CatLogenzyme kinetics catalog

Values CatLog read from this paper

Xenopus laevis CYP17 regulates androgen biosynthesis independent of the cofactor cytochrome b5

PMID 15640159doi:10.1074/jbc.m411886200Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 27 records (54 values) from this paper: CYP17 (HuCYP17), CYP17 (XeCYP17) from Homo sapiens, Xenopus laevis.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 27 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.

EC 1.14.14.19, EC 1.14.14.32

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenoloneno cytochrome b5 added0.00132.69 × 10⁻⁴5.0 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.01133.38 × 10⁻⁴34.0 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00172.55 × 10⁻⁴6.5 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.01033.12 × 10⁻⁴33.0 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00672.57 × 10⁻⁴26 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00183.78 × 10⁻⁴4.9 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00174.44 × 10⁻⁴3.8 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00221.91 × 10⁻⁴11 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00481.73 × 10⁻⁴28 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesterone(~150 pmol/ml) wild-type human cytochrome b5 (Hb5)0.00224.41 × 10⁻⁴4.9 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteronehuman/Xenopus chimeric cytochrome b5 H(1-69)Xb50.00225.09 × 10⁻⁴4.3 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteronehuman/Xenopus chimeric cytochrome b5 H(1-50)Xb50.00176.6 × 10⁻⁴2.5 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteronehuman/Xenopus chimeric cytochrome b5 H(1-11)Xb56.7 × 10⁻⁴4.55 × 10⁻⁴1.5 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteroneXenopus/human chimeric cytochrome b5 X(1-55)Hb58.3 × 10⁻⁴4.59 × 10⁻⁴1.8 calc.pH 7.4Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteroneXenopus/human chimeric cytochrome b5 X(1-16)Hb50.0023.22 × 10⁻⁴6.2 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxypregnenoloneno cytochrome b5 added0.00686.34 × 10⁻⁴11 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxypregnenolone0.03272.4 × 10⁻⁴140 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxypregnenolone0.02853.32 × 10⁻⁴85.8 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxyprogesteroneno cytochrome b5 added0.00851.83 × 10⁻⁴46 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxyprogesterone0.02223.13 × 10⁻⁴70.8 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxyprogesterone0.03551.51 × 10⁻⁴235 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevispregnenoloneno cytochrome b5 added0.00332.3 × 10⁻⁵140 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevispregnenolone0.00452.2 × 10⁻⁵200 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevispregnenolone0.00674.4 × 10⁻⁵150 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevisprogesteroneno cytochrome b5 added0.05238.56 × 10⁻⁴61.1 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevisprogesterone0.05126.97 × 10⁻⁴73.4 calc.pH 7.4Open
CYP17 (XeCYP17)Xenopus laevisprogesterone0.06426.74 × 10⁻⁴95.2 calc.pH 7.4Open