Values CatLog read from this paper
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase
PMID 16279783doi:10.1021/jm050568oOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 20 records (30 values) from this paper: phenylethanolamine N-methyltransferase (hPNMT) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 10 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | 3-trifluoromethylphenylethanolamine | 0.0083 | 5.5 × 10⁻⁴ | 15 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT), 3-trifluoromethylphenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | anti-9-amino-6-(trifluoromethyl)benzonorbornene | 0.0062 | 0.0015 | 4.1 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT), anti-9-amino-6-(trifluoromethyl)benzonorbornene |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | phenylethanolamine | 0.0473 | 0.1 | 0.47 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT), phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | S-adenosyl-L-methioninephenylethanolamine | — | 0.0034 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT), S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | S-adenosyl-L-methionine3-trifluoromethylphenylethanolamine | — | 0.0012 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT), S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | S-adenosyl-L-methionineanti-9-amino-6-(trifluoromethyl)benzonorbornene | — | 0.002 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT), S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | 3-trifluoromethylphenylethanolamine | 0.001 | 0.055 | 0.018 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, 3-trifluoromethylphenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | anti-9-amino-6-(trifluoromethyl)benzonorbornene | 0.0043 | 0.025 | 0.17 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, anti-9-amino-6-(trifluoromethyl)benzonorbornene |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | phenylethanolamine | 0.0022 | 2.05 | 0.0011 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | S-adenosyl-L-methioninephenylethanolamine | — | 0.0083 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | S-adenosyl-L-methionine3-trifluoromethylphenylethanolamine | — | 0.0024 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | S-adenosyl-L-methionineanti-9-amino-6-(trifluoromethyl)benzonorbornene | — | 0.0051 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267N | Homo sapiens | phenylethanolamine | 0.0017 | 1.64 | 0.0010 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267N, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267N | Homo sapiens | S-adenosyl-L-methionine | — | 0.0071 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267N, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E219A | Homo sapiens | phenylethanolamine | 0.0218 | 0.58 | 0.038 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E219A, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E219A | Homo sapiens | S-adenosyl-L-methionine | — | 0.0071 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E219A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant K57A | Homo sapiens | phenylethanolamine | 0.0658 | 1.31 | 0.0503 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant K57A, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant K57A | Homo sapiens | S-adenosyl-L-methionine | — | 0.0117 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant K57A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant V53A | Homo sapiens | phenylethanolamine | 0.0567 | 1.63 | 0.0348 calc. | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant V53A, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant V53A | Homo sapiens | S-adenosyl-L-methionine | — | 0.0096 | — | pH 8, 30 °C | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant V53A, S-adenosyl-L-methionine |