Values CatLog read from this paper
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
PMID 15795226doi:10.1074/jbc.m501100200Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 6 records (8 values) from this paper: dihydroorotate dehydrogenase (pfDHODH) from Plasmodium falciparum.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 2 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| dihydroorotate dehydrogenase (pfDHODH) | Plasmodium falciparum | CoQ_D | 7.8 | 0.016 | 490 calc. | pH 8 | Open record: dihydroorotate dehydrogenase (pfDHODH), CoQ_D |
| dihydroorotate dehydrogenase (pfDHODH) | Plasmodium falciparum | L-dihydroorotate | — | 0.091 | — | pH 8 | Open record: dihydroorotate dehydrogenase (pfDHODH), L-dihydroorotate |
| dihydroorotate dehydrogenase (pfDHODH)variant H185A | Plasmodium falciparum | CoQ_D | — | 0.066 | — | pH 8 | Open record: dihydroorotate dehydrogenase (pfDHODH) variant H185A, CoQ_D |
| dihydroorotate dehydrogenase (pfDHODH)variant H185A | Plasmodium falciparum | L-dihydroorotate | — | 0.123 | — | pH 8 | Open record: dihydroorotate dehydrogenase (pfDHODH) variant H185A, L-dihydroorotate |
| dihydroorotate dehydrogenase (pfDHODH)variant R265A | Plasmodium falciparum | CoQ_D | 4.6 | 0.032 | 140 calc. | pH 8 | Open record: dihydroorotate dehydrogenase (pfDHODH) variant R265A, CoQ_D |
| dihydroorotate dehydrogenase (pfDHODH)variant R265A | Plasmodium falciparum | L-dihydroorotate | — | 0.105 | — | pH 8 | Open record: dihydroorotate dehydrogenase (pfDHODH) variant R265A, L-dihydroorotate |