Values CatLog read from this paper
Substrate recognition by the human fatty-acid synthase
PMID 16215233doi:10.1074/jbc.m507082200Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 27 records (65 values) from this paper: fatty-acid synthase (HFAS) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
EC 1.1.1.100, EC 1.3.1.10, EC 2.3.1.85, EC 4.2.1.59
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| fatty-acid synthase (HFAS) | Homo sapiens | acetoacetyl-CoA | 4 | 0.01 | 400 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), acetoacetyl-CoA |
| fatty-acid synthase (HFAS) | Homo sapiens | acetyl-CoA | — | 0.007 | 380 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), acetyl-CoA |
| fatty-acid synthase (HFAS) | Homo sapiens | crotonyl-CoA | 0.1 | 0.007 | 15 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), crotonyl-CoA |
| fatty-acid synthase (HFAS) | Homo sapiens | crotonyl-CoA | 0.33 | 0.006 | 50 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), crotonyl-CoA |
| fatty-acid synthase (HFAS) | Homo sapiens | malonyl-CoA | — | 0.006 | 450 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), malonyl-CoA |
| fatty-acid synthase (HFAS) | Homo sapiens | NADPH | 2.67 | 0.005 | 530 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), NADPH |
| fatty-acid synthase (HFAS) | Homo sapiens | NADPH | — | 0.004 | 1 × 10³ | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), NADPH |
| fatty-acid synthase (HFAS) | Homo sapiens | NADPHcrotonyl-CoA 100 µM fixed; cosubstrate crotonyl-CoA | — | 0.003 | 120 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), NADPH |
| fatty-acid synthase (HFAS) | Homo sapiens | NADPHoctenoyl-CoA fixed; cosubstrate octenoyl-CoA | — | 0.1 | 0.5 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), NADPH |
| fatty-acid synthase (HFAS) | Homo sapiens | NADPHdodecenoyl-CoA 25 µM fixed; cosubstrate dodecenoyl-CoA | — | 0.54 | 0.33 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), NADPH |
| fatty-acid synthase (HFAS) | Homo sapiens | trans-2-dodecenoyl-CoA | 0.22 | 0.007 | 33 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), trans-2-dodecenoyl-CoA |
| fatty-acid synthase (HFAS) | Homo sapiens | trans-2-octenoyl-CoA | 0.05 | — | — | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS), trans-2-octenoyl-CoA |
| fatty-acid synthase (HFAS)variant K1699A | Homo sapiens | acetoacetyl-CoA | 0.33 | 0.002 | 170 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699A, acetoacetyl-CoA |
| fatty-acid synthase (HFAS)variant K1699A | Homo sapiens | acetyl-CoA | — | 0.007 | 50 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699A, acetyl-CoA |
| fatty-acid synthase (HFAS)variant K1699A | Homo sapiens | crotonyl-CoA | 0.4 | 0.04 | 10 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699A, crotonyl-CoA |
| fatty-acid synthase (HFAS)variant K1699A | Homo sapiens | crotonyl-CoA | 0.15 | 0.003 | 50 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699A, crotonyl-CoA |
| fatty-acid synthase (HFAS)variant K1699A | Homo sapiens | malonyl-CoA | — | 0.003 | 100 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699A, malonyl-CoA |
| fatty-acid synthase (HFAS)variant K1699A | Homo sapiens | NADPH | 0.32 | 0.37 | 0.83 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699A, NADPH |
| fatty-acid synthase (HFAS)variant K1699A | Homo sapiens | NADPH | — | 0.052 | 6.5 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699A, NADPH |
| fatty-acid synthase (HFAS)variant K1699A | Homo sapiens | NADPH | — | 0.4 | 0.33 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699A, NADPH |
| fatty-acid synthase (HFAS)variant K1699Q | Homo sapiens | acetoacetyl-CoA | 0.43 | 0.0012 | 370 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699Q, acetoacetyl-CoA |
| fatty-acid synthase (HFAS)variant K1699Q | Homo sapiens | acetyl-CoA | — | 5 × 10⁻⁴ | 600 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699Q, acetyl-CoA |
| fatty-acid synthase (HFAS)variant K1699Q | Homo sapiens | crotonyl-CoA | 0.22 | 0.003 | 67 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699Q, crotonyl-CoA |
| fatty-acid synthase (HFAS)variant K1699Q | Homo sapiens | malonyl-CoA | — | 0.001 | 300 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699Q, malonyl-CoA |
| fatty-acid synthase (HFAS)variant K1699Q | Homo sapiens | NADPH | 0.3 | 0.4 | 0.83 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699Q, NADPH |
| fatty-acid synthase (HFAS)variant K1699Q | Homo sapiens | NADPH | — | 0.123 | 3.5 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699Q, NADPH |
| fatty-acid synthase (HFAS)variant K1699Q | Homo sapiens | NADPH | — | 0.35 | 0.67 | pH 7, 25 °C | Open record: fatty-acid synthase (HFAS) variant K1699Q, NADPH |