 8PMID 27906638Open record: GgdCK2, 2'-deoxyadenosine
GgdCK2Gallus gallus2'-deoxycytidine0.520.0648.21pH 8PMID 27906638Open record: GgdCK2, 2'-deoxycytidine
GgdCK2Gallus gallus2'-deoxyguanosine0.670.019833.7pH 8PMID 27906638Open record: GgdCK2, 2'-deoxyguanosine
GgdCK2Gallus gallus2'-deoxyuridine0.5320.320.0261pH 8PMID 27906638Open record: GgdCK2, 2'-deoxyuridine
GgdCK2Gallus gallusthymidine0.2633.610.00776pH 8PMID 27906638Open record: GgdCK2, thymidine
SadAK (deoxyadenosine kinase)Staphylococcus aureus2',2'-difluoro-2'-deoxycytidine0.190.1920.981pH 8PMID 17526755Open record: SadAK (deoxyadenosine kinase), 2',2'-difluoro-2'-deoxycytidine
SadAK (deoxyadenosine kinase)Staphylococcus aureus2'-deoxyadenosine1.820.029262.2pH 8PMID 17526755Open record: SadAK (deoxyadenosine kinase), 2'-deoxyadenosine
SadAK (deoxyadenosine kinase)Staphylococcus aureus2'-deoxycytidine0.560.034416.2pH 8PMID 17526755Open record: SadAK (deoxyadenosine kinase), 2'-deoxycytidine
thymidine kinase 2 (TK2)Homo sapiensthymidine0.1150.008114.2pH 7.5PMID 42363837Open record: thymidine kinase 2 (TK2), thymidine
XldCKXenopus laevis2'-deoxyadenosine2.730.5534.94pH 8PMID 27906638Open record: XldCK, 2'-deoxyadenosine
XldCKXenopus laevis2'-deoxycytidine0.093.4 × 10⁻⁴259pH 8PMID 27906638Open record: XldCK, 2'-deoxycytidine
XldCKXenopus laevis2'-deoxyguanosine3.40.5276.44pH 8PMID 27906638Open record: XldCK, 2'-deoxyguanosine
XldCKXenopus laevis2'-deoxyuridine1.2715.080.084pH 8PMID 27906638Open record: XldCK, 2'-deoxyuridine
XldCKXenopus laevisthymidine0.2912.460.0236pH 8PMID 27906638Open record: XldCK, thymidine
XldCK2Xenopus laevis2'-deoxyadenosine4.87——pH 8PMID 27906638Open record: XldCK2, 2'-deoxyadenosine
XldCK2Xenopus laevis2'-deoxycytidine0.420.5050.829pH 8PMID 27906638Open record: XldCK2, 2'-deoxycytidine
XldCK2Xenopus laevis2'-deoxyguanosine1.260.02159.1pH 8PMID 27906638Open record: XldCK2, 2'-deoxyguanosine
XldCK2Xenopus laevis2'-deoxyuridine0.3620.130.0177pH 8PMID 27906638Open record: XldCK2, 2'-deoxyuridine
XldCK2Xenopus laevisthymidine0.1433.150.00426pH 8PMID 27906638Open record: XldCK2, thymidine