EC 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
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CatLog read 20 records for EC 4.2.1.59 from 3 papers, for 3 organisms. Names in these papers: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS), fatty-acid synthase (HFAS), beta-hydroxyacyl-[acyl-carrier-protein] dehydrase.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 6 records for EC 4.2.1.59 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.2.1.59 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering | Mus musculus | 17 |
| Substrate recognition by the human fatty-acid synthase | Homo sapiens | 2 |
| Purification and characterizations of beta-Ketoacyl-[acyl-carrier-protein] reductase, beta-hydroxyacyl-[acyl-carrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from Spinacia… | Spinacia oleracea | 1 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| beta-hydroxyacyl-[acyl-carrier-protein] dehydrase | Spinacia oleracea | trans-2-dodecenoyl-[acyl-carrier protein] | — | 0.0031 | — | pH 7.8, 25 °C | PMID 6756317 | Open record: beta-hydroxyacyl-[acyl-carrier-protein] dehydrase, trans-2-dodecenoyl-[acyl-carrier protein] |
| fatty-acid synthase (HFAS) | Homo sapiens | crotonyl-CoA | 0.1 | 0.007 | 15 | pH 7, 25 °C | PMID 16215233 | Open record: fatty-acid synthase (HFAS), crotonyl-CoA |
| fatty-acid synthase (HFAS)variant K1699A | Homo sapiens | crotonyl-CoA | 0.4 | 0.04 | 10 | pH 7, 25 °C | PMID 16215233 | Open record: fatty-acid synthase (HFAS) variant K1699A, crotonyl-CoA |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acetoacetyl-CoA | 7.3 | 8.6 × 10⁻⁴ | 8.5 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acetoacetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acetyl-CoAacyl-CoA varied 0.1-100 μM; holo-ACP (60 μM) | 13.7 | 0.00163 | 8.4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acetyl-CoAholo-ACP (varied, extrapolated) | 99.2 | 0.012 | 8.3 × 10³ calc. | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acyl carrier protein (holo, murine FAS ACP domain) | — | 0.245 | — | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acyl carrier protein (holo, murine FAS ACP domain) | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | butyryl-CoA | 10.8 | 0.00164 | 6.6 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, butyryl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | crotonyl-CoA | 6 | 0.00136 | 4.4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, crotonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | hydroxybutyryl-CoA | 6.1 | 0.00172 | 3.6 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, hydroxybutyryl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | malonyl-CoAacyl-CoA varied 0.1-100 μM; holo-ACP (60 μM) | 15.6 | 0.00128 | 1.22 × 10⁴ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, malonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | malonyl-CoAholo-ACP (varied, extrapolated) | 119 | 0.0088 | 1.4 × 10⁴ calc. | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, malonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | methylbutyryl-CoA | 7.2 | 0.00206 | 3.5 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, methylbutyryl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | methylmalonyl-CoA | 4 | 6.2 × 10⁻⁴ | 6.5 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, methylmalonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | octanoyl-CoA | 4.1 | 7.3 × 10⁻⁴ | 5.6 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, octanoyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | palmitoyl-CoA | 2.5 | 0.0048 | 500 | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, palmitoyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | phenylacetyl-CoA | 6 | 9.6 × 10⁻⁴ | 6.2 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, phenylacetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | succinyl-CoA | 13.4 | 0.0021 | 6.4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, succinyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G/R606A | Mus musculus | acetyl-CoA | 13 | 0.003 | 4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G/R606A, acetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G/R606A | Mus musculus | malonyl-CoA | 5 | 0.018 | 300 | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G/R606A, malonyl-CoA |