CatLogenzyme kinetics catalog

Values CatLog read from this paper

Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase

PMID 17158155doi:10.1093/nar/gkl1038Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 16 records (34 values) from this paper: deoxycytidine kinase (dCK) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 2.7.1.74, EC 2.7.1.76, EC 2.7.1.113

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
deoxycytidine kinase (dCK)Homo sapiens2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.033——pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)Homo sapiens2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.049——pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)Homo sapiensL-2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.012——pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)Homo sapiensL-2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.01——pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)Homo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.030.00348.8pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)Homo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.1020.00812.8pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)Homo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.0950.01327.2pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)Homo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.1790.010616.9pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiens2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.1730.00357.7pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiens2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.217——pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiensL-2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.036——pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiensL-2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.042——pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.0280.00843.3pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.0720.01494.8pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.1920.05683.4pH 7.5, 37 °COpen
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.5240.05789.1pH 7.5, 37 °COpen