CatLogenzyme kinetics catalog

EC 1.14.14.19: steroid 17alpha-monooxygenase

OxidoreductasesOpen in Browse

CatLog read 44 records for EC 1.14.14.19 from 3 papers, for 3 organisms. Names in these papers: CYP17 (HuCYP17), CYP17 (XeCYP17), cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), cytochrome P450 17A1 (zebrafish P450 17A1) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 20 records for EC 1.14.14.19 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.14.19 in Browse.

Papers

PaperOrganismsRecords
Xenopus laevis CYP17 regulates androgen biosynthesis independent of the cofactor cytochrome b5Homo sapiens, Xenopus laevis27
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1Homo sapiens11
Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2Danio rerio6

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenoloneno cytochrome b5 added0.00132.69 × 10⁻⁴5.0 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.01133.38 × 10⁻⁴34.0 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00172.55 × 10⁻⁴6.5 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.01033.12 × 10⁻⁴33.0 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00672.57 × 10⁻⁴26 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00183.78 × 10⁻⁴4.9 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00174.44 × 10⁻⁴3.8 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00221.91 × 10⁻⁴11 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxypregnenolone0.00481.73 × 10⁻⁴28 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesterone(~150 pmol/ml) wild-type human cytochrome b5 (Hb5)0.00224.41 × 10⁻⁴4.9 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteronehuman/Xenopus chimeric cytochrome b5 H(1-69)Xb50.00225.09 × 10⁻⁴4.3 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteronehuman/Xenopus chimeric cytochrome b5 H(1-50)Xb50.00176.6 × 10⁻⁴2.5 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteronehuman/Xenopus chimeric cytochrome b5 H(1-11)Xb56.7 × 10⁻⁴4.55 × 10⁻⁴1.5 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteroneXenopus/human chimeric cytochrome b5 X(1-55)Hb58.3 × 10⁻⁴4.59 × 10⁻⁴1.8 calc.pH 7.4PMID 15640159Open
CYP17 (HuCYP17)Homo sapiens17alpha-hydroxyprogesteroneXenopus/human chimeric cytochrome b5 X(1-16)Hb50.0023.22 × 10⁻⁴6.2 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxypregnenoloneno cytochrome b5 added0.00686.34 × 10⁻⁴11 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxypregnenolone0.03272.4 × 10⁻⁴140 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxypregnenolone0.02853.32 × 10⁻⁴85.8 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxyprogesteroneno cytochrome b5 added0.00851.83 × 10⁻⁴46 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxyprogesterone0.02223.13 × 10⁻⁴70.8 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevis17alpha-hydroxyprogesterone0.03551.51 × 10⁻⁴235 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevispregnenoloneno cytochrome b5 added0.00332.3 × 10⁻⁵140 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevispregnenolone0.00452.2 × 10⁻⁵200 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevispregnenolone0.00674.4 × 10⁻⁵150 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevisprogesteroneno cytochrome b5 added0.05238.56 × 10⁻⁴61.1 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevisprogesterone0.05126.97 × 10⁻⁴73.4 calc.pH 7.4PMID 15640159Open
CYP17 (XeCYP17)Xenopus laevisprogesterone0.06426.74 × 10⁻⁴95.2 calc.pH 7.4PMID 15640159Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapiens17alpha-hydroxypregnenolonewithout cytochrome b50.00595.7 × 10⁻⁴10pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapiens17alpha-hydroxypregnenolonewith 0.5 µM human cytochrome b50.0719.1 × 10⁻⁴78pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapiens17alpha-hydroxyprogesteronewithout cytochrome b53.1 × 10⁻⁴0.00290.11pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapiens17alpha-hydroxyprogesteronewith 0.5 µM human cytochrome b50.0190.00712.7pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapienspregn-4-ene-3,20-dionewithout cytochrome b50.0860.00978.9pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapienspregn-4-ene-3,20-dionewith 0.5 µM human cytochrome b50.170.004340pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapienspregn-4-ene-3,20-dionewithout cytochrome b50.00640.00115.8pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapienspregn-4-ene-3,20-dionewith 0.5 µM human cytochrome b50.0250.00534.7pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapienspregn-5-en-3beta-ol-20-onewithout cytochrome b50.00375 × 10⁻⁴7.4pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapienspregn-5-en-3beta-ol-20-onewith 0.5 µM human cytochrome b50.110.0011100pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase)Homo sapienspregn-5-en-3beta-ol-20-onereaction: lyase (overall conversion of pregnenolone to DHEA)0.0454.9 × 10⁻⁴92pH 7.4, 37 °CPMID 28684414Open
cytochrome P450 17A1 (zebrafish P450 17A1)Danio rerio17alpha-hydroxypregnenolone0.00550.00850.65pH 7.4, 37 °CPMID 25533464Open
cytochrome P450 17A1 (zebrafish P450 17A1)Danio rerio17alpha-hydroxyprogesterone0.020.001118pH 7.4, 37 °CPMID 25533464Open
cytochrome P450 17A1 (zebrafish P450 17A1)Danio reriopregnenolone0.0330.00217pH 7.4, 37 °CPMID 25533464Open
cytochrome P450 17A1 (zebrafish P450 17A1)Danio rerioprogesterone0.0970.001757pH 7.4, 37 °CPMID 25533464Open
cytochrome P450 17A2 (zebrafish P450 17A2)Danio reriopregnenolone0.850.009392pH 7.4, 37 °CPMID 25533464Open
cytochrome P450 17A2 (zebrafish P450 17A2)Danio rerioprogesterone1.580.0353pH 7.4, 37 °CPMID 25533464Open