Values CatLog read from this paper
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1
PMID 28684414doi:10.1074/jbc.m117.794917Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 11 records (33 values) from this paper: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | 17alpha-hydroxypregnenolonewithout cytochrome b5 | 0.0059 | 5.7 × 10⁻⁴ | 10 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), 17alpha-hydroxypregnenolone |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | 17alpha-hydroxypregnenolonewith 0.5 µM human cytochrome b5 | 0.071 | 9.1 × 10⁻⁴ | 78 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), 17alpha-hydroxypregnenolone |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | 17alpha-hydroxyprogesteronewithout cytochrome b5 | 3.1 × 10⁻⁴ | 0.0029 | 0.11 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), 17alpha-hydroxyprogesterone |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | 17alpha-hydroxyprogesteronewith 0.5 µM human cytochrome b5 | 0.019 | 0.0071 | 2.7 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), 17alpha-hydroxyprogesterone |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | pregn-4-ene-3,20-dionewithout cytochrome b5 | 0.086 | 0.0097 | 8.9 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), pregn-4-ene-3,20-dione |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | pregn-4-ene-3,20-dionewith 0.5 µM human cytochrome b5 | 0.17 | 0.0043 | 40 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), pregn-4-ene-3,20-dione |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | pregn-4-ene-3,20-dionewithout cytochrome b5 | 0.0064 | 0.0011 | 5.8 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), pregn-4-ene-3,20-dione |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | pregn-4-ene-3,20-dionewith 0.5 µM human cytochrome b5 | 0.025 | 0.0053 | 4.7 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), pregn-4-ene-3,20-dione |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | pregn-5-en-3beta-ol-20-onewithout cytochrome b5 | 0.0037 | 5 × 10⁻⁴ | 7.4 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), pregn-5-en-3beta-ol-20-one |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | pregn-5-en-3beta-ol-20-onewith 0.5 µM human cytochrome b5 | 0.11 | 0.0011 | 100 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), pregn-5-en-3beta-ol-20-one |
| cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase) | Homo sapiens | pregn-5-en-3beta-ol-20-onereaction: lyase (overall conversion of pregnenolone to DHEA) | 0.045 | 4.9 × 10⁻⁴ | 92 | pH 7.4, 37 °C | Open record: cytochrome P450 17A1 (steroid 17alpha-hydroxylase/17,20-lyase), pregn-5-en-3beta-ol-20-one |