CatLogenzyme kinetics catalog

Values CatLog read from this paper

ICEKAT: an interactive online tool for calculating initial rates from continuous enzyme kinetic traces

PMID 32410570doi:10.1186/s12859-020-3513-yOpen in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 7 records (10 values) from this paper: SIRT1 (NAD+-dependent protein deacetylase sirtuin-1) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 2.3.1.286

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)Homo sapiensH2N-RHKK(acetyl)W-CONH2no activator—0.0148.662pH 7.5, 25 °COpen
SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)Homo sapiensH2N-RHKK(acetyl)W-CONH2with saturating resveratrol (50 or 100 µM)—0.00423.27pH 7.5, 25 °COpen
SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)Homo sapiensH2N-RHKK(acetyl)W-CONH2with 50 µM STAC1—0.00715.87pH 7.5, 25 °COpen
SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)variant D292AHomo sapiensH2N-RHKK(acetyl)W-CONH2with saturating resveratrol (50 or 100 µM)—0.023—pH 7.5, 25 °COpen
SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)variant D292AHomo sapiensH2N-RHKK(acetyl)W-CONH2no activator—0.062—pH 7.5, 25 °COpen
SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)variant E230KHomo sapiensH2N-RHKK(acetyl)W-CONH2with 50 µM STAC1——20.68pH 7.5, 25 °COpen
SIRT1 (NAD+-dependent protein deacetylase sirtuin-1)variant E230KHomo sapiensH2N-RHKK(acetyl)W-CONH2no activator——5.514pH 7.5, 25 °COpen