Values CatLog read from this paper
Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases
PMID 15274642doi:10.1021/bi049592eOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 21 records (36 values) from this paper: SIRT2 (human homologue of Sir2), yeast Sir2 (ySir2), HST2 (yeast homologue of Sir2) from Saccharomyces cerevisiae, Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| HST2 (yeast homologue of Sir2) | Saccharomyces cerevisiae | acetylated histone H3 peptide ARTKQTARKSTGG(AcK)APRKQ (acetyl-Lys14) | — | 2.8 × 10⁻⁴ | 718 | Open record: HST2 (yeast homologue of Sir2), acetylated histone H3 peptide ARTKQTARKSTGG(AcK)APRKQ (acetyl-Lys14) | |
| HST2 (yeast homologue of Sir2) | Saccharomyces cerevisiae | acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | — | 0.0043 | 56.7 | Open record: HST2 (yeast homologue of Sir2), acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | |
| HST2 (yeast homologue of Sir2) | Saccharomyces cerevisiae | monoacetylated histone H3/H4 peptides (average over peptides) | 0.32 | — | — | Open record: HST2 (yeast homologue of Sir2), monoacetylated histone H3/H4 peptides (average over peptides) | |
| HST2 (yeast homologue of Sir2) | Saccharomyces cerevisiae | NAD+ | — | 0.0023 | — | Open record: HST2 (yeast homologue of Sir2), NAD+ | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H3 peptide ARTKQTAR(AcK)STGGKAPRKQL (acetyl-Lys9) | — | 0.024 | 10 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H3 peptide ARTKQTAR(AcK)STGGKAPRKQL (acetyl-Lys9) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H3 peptide ARTKQTARKSTGG(AcK)APRKQ (acetyl-Lys14) | — | 0.054 | 3.93 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H3 peptide ARTKQTARKSTGG(AcK)APRKQ (acetyl-Lys14) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | — | 0.09 | 1.3 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H4 peptide SGRG(AcK)GGKGLGKGGAKRHRK (acetyl-Lys5) | — | 0.048 | 3.6 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H4 peptide SGRG(AcK)GGKGLGKGGAKRHRK (acetyl-Lys5) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H4 peptide SGRGKGG(AcK)GLGKGGAKRHRK (acetyl-Lys8) | — | 0.0249 | 7.2 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H4 peptide SGRGKGG(AcK)GLGKGGAKRHRK (acetyl-Lys8) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H4 peptide SGRGKGGKGLG(AcK)GGAKRHRK (acetyl-Lys12) | — | 0.141 | 2.9 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H4 peptide SGRGKGGKGLG(AcK)GGAKRHRK (acetyl-Lys12) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H4 peptide SGRGKGGKGLGKGGA(AcK)RHRK (acetyl-Lys16) | — | 0.0255 | 9.4 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H4 peptide SGRGKGGKGLGKGGA(AcK)RHRK (acetyl-Lys16) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | monoacetylated histone H3/H4 peptides (average over peptides) | 0.24 | — | — | Open record: SIRT2 (human homologue of Sir2), monoacetylated histone H3/H4 peptides (average over peptides) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | NAD+ | — | 0.0826 | — | pH 7.5, 37 °C | Open record: SIRT2 (human homologue of Sir2), NAD+ |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H3 peptide ARTKQTAR(AcK)STGGKAPRKQL (acetyl-Lys9) | — | — | 2.8 | Open record: yeast Sir2 (ySir2), acetylated histone H3 peptide ARTKQTAR(AcK)STGGKAPRKQL (acetyl-Lys9) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | — | 0.42 | 1.6 | Open record: yeast Sir2 (ySir2), acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H4 peptide SGRG(AcK)GGKGLGKGGAKRHRK (acetyl-Lys5) | — | 0.14 | 4.2 | Open record: yeast Sir2 (ySir2), acetylated histone H4 peptide SGRG(AcK)GGKGLGKGGAKRHRK (acetyl-Lys5) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H4 peptide SGRGKGG(AcK)GLGKGGAKRHRK (acetyl-Lys8) | — | 0.054 | 12.8 | Open record: yeast Sir2 (ySir2), acetylated histone H4 peptide SGRGKGG(AcK)GLGKGGAKRHRK (acetyl-Lys8) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H4 peptide SGRGKGGKGLG(AcK)GGAKRHRK (acetyl-Lys12) | 0.085 | 0.105 | 0.81 | Open record: yeast Sir2 (ySir2), acetylated histone H4 peptide SGRGKGGKGLG(AcK)GGAKRHRK (acetyl-Lys12) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H4 peptide SGRGKGGKGLGKGGA(AcK)RHRK (acetyl-Lys16) | — | 0.017 | 43.8 | Open record: yeast Sir2 (ySir2), acetylated histone H4 peptide SGRGKGGKGLGKGGA(AcK)RHRK (acetyl-Lys16) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | monoacetylated histone peptides AcH3(K14) 11-mer, AcH4(K5), AcH4(K8), AcH4(K16) (average over peptides) | 0.67 | — | — | Open record: yeast Sir2 (ySir2), monoacetylated histone peptides AcH3(K14) 11-mer, AcH4(K5), AcH4(K8), AcH4(K16) (average over peptides) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | NAD+ | — | 0.0293 | — | Open record: yeast Sir2 (ySir2), NAD+ |