Values CatLog read from this paper
Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells
PMID 22490700doi:10.1016/j.bcp.2012.03.022Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 16 records (48 values) from this paper: deoxycytidine kinase (dCK) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| deoxycytidine kinase (dCK) | Homo sapiens | 2′-deoxycytidine2 mM ATP as phosphoryl donor; cosubstrate ATP | 0.015 | 7 × 10⁻⁵ | 236 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK), 2′-deoxycytidine |
| deoxycytidine kinase (dCK) | Homo sapiens | 2′-deoxycytidine2 mM UTP as phosphoryl donor; cosubstrate UTP | 0.021 | 9 × 10⁻⁵ | 257 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK), 2′-deoxycytidine |
| deoxycytidine kinase (dCK) | Homo sapiens | cladribine2 mM ATP as phosphoryl donor; cosubstrate ATP | 0.172 | 0.0024 | 74.3 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK), cladribine |
| deoxycytidine kinase (dCK) | Homo sapiens | cladribine2 mM UTP as phosphoryl donor; cosubstrate UTP | 0.0804 | 6.5 × 10⁻⁴ | 130 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK), cladribine |
| deoxycytidine kinase (dCK) | Homo sapiens | clofarabine2 mM ATP as phosphoryl donor; cosubstrate ATP | 1.11 | 0.022 | 50.1 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK), clofarabine |
| deoxycytidine kinase (dCK) | Homo sapiens | clofarabine2 mM UTP as phosphoryl donor; cosubstrate UTP | 0.486 | 0.0087 | 56.3 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK), clofarabine |
| deoxycytidine kinase (dCK) | Homo sapiens | fludarabine2 mM ATP as phosphoryl donor; cosubstrate ATP | 1.334 | 0.45 | 3 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK), fludarabine |
| deoxycytidine kinase (dCK) | Homo sapiens | fludarabine2 mM UTP as phosphoryl donor; cosubstrate UTP | 0.177 | 0.028 | 6.4 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK), fludarabine |
| deoxycytidine kinase (dCK)variant S74E | Homo sapiens | 2′-deoxycytidine2 mM ATP as phosphoryl donor; cosubstrate ATP | 0.183 | 2.7 × 10⁻⁴ | 676 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK) variant S74E, 2′-deoxycytidine |
| deoxycytidine kinase (dCK)variant S74E | Homo sapiens | 2′-deoxycytidine2 mM UTP as phosphoryl donor; cosubstrate UTP | 0.123 | 1.8 × 10⁻⁴ | 745 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK) variant S74E, 2′-deoxycytidine |
| deoxycytidine kinase (dCK)variant S74E | Homo sapiens | cladribine2 mM ATP as phosphoryl donor; cosubstrate ATP | 1.386 | 0.0155 | 90.2 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK) variant S74E, cladribine |
| deoxycytidine kinase (dCK)variant S74E | Homo sapiens | cladribine2 mM UTP as phosphoryl donor; cosubstrate UTP | 0.211 | 0.0016 | 136 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK) variant S74E, cladribine |
| deoxycytidine kinase (dCK)variant S74E | Homo sapiens | clofarabine2 mM ATP as phosphoryl donor; cosubstrate ATP | 2.45 | 0.0325 | 76.8 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK) variant S74E, clofarabine |
| deoxycytidine kinase (dCK)variant S74E | Homo sapiens | clofarabine2 mM UTP as phosphoryl donor; cosubstrate UTP | 0.88 | 0.0155 | 57.6 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK) variant S74E, clofarabine |
| deoxycytidine kinase (dCK)variant S74E | Homo sapiens | fludarabine2 mM ATP as phosphoryl donor; cosubstrate ATP | 1.005 | 0.551 | 1.8 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK) variant S74E, fludarabine |
| deoxycytidine kinase (dCK)variant S74E | Homo sapiens | fludarabine2 mM UTP as phosphoryl donor; cosubstrate UTP | 0.363 | 0.142 | 2.6 | pH 7.6, 37 °C | Open record: deoxycytidine kinase (dCK) variant S74E, fludarabine |