EC 2.3.1.286: protein acetyllysine N-acetyltransferase
TransferasesOpen in Browse
CatLog read 80 records for EC 2.3.1.286 from 4 papers, for 3 organisms. Names in these papers: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), SIRT1 (SIRT1-143 construct), SIRT2 (human homologue of Sir2) and 3 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 25 records for EC 2.3.1.286 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.3.1.286 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Substrate Specificity and Kinetic Mechanism of the NAD+-Dependent Deacylase from Mycobacterium tuberculosis, Rv1151c (Mt-Sirt) | Mycobacterium tuberculosis | 42 |
| Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases | Homo sapiens, Saccharomyces cerevisiae | 21 |
| The Effects of Phosphorylation on the Structure and Function of Motif A, an Intrinsically Disordered Region within SIRT1 | Homo sapiens | 10 |
| ICEKAT: an interactive online tool for calculating initial rates from continuous enzyme kinetic traces | Homo sapiens | 7 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| HST2 (yeast homologue of Sir2) | Saccharomyces cerevisiae | acetylated histone H3 peptide ARTKQTARKSTGG(AcK)APRKQ (acetyl-Lys14) | — | 2.8 × 10⁻⁴ | 718 | PMID 15274642 | Open record: HST2 (yeast homologue of Sir2), acetylated histone H3 peptide ARTKQTARKSTGG(AcK)APRKQ (acetyl-Lys14) | |
| HST2 (yeast homologue of Sir2) | Saccharomyces cerevisiae | acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | — | 0.0043 | 56.7 | PMID 15274642 | Open record: HST2 (yeast homologue of Sir2), acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | |
| HST2 (yeast homologue of Sir2) | Saccharomyces cerevisiae | monoacetylated histone H3/H4 peptides (average over peptides) | 0.32 | — | — | PMID 15274642 | Open record: HST2 (yeast homologue of Sir2), monoacetylated histone H3/H4 peptides (average over peptides) | |
| HST2 (yeast homologue of Sir2) | Saccharomyces cerevisiae | NAD+ | — | 0.0023 | — | PMID 15274642 | Open record: HST2 (yeast homologue of Sir2), NAD+ | |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH | — | 0.03 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHNAD+ fixed at 1 mM; apparent Km | — | 0.057 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHNAD+ fixed at 1 mM; apparent Km | — | 0.062 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHNAD+ fixed at 1 mM; apparent Km | — | 0.046 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHNAD+ fixed at 1 mM; apparent Km | — | 0.14 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH | — | 0.11 | — | pH 8, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) | Mycobacterium tuberculosis | carbobenzyloxy-(Nε-acetyl)lysine-7-amino-4-methylcoumarin | — | — | 0.062 | pH 8.5 | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), carbobenzyloxy-(Nε-acetyl)lysine-7-amino-4-methylcoumarin |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) | Mycobacterium tuberculosis | carbobenzyloxy-(Nε-propionyl)lysine-7-amino-4-methylcoumarin | — | — | 0.017 | pH 8.5 | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), carbobenzyloxy-(Nε-propionyl)lysine-7-amino-4-methylcoumarin |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) | Mycobacterium tuberculosis | carbobenzyloxy-(Nε-succinyl)lysine-7-amino-4-methylcoumarin | — | — | 0.59 | pH 8.5 | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase), carbobenzyloxy-(Nε-succinyl)lysine-7-amino-4-methylcoumarin |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase)variant R56M | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH | 0.1 | 0.2 | 0.5 | pH 8, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) variant R56M, Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase)variant Y53F | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OHTable 2 | 0.058 | 1.9 | 0.03 | pH 8, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) variant Y53F, Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase)variant Y53F | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OHSupplementary Figure S4 | 0.022 | 0.63 | 0.035 calc. | pH 8, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) variant Y53F, Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH |
| Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase)variant Y53F | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH | 0.09 | 0.26 | 0.32 | pH 8, 37 °C | PMID 42441379 | Open record: Mt-Sirt (Rv1151c, NAD+-dependent lysine deacylase) variant Y53F, Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-acetyl)-Ile-Trp-OH | 0.112 | 1.1 | 0.11 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-acetyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-butyryl)-Ile-Trp-OH | 0.017 | 1.3 | 0.013 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-butyryl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-crotonyl)-Ile-Trp-OH | 0.007 | 4 | 0.0017 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-crotonyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-decanoyl)-Ile-Trp-OH | 0.023 | 0.024 | 0.95 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-decanoyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-dodecanoyl)-Ile-Trp-OH | 0.047 | 0.042 | 1.1 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-dodecanoyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-glutaryl)-Ile-Trp-OH | 0.055 | 0.11 | 0.52 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-glutaryl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-hexanoyl)-Ile-Trp-OH | 0.017 | 0.1 | 0.017 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-hexanoyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-malonyl)-Ile-Trp-OH | 0.048 | 1.4 | 0.036 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-malonyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-myristoyl)-Ile-Trp-OH | 0.031 | 0.018 | 1.8 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-myristoyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-octanoyl)-Ile-Trp-OH | 0.036 | 0.18 | 0.19 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-octanoyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-palmitoyl)-Ile-Trp-OH | 0.016 | 0.008 | 2 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-palmitoyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH | 0.078 | 0.41 | 0.19 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHsaturating NAD+ (1 mM); variable acyl peptide (0-1.5 mM) | 0.157 | 0.042 | 3.8 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH | — | 0.03 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHproduct inhibition by nicotinamide (NAM, 0-400 µM) | — | 0.057 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHproduct inhibition by nicotinamide (NAM, 0-400 µM) | — | 0.062 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHdead-end inhibition by ADP-ribose (ADPR, 0-5000 µM) | — | 0.046 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHdead-end inhibition by Cbz-Lys-AMC (0-2000 µM); apparent Km | — | 0.14 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OHNAD+ fixed at 1 mM; HPLC assay | — | 0.11 | — | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | carbobenzyloxy-(Nε-acetyl)lysine-7-amino-4-methylcoumarin | 0.009 | 0.157 | 0.057 calc. | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), carbobenzyloxy-(Nε-acetyl)lysine-7-amino-4-methylcoumarin | |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | carbobenzyloxy-(Nε-succinyl)lysine-7-amino-4-methylcoumarin | 0.015 | 0.0165 | 0.91 calc. | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), carbobenzyloxy-(Nε-succinyl)lysine-7-amino-4-methylcoumarin | |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | NAD+product inhibition by nicotinamide (NAM, 0-800 µM) | — | 0.24 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), NAD+ |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | NAD+dead-end inhibition by ADP-ribose (ADPR, 0-5000 µM) | — | 0.26 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), NAD+ |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | NAD+dead-end inhibition by Cbz-Lys-AMC (0-2000 µM) | — | 0.77 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), NAD+ |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c) | Mycobacterium tuberculosis | NAD+dead-end inhibition by Cbz-Lys-AMC (0-2000 µM) | — | 0.12 | — | pH 7.5, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c), NAD+ |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c)variant R56M | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH | 0.1 | 0.2 | 0.5 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c) variant R56M, Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c)variant Y53F | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OHTable 2 | 0.058 | 1.9 | 0.03 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c) variant Y53F, Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c)variant Y53F | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OHin the text | 0.022 | — | — | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c) variant Y53F, Ac-Arg-Ser-Gly-Lys(Nε-propionyl)-Ile-Trp-OH |
| NAD+-dependent deacylase Mt-Sirt (Rv1151c)variant Y53F | Mycobacterium tuberculosis | Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH | 0.09 | 0.26 | 0.32 | pH 8, 37 °C | PMID 42441379 | Open record: NAD+-dependent deacylase Mt-Sirt (Rv1151c) variant Y53F, Ac-Arg-Ser-Gly-Lys(Nε-succinyl)-Ile-Trp-OH |
| SIRT1 (NAD+-dependent protein deacetylase sirtuin-1) | Homo sapiens | H2N-RHKK(acetyl)W-CONH2no activator | — | 0.014 | 8.662 | pH 7.5, 25 °C | PMID 32410570 | Open record: SIRT1 (NAD+-dependent protein deacetylase sirtuin-1), H2N-RHKK(acetyl)W-CONH2 |
| SIRT1 (NAD+-dependent protein deacetylase sirtuin-1) | Homo sapiens | H2N-RHKK(acetyl)W-CONH2with saturating resveratrol (50 or 100 µM) | — | 0.004 | 23.27 | pH 7.5, 25 °C | PMID 32410570 | Open record: SIRT1 (NAD+-dependent protein deacetylase sirtuin-1), H2N-RHKK(acetyl)W-CONH2 |
| SIRT1 (NAD+-dependent protein deacetylase sirtuin-1) | Homo sapiens | H2N-RHKK(acetyl)W-CONH2with 50 µM STAC1 | — | 0.007 | 15.87 | pH 7.5, 25 °C | PMID 32410570 | Open record: SIRT1 (NAD+-dependent protein deacetylase sirtuin-1), H2N-RHKK(acetyl)W-CONH2 |
| SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)variant D292A | Homo sapiens | H2N-RHKK(acetyl)W-CONH2with saturating resveratrol (50 or 100 µM) | — | 0.023 | — | pH 7.5, 25 °C | PMID 32410570 | Open record: SIRT1 (NAD+-dependent protein deacetylase sirtuin-1) variant D292A, H2N-RHKK(acetyl)W-CONH2 |
| SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)variant D292A | Homo sapiens | H2N-RHKK(acetyl)W-CONH2no activator | — | 0.062 | — | pH 7.5, 25 °C | PMID 32410570 | Open record: SIRT1 (NAD+-dependent protein deacetylase sirtuin-1) variant D292A, H2N-RHKK(acetyl)W-CONH2 |
| SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)variant E230K | Homo sapiens | H2N-RHKK(acetyl)W-CONH2with 50 µM STAC1 | — | — | 20.68 | pH 7.5, 25 °C | PMID 32410570 | Open record: SIRT1 (NAD+-dependent protein deacetylase sirtuin-1) variant E230K, H2N-RHKK(acetyl)W-CONH2 |
| SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)variant E230K | Homo sapiens | H2N-RHKK(acetyl)W-CONH2no activator | — | — | 5.514 | pH 7.5, 25 °C | PMID 32410570 | Open record: SIRT1 (NAD+-dependent protein deacetylase sirtuin-1) variant E230K, H2N-RHKK(acetyl)W-CONH2 |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSno additive; Table 1 | 0.021 | 0.023 | 0.9 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSTable 1 | 0.022 | 0.024 | 0.9 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSTable 1 | 0.027 | 0.014 | 2 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSTable 1 | 0.038 | 0.023 | 1.7 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSTable 1 | 0.027 | 0.022 | 1.2 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSTable 2 | 0.024 | 0.013 | 1.9 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSTable 2 | 0.025 | 0.013 | 1.9 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSTable 2 | 0.03 | 0.009 | 3.4 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSTable 2 | 0.025 | 0.011 | 2.2 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT1 (SIRT1-143 construct) | Homo sapiens | acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKSTable 2 | 0.02 | 0.011 | 1.8 | pH 7.4, 25 °C | PMID 42610734 | Open record: SIRT1 (SIRT1-143 construct), acetylated p65 13-mer peptide RTYETFK(Ac)SIMKKS |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H3 peptide ARTKQTAR(AcK)STGGKAPRKQL (acetyl-Lys9) | — | 0.024 | 10 | PMID 15274642 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H3 peptide ARTKQTAR(AcK)STGGKAPRKQL (acetyl-Lys9) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H3 peptide ARTKQTARKSTGG(AcK)APRKQ (acetyl-Lys14) | — | 0.054 | 3.93 | PMID 15274642 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H3 peptide ARTKQTARKSTGG(AcK)APRKQ (acetyl-Lys14) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | — | 0.09 | 1.3 | PMID 15274642 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H4 peptide SGRG(AcK)GGKGLGKGGAKRHRK (acetyl-Lys5) | — | 0.048 | 3.6 | PMID 15274642 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H4 peptide SGRG(AcK)GGKGLGKGGAKRHRK (acetyl-Lys5) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H4 peptide SGRGKGG(AcK)GLGKGGAKRHRK (acetyl-Lys8) | — | 0.0249 | 7.2 | PMID 15274642 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H4 peptide SGRGKGG(AcK)GLGKGGAKRHRK (acetyl-Lys8) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H4 peptide SGRGKGGKGLG(AcK)GGAKRHRK (acetyl-Lys12) | — | 0.141 | 2.9 | PMID 15274642 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H4 peptide SGRGKGGKGLG(AcK)GGAKRHRK (acetyl-Lys12) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | acetylated histone H4 peptide SGRGKGGKGLGKGGA(AcK)RHRK (acetyl-Lys16) | — | 0.0255 | 9.4 | PMID 15274642 | Open record: SIRT2 (human homologue of Sir2), acetylated histone H4 peptide SGRGKGGKGLGKGGA(AcK)RHRK (acetyl-Lys16) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | monoacetylated histone H3/H4 peptides (average over peptides) | 0.24 | — | — | PMID 15274642 | Open record: SIRT2 (human homologue of Sir2), monoacetylated histone H3/H4 peptides (average over peptides) | |
| SIRT2 (human homologue of Sir2) | Homo sapiens | NAD+ | — | 0.0826 | — | pH 7.5, 37 °C | PMID 15274642 | Open record: SIRT2 (human homologue of Sir2), NAD+ |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H3 peptide ARTKQTAR(AcK)STGGKAPRKQL (acetyl-Lys9) | — | — | 2.8 | PMID 15274642 | Open record: yeast Sir2 (ySir2), acetylated histone H3 peptide ARTKQTAR(AcK)STGGKAPRKQL (acetyl-Lys9) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | — | 0.42 | 1.6 | PMID 15274642 | Open record: yeast Sir2 (ySir2), acetylated histone H3 peptide KSTGG(AcK)APRKQ (11-mer, acetyl-Lys14) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H4 peptide SGRG(AcK)GGKGLGKGGAKRHRK (acetyl-Lys5) | — | 0.14 | 4.2 | PMID 15274642 | Open record: yeast Sir2 (ySir2), acetylated histone H4 peptide SGRG(AcK)GGKGLGKGGAKRHRK (acetyl-Lys5) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H4 peptide SGRGKGG(AcK)GLGKGGAKRHRK (acetyl-Lys8) | — | 0.054 | 12.8 | PMID 15274642 | Open record: yeast Sir2 (ySir2), acetylated histone H4 peptide SGRGKGG(AcK)GLGKGGAKRHRK (acetyl-Lys8) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H4 peptide SGRGKGGKGLG(AcK)GGAKRHRK (acetyl-Lys12) | 0.085 | 0.105 | 0.81 | PMID 15274642 | Open record: yeast Sir2 (ySir2), acetylated histone H4 peptide SGRGKGGKGLG(AcK)GGAKRHRK (acetyl-Lys12) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | acetylated histone H4 peptide SGRGKGGKGLGKGGA(AcK)RHRK (acetyl-Lys16) | — | 0.017 | 43.8 | PMID 15274642 | Open record: yeast Sir2 (ySir2), acetylated histone H4 peptide SGRGKGGKGLGKGGA(AcK)RHRK (acetyl-Lys16) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | monoacetylated histone peptides AcH3(K14) 11-mer, AcH4(K5), AcH4(K8), AcH4(K16) (average over peptides) | 0.67 | — | — | PMID 15274642 | Open record: yeast Sir2 (ySir2), monoacetylated histone peptides AcH3(K14) 11-mer, AcH4(K5), AcH4(K8), AcH4(K16) (average over peptides) | |
| yeast Sir2 (ySir2) | Saccharomyces cerevisiae | NAD+ | — | 0.0293 | — | PMID 15274642 | Open record: yeast Sir2 (ySir2), NAD+ |