Values CatLog read from this paper

Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses

PMID 12651859doi:10.1074/jbc.m210113200Open in Browse

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CatLog read 36 records (108 values) from this paper: HIV-1 reverse transcriptase from Human immunodeficiency virus type 1 (HIV-1).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 2.7.7.49

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
HIV-1 reverse transcriptase	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.327	5 × 10⁻⁴	653	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptase	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.212	0.00114	187	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptase	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	2.6	0.00472	552	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant D67N/K70R/T215Y/K219Q	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.332	8.6 × 10⁻⁴	385	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant D67N/K70R/T215Y/K219Q, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant D67N/K70R/T215Y/K219Q	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.275	0.00168	163	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant D67N/K70R/T215Y/K219Q, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant D67N/K70R/T215Y/K219Q	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	1.95	0.006	325	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant D67N/K70R/T215Y/K219Q, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.532	5 × 10⁻⁴	1057	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K103N, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.297	8.2 × 10⁻⁴	362	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K103N, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	1.9	0.00218	875	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K103N, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.258	0.0011	235	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.235	0.00149	158	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	0.95	0.00306	312	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R/K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.507	0.00128	395	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R/K103N, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R/K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.645	9.6 × 10⁻⁴	675	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R/K103N, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R/K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	3.38	0.00333	1018	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R/K103N, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R/K103N/Q151M	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.31	0.00149	207	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R/K103N/Q151M, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R/K103N/Q151M	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.382	6.5 × 10⁻⁴	588	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R/K103N/Q151M, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R/K103N/Q151M	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	3.28	0.00439	748	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R/K103N/Q151M, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R/Q151M	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.215	9.5 × 10⁻⁴	227	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R/Q151M, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R/Q151M	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.385	0.00118	325	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R/Q151M, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant K65R/Q151M	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	2.45	0.0044	555	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant K65R/Q151M, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant L74V	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.337	4.5 × 10⁻⁴	755	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant L74V, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant L74V	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.312	0.00134	233	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant L74V, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant L74V	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	1.2	0.00273	442	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant L74V, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant L74V/K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.21	2.1 × 10⁻⁴	978	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant L74V/K103N, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant L74V/K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.193	3 × 10⁻⁴	648	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant L74V/K103N, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant L74V/K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	2.02	0.0024	842	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant L74V/K103N, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant M184V	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.25	7.3 × 10⁻⁴	343	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant M184V, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant M184V	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.392	0.00114	343	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant M184V, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant M184V	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	2.05	0.0047	437	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant M184V, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant Q151M	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.227	7.3 × 10⁻⁴	310	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant Q151M, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant Q151M	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.245	4 × 10⁻⁴	617	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant Q151M, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant Q151M	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	2.77	0.00578	478	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant Q151M, 2'-deoxythymidine 5'-triphosphate
HIV-1 reverse transcriptasevariant Q151M/K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxycytidine 5'-triphosphate	0.145	7.5 × 10⁻⁴	193	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant Q151M/K103N, 2'-deoxycytidine 5'-triphosphate
HIV-1 reverse transcriptasevariant Q151M/K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxyguanosine 5'-triphosphate	0.218	5.5 × 10⁻⁴	398	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant Q151M/K103N, 2'-deoxyguanosine 5'-triphosphate
HIV-1 reverse transcriptasevariant Q151M/K103N	Human immunodeficiency virus type 1 (HIV-1)	2'-deoxythymidine 5'-triphosphate	2.7	0.00388	697	pH 7.8, 37 °C	Open record: HIV-1 reverse transcriptase variant Q151M/K103N, 2'-deoxythymidine 5'-triphosphate