Values CatLog read from this paper
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates
PMID 21128666doi:10.1021/jm1011462Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 14 records (39 values) from this paper: thymidylate kinase (TMP kinase) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 3 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-3-dihydroxyphosphonyl-prop-2-enyl]-thymine | 0.6 | 1 | 0.6 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-3-dihydroxyphosphonyl-prop-2-enyl]-thymine |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-bromouracil | 0.9 | 0.02 | 45 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-bromouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-chlorouracil | 0.5 | 0.13 | 4.1 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-chlorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-fluorouracil | 0.73 | 1 | 0.73 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-5-fluorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-thymine | 0.84 | 0.024 | 35 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-thymine |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-uracil | 0.48 | 1.7 | 0.28 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-4-dihydroxyphosphonyl-but-2-enyl]-uracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-bromouracil | 0.058 | 0.16 | 0.36 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-bromouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-chlorouracil | 0.1 | 0.15 | 0.66 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-chlorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-fluorouracil | 0.09 | 1.9 | 0.047 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-5-fluorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-thymine | 0.32 | 0.1 | 3.2 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-thymine |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-uracil | 0.074 | 2.5 | 0.03 | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(E)-5-dihydroxyphosphonyl-pent-2-enyl]-uracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-5-bromouracil | 0.2 | 0.4 | 0.50 calc. | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-5-bromouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-5-fluorouracil | 0.037 | 0.3 | 0.12 calc. | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-5-fluorouracil |
| thymidylate kinase (TMP kinase) | Homo sapiens | N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-uracil | 0.12 | 0.55 | 0.22 calc. | pH 7.4, 37 °C | Open record: thymidylate kinase (TMP kinase), N1-[(Z)-4-dihydroxyphosphonyl-but-2-enyl]-uracil |