EC 2.7.1.76: 2'-deoxyadenosine kinase

TransferasesOpen in Browse

CatLog read 84 records for EC 2.7.1.76 from 7 papers, for 5 organisms. Names in these papers: deoxycytidine kinase, deoxycytidine kinase (dCK), GgdCK2, XldCK2 and 2 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 14 records for EC 2.7.1.76 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.1.76 in Browse.

Papers

Papers with records for EC 2.7.1.76
PaperOrganismsRecords
Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analoguesHomo sapiens25
Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinaseHomo sapiens19
Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinaseHomo sapiens16
Gene duplications and losses among vertebrate deoxyribonucleoside kinases of the non-TK1 FamilyGallus gallus, Xenopus laevis10
Structure of human dCK suggests strategies to improve anticancer and antiviral therapyHomo sapiens8
Dictyostelium discoideum salvages purine deoxyribonucleosides by highly specific bacterial-like deoxyribonucleoside kinasesDictyostelium discoideum3
Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteriaStaphylococcus aureus3

Records

Records for EC 2.7.1.76 read from the paper
EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaperOpen record
deoxyadenosine kinase (DddAK)Dictyostelium discoideum2'-deoxyadenosine3.70.0227160PMID 17448496Open record: deoxyadenosine kinase (DddAK), 2'-deoxyadenosine
deoxyadenosine kinase (DddAK)Dictyostelium discoideum9-beta-D-arabinofuranosyl-2-fluoroadenine (fludarabine)3.30.14623PMID 17448496Open record: deoxyadenosine kinase (DddAK), 9-beta-D-arabinofuranosyl-2-fluoroadenine (fludarabine)
deoxyadenosine kinase (DddAK)Dictyostelium discoideumthymidine0.00810.0042PMID 17448496Open record: deoxyadenosine kinase (DddAK), thymidine
deoxycytidine kinaseHomo sapiensAraC0.340.013126pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, AraC
deoxycytidine kinaseHomo sapienscytarabine0.320.005954.2pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, cytarabine
deoxycytidine kinaseHomo sapiensdeoxyadenosine0.770.11696.6pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, deoxyadenosine
deoxycytidine kinaseHomo sapiensdeoxyadenosine2.130.114618.6pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, deoxyadenosine
deoxycytidine kinaseHomo sapiensdeoxycytidine0.040.001723.1pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, deoxycytidine
deoxycytidine kinaseHomo sapiensdeoxycytidine0.04——pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, deoxycytidine
deoxycytidine kinaseHomo sapiensdeoxyguanosine0.730.24582.9pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, deoxyguanosine
deoxycytidine kinaseHomo sapiensdeoxyguanosine2.60.23111.3pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, deoxyguanosine
deoxycytidine kinaseHomo sapiensgemcitabine0.440.006271pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase, gemcitabine
deoxycytidine kinaseHomo sapiensgemcitabine0.390.016124.2pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase, gemcitabine
deoxycytidine kinasevariant R104L/D133AHomo sapiensAraC0.790.050615.6pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, AraC
deoxycytidine kinasevariant R104L/D133AHomo sapiensdeoxyadenosine5.720.162335.2pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, deoxyadenosine
deoxycytidine kinasevariant R104L/D133AHomo sapiensdeoxycytidine0.250.00831.3pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, deoxycytidine
deoxycytidine kinasevariant R104L/D133AHomo sapiensdeoxyguanosine3.662.2661.6pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, deoxyguanosine
deoxycytidine kinasevariant R104L/D133AHomo sapiensgemcitabine2.010.033859.5pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, gemcitabine
deoxycytidine kinasevariant R104L/D133AHomo sapiensL-deoxythymidine1.330.017874.7pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, L-deoxythymidine
deoxycytidine kinasevariant R104L/D133AHomo sapiensthymidine3.20.0243131.7pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104L/D133A, thymidine
deoxycytidine kinasevariant R104M/D133AHomo sapiensAraC1.430.136510.5pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, AraC
deoxycytidine kinasevariant R104M/D133AHomo sapiensdeoxyadenosine4.511.044.3pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, deoxyadenosine
deoxycytidine kinasevariant R104M/D133AHomo sapiensdeoxycytidine1.80.0057315.8pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, deoxycytidine
deoxycytidine kinasevariant R104M/D133AHomo sapiensdeoxyguanosine1.731.8650.9pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, deoxyguanosine
deoxycytidine kinasevariant R104M/D133AHomo sapiensgemcitabine2.680.056247.7pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, gemcitabine
deoxycytidine kinasevariant R104M/D133AHomo sapiensL-deoxythymidine3.130.13822.7pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, L-deoxythymidine
deoxycytidine kinasevariant R104M/D133AHomo sapiensthymidine1.740.14412.1pH 7.5, 37 °CPMID 19159229Open record: deoxycytidine kinase variant R104M/D133A, thymidine
deoxycytidine kinasevariant S74AHomo sapienscytarabine0.33——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, cytarabine
deoxycytidine kinasevariant S74AHomo sapiensdeoxyadenosine1.12——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, deoxyadenosine
deoxycytidine kinasevariant S74AHomo sapiensdeoxycytidine0.04——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, deoxycytidine
deoxycytidine kinasevariant S74AHomo sapiensdeoxyguanosine0.68——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, deoxyguanosine
deoxycytidine kinasevariant S74AHomo sapiensgemcitabine0.5——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74A, gemcitabine
deoxycytidine kinasevariant S74DHomo sapienscytarabine0.57——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, cytarabine
deoxycytidine kinasevariant S74DHomo sapiensdeoxyadenosine1——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, deoxyadenosine
deoxycytidine kinasevariant S74DHomo sapiensdeoxycytidine0.16——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, deoxycytidine
deoxycytidine kinasevariant S74DHomo sapiensdeoxyguanosine0.57——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, deoxyguanosine
deoxycytidine kinasevariant S74DHomo sapiensgemcitabine0.9——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74D, gemcitabine
deoxycytidine kinasevariant S74EHomo sapienscytarabine1.060.024144pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, cytarabine
deoxycytidine kinasevariant S74EHomo sapiensdeoxyadenosine0.690.51791.3pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, deoxyadenosine
deoxycytidine kinasevariant S74EHomo sapiensdeoxycytidine0.450.008950.6pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, deoxycytidine
deoxycytidine kinasevariant S74EHomo sapiensdeoxyguanosine0.360.60180.6pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, deoxyguanosine
deoxycytidine kinasevariant S74EHomo sapiensgemcitabine1.210.01580.7pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74E, gemcitabine
deoxycytidine kinasevariant S74QHomo sapienscytarabine0.3——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, cytarabine
deoxycytidine kinasevariant S74QHomo sapiensdeoxyadenosine0.9——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, deoxyadenosine
deoxycytidine kinasevariant S74QHomo sapiensdeoxycytidine0.04——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, deoxycytidine
deoxycytidine kinasevariant S74QHomo sapiensdeoxyguanosine0.65——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, deoxyguanosine
deoxycytidine kinasevariant S74QHomo sapiensgemcitabine0.45——pH 7.5, 25 °CPMID 18258203Open record: deoxycytidine kinase variant S74Q, gemcitabine
deoxycytidine kinase (dCK)Homo sapiens2',3'-dideoxycytidine0.180.40680.4pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), 2',3'-dideoxycytidine
deoxycytidine kinase (dCK)Homo sapiens2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.033——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), 2'-deoxycytidine
deoxycytidine kinase (dCK)Homo sapiens2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.049——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), 2'-deoxycytidine
deoxycytidine kinase (dCK)Homo sapiensAraC0.260.015516.8pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), AraC
deoxycytidine kinase (dCK)Homo sapienscytidine0.740.38271.9pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), cytidine
deoxycytidine kinase (dCK)Homo sapiensdeoxycytidine0.030.00624.8pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), deoxycytidine
deoxycytidine kinase (dCK)Homo sapiensgemcitabine0.370.02216.8pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK), gemcitabine
deoxycytidine kinase (dCK)Homo sapiensL-2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.012——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), L-2'-deoxycytidine
deoxycytidine kinase (dCK)Homo sapiensL-2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.01——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), L-2'-deoxycytidine
deoxycytidine kinase (dCK)Homo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.030.00348.8pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), lamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidine
deoxycytidine kinase (dCK)Homo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.1020.00812.8pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), lamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidine
deoxycytidine kinase (dCK)Homo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.0950.01327.2pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), troxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidine
deoxycytidine kinase (dCK)Homo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.1790.010616.9pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK), troxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidine
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiensAraC1.730.10217pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, AraC
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiensdeoxycytidine0.930.004232.5pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, deoxycytidine
deoxycytidine kinase (dCK)variant A100V/R104M/D133AHomo sapiensgemcitabine3.520.0570.4pH 7.5, 37 °CPMID 12808445Open record: deoxycytidine kinase (dCK) variant A100V/R104M/D133A, gemcitabine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiens2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.1730.00357.7pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiens2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.217——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, 2'-deoxycytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiensL-2'-deoxycytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.036——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, L-2'-deoxycytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapiensL-2'-deoxycytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.042——pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, L-2'-deoxycytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.0280.00843.3pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, lamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienslamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.0720.01494.8pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, lamivudine, (-)-L-beta-2',3'-dideoxy-3'-thiacytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor ATP-Mg 1 mM; cosubstrate ATP0.1920.05683.4pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, troxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidine
deoxycytidine kinase (dCK)variant C9S/C45S/C59S/C146SHomo sapienstroxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidinephosphoryl donor UTP-Mg 1 mM; cosubstrate UTP0.5240.05789.1pH 7.5, 37 °CPMID 17158155Open record: deoxycytidine kinase (dCK) variant C9S/C45S/C59S/C146S, troxacitabine, (-)-L-beta-2',3'-dideoxy-3'-oxacytidine
GgdCK2Gallus gallus2'-deoxyadenosine2.560.10424.6pH 8PMID 27906638Open record: GgdCK2, 2'-deoxyadenosine
GgdCK2Gallus gallus2'-deoxycytidine0.520.0648.21pH 8PMID 27906638Open record: GgdCK2, 2'-deoxycytidine
GgdCK2Gallus gallus2'-deoxyguanosine0.670.019833.7pH 8PMID 27906638Open record: GgdCK2, 2'-deoxyguanosine
GgdCK2Gallus gallus2'-deoxyuridine0.5320.320.0261pH 8PMID 27906638Open record: GgdCK2, 2'-deoxyuridine
GgdCK2Gallus gallusthymidine0.2633.610.00776pH 8PMID 27906638Open record: GgdCK2, thymidine
SadAK (deoxyadenosine kinase)Staphylococcus aureus2',2'-difluoro-2'-deoxycytidine0.190.1920.981pH 8PMID 17526755Open record: SadAK (deoxyadenosine kinase), 2',2'-difluoro-2'-deoxycytidine
SadAK (deoxyadenosine kinase)Staphylococcus aureus2'-deoxyadenosine1.820.029262.2pH 8PMID 17526755Open record: SadAK (deoxyadenosine kinase), 2'-deoxyadenosine
SadAK (deoxyadenosine kinase)Staphylococcus aureus2'-deoxycytidine0.560.034416.2pH 8PMID 17526755Open record: SadAK (deoxyadenosine kinase), 2'-deoxycytidine
XldCK2Xenopus laevis2'-deoxyadenosine4.87——pH 8PMID 27906638Open record: XldCK2, 2'-deoxyadenosine
XldCK2Xenopus laevis2'-deoxycytidine0.420.5050.829pH 8PMID 27906638Open record: XldCK2, 2'-deoxycytidine
XldCK2Xenopus laevis2'-deoxyguanosine1.260.02159.1pH 8PMID 27906638Open record: XldCK2, 2'-deoxyguanosine
XldCK2Xenopus laevis2'-deoxyuridine0.3620.130.0177pH 8PMID 27906638Open record: XldCK2, 2'-deoxyuridine
XldCK2Xenopus laevisthymidine0.1433.150.00426pH 8PMID 27906638Open record: XldCK2, thymidine