EC 1.3.5.2: dihydroorotate dehydrogenase (quinone)
OxidoreductasesOpen in Browse
CatLog read 49 records for EC 1.3.5.2 from 3 papers, for 2 organisms. Names in these papers: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase), dihydroorotate dehydrogenase (mitochondrial), dihydroorotate dehydrogenase (pfDHODH).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 76 records for EC 1.3.5.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.3.5.2 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase | Plasmodium falciparum | 37 |
| High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | Plasmodium falciparum | 6 |
| Analysis of the kinetic mechanism of the bovine liver mitochondrial dihydroorotate dehydrogenase | Bos taurus | 6 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| dihydroorotate dehydrogenase (mitochondrial) | Bos taurus | (S)-dihydroorotatealternate-substrate kinetics (Table II) | 50.4 | 0.0092 | 5.5 × 10³ calc. | pH 7.8, 37 °C | PMID 2540819 | Open record: dihydroorotate dehydrogenase (mitochondrial), (S)-dihydroorotate |
| dihydroorotate dehydrogenase (mitochondrial) | Bos taurus | (S)-dihydroorotateinitial velocity pattern | 50.4 | 0.0102 | 4.94 × 10³ calc. | pH 7.8, 37 °C | PMID 2540819 | Open record: dihydroorotate dehydrogenase (mitochondrial), (S)-dihydroorotate |
| dihydroorotate dehydrogenase (mitochondrial) | Bos taurus | coenzyme Q6alternate-substrate kinetics (Table II) | 44.2 | 0.0142 | 3.11 × 10³ calc. | pH 7.8, 37 °C | PMID 2540819 | Open record: dihydroorotate dehydrogenase (mitochondrial), coenzyme Q6 |
| dihydroorotate dehydrogenase (mitochondrial) | Bos taurus | coenzyme Q6initial velocity pattern | — | 0.0166 | — | pH 7.8, 37 °C | PMID 2540819 | Open record: dihydroorotate dehydrogenase (mitochondrial), coenzyme Q6 |
| dihydroorotate dehydrogenase (mitochondrial) | Bos taurus | menadione | 18.3 | 0.1843 | 99.3 calc. | pH 7.8, 37 °C | PMID 2540819 | Open record: dihydroorotate dehydrogenase (mitochondrial), menadione |
| dihydroorotate dehydrogenase (mitochondrial) | Bos taurus | methyl (4S)-2,6-dioxohexahydropyrimidine-4-carboxylate | 45.4 | 0.1542 | 294 calc. | pH 7.8, 37 °C | PMID 2540819 | Open record: dihydroorotate dehydrogenase (mitochondrial), methyl (4S)-2,6-dioxohexahydropyrimidine-4-carboxylate |
| dihydroorotate dehydrogenase (pfDHODH) | Plasmodium falciparum | CoQ_D | 7.8 | 0.016 | 490 calc. | pH 8 | PMID 15795226 | Open record: dihydroorotate dehydrogenase (pfDHODH), CoQ_D |
| dihydroorotate dehydrogenase (pfDHODH) | Plasmodium falciparum | L-dihydroorotate | — | 0.091 | — | pH 8 | PMID 15795226 | Open record: dihydroorotate dehydrogenase (pfDHODH), L-dihydroorotate |
| dihydroorotate dehydrogenase (pfDHODH)variant H185A | Plasmodium falciparum | CoQ_D | — | 0.066 | — | pH 8 | PMID 15795226 | Open record: dihydroorotate dehydrogenase (pfDHODH) variant H185A, CoQ_D |
| dihydroorotate dehydrogenase (pfDHODH)variant H185A | Plasmodium falciparum | L-dihydroorotate | — | 0.123 | — | pH 8 | PMID 15795226 | Open record: dihydroorotate dehydrogenase (pfDHODH) variant H185A, L-dihydroorotate |
| dihydroorotate dehydrogenase (pfDHODH)variant R265A | Plasmodium falciparum | CoQ_D | 4.6 | 0.032 | 140 calc. | pH 8 | PMID 15795226 | Open record: dihydroorotate dehydrogenase (pfDHODH) variant R265A, CoQ_D |
| dihydroorotate dehydrogenase (pfDHODH)variant R265A | Plasmodium falciparum | L-dihydroorotate | — | 0.105 | — | pH 8 | PMID 15795226 | Open record: dihydroorotate dehydrogenase (pfDHODH) variant R265A, L-dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) | Plasmodium falciparum | decylubiquinone | 12 | 0.013 | 920 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase), decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) | Plasmodium falciparum | dihydroorotate | 0.42 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase), dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) | Plasmodium falciparum | ubiquinone-1 | 7.8 | 0.011 | 710 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase), ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) | Plasmodium falciparum | ubiquinone-1 | 6.3 | 0.016 | 390 calc. | pH 8, 4 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase), ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant F188A | Plasmodium falciparum | decylubiquinone | 4.3 | 0.02 | 220 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant F188A, decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant F188A | Plasmodium falciparum | dihydroorotate | 0.53 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant F188A, dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant F188A | Plasmodium falciparum | ubiquinone-1 | 2.6 | 0.015 | 170 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant F188A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant F188A | Plasmodium falciparum | ubiquinone-1 | 2.8 | 0.026 | 110 calc. | pH 8, 4 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant F188A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant F227A | Plasmodium falciparum | decylubiquinone | 3.5 | 0.02 | 180 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant F227A, decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant F227A | Plasmodium falciparum | dihydroorotate | 0.43 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant F227A, dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant F227A | Plasmodium falciparum | ubiquinone-1 | 2.6 | 0.016 | 160 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant F227A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant F227A | Plasmodium falciparum | ubiquinone-1 | 1.7 | 0.018 | 94 calc. | pH 8, 4 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant F227A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant H185A | Plasmodium falciparum | decylubiquinone | 7.9 | 0.034 | 230 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant H185A, decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant H185A | Plasmodium falciparum | dihydroorotate | 0.57 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant H185A, dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant H185A | Plasmodium falciparum | ubiquinone-1 | 7.3 | 0.022 | 330 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant H185A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant H185A | Plasmodium falciparum | ubiquinone-1 | 2.3 | 0.041 | 56 calc. | pH 8, 4 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant H185A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant I272A | Plasmodium falciparum | decylubiquinone | 1.8 | 0.012 | 150 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant I272A, decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant I272A | Plasmodium falciparum | dihydroorotate | 0.083 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant I272A, dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant I272A | Plasmodium falciparum | ubiquinone-1 | 1.5 | 0.0078 | 190 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant I272A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant I272A | Plasmodium falciparum | ubiquinone-1 | 1.1 | 0.015 | 73 calc. | pH 8, 4 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant I272A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant L531A | Plasmodium falciparum | decylubiquinone | 8.6 | 0.016 | 540 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant L531A, decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant L531A | Plasmodium falciparum | dihydroorotate | 0.25 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant L531A, dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant L531A | Plasmodium falciparum | ubiquinone-1 | 5.1 | 0.017 | 300 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant L531A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant R265A | Plasmodium falciparum | decylubiquinone | 5 | 0.026 | 190 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant R265A, decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant R265A | Plasmodium falciparum | dihydroorotate | 0.44 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant R265A, dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant R265A | Plasmodium falciparum | ubiquinone-1 | 3.1 | 0.038 | 82 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant R265A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant R265A | Plasmodium falciparum | ubiquinone-1 | 1.7 | 0.021 | 81 calc. | pH 8, 4 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant R265A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528A | Plasmodium falciparum | decylubiquinone | 0.12 | 0.0088 | 14 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528A, decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528A | Plasmodium falciparum | dihydroorotate | 0.1 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528A, dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528A | Plasmodium falciparum | ubiquinone-1 | 0.19 | 0.016 | 12 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528A | Plasmodium falciparum | ubiquinone-1 | 0.1 | 0.037 | 2.7 calc. | pH 8, 4 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528A, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528F | Plasmodium falciparum | decylubiquinone | 1.2 | 0.053 | 23 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528F, decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528F | Plasmodium falciparum | dihydroorotate | 0.63 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528F, dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528F | Plasmodium falciparum | ubiquinone-1 | 1.9 | 0.02 | 95 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528F, ubiquinone-1 |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528W | Plasmodium falciparum | decylubiquinone | 6.8 | 0.045 | 150 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528W, decylubiquinone |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528W | Plasmodium falciparum | dihydroorotate | 0.18 | — | — | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528W, dihydroorotate |
| pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase)variant Y528W | Plasmodium falciparum | ubiquinone-1 | 5.1 | 0.048 | 110 calc. | pH 8, 25 °C | PMID 18225919 | Open record: pfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) variant Y528W, ubiquinone-1 |