EC 2.1.1.28: phenylethanolamine N-methyltransferase
TransferasesOpen in Browse
CatLog read 39 records for EC 2.1.1.28 from 3 papers, for 1 organism. Names in these papers: phenylethanolamine N-methyltransferase (hPNMT), phenylethanolamine N-methyltransferase.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 14 records for EC 2.1.1.28 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.1.1.28 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase | Homo sapiens | 20 |
| Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis | Homo sapiens | 15 |
| Kinetic and pH studies on human phenylethanolamine N-methyltransferase | Homo sapiens | 4 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| phenylethanolamine N-methyltransferase | Homo sapiens | (±) Octopamine | 0.0205 | 0.0055 | 3.7 | pH 8, 30 °C | PMID 24018397 | Open record: phenylethanolamine N-methyltransferase, (±) Octopamine |
| phenylethanolamine N-methyltransferase | Homo sapiens | 3-trifluoromethyl phenylethanolamine | 0.0083 | 5.4 × 10⁻⁴ | 15.5 | pH 8, 30 °C | PMID 24018397 | Open record: phenylethanolamine N-methyltransferase, 3-trifluoromethyl phenylethanolamine |
| phenylethanolamine N-methyltransferase | Homo sapiens | S-adenosyl-L-methioninecosubstrate (±) Octopamine | — | 0.0067 | — | pH 8, 30 °C | PMID 24018397 | Open record: phenylethanolamine N-methyltransferase, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase | Homo sapiens | S-adenosyl-L-methioninecosubstrate (±) 3-CF_3 PEA | — | 0.0012 | — | pH 8, 30 °C | PMID 24018397 | Open record: phenylethanolamine N-methyltransferase, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | (±)-p-octopamine | 0.02 | 0.0055 | 3.7 | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT), (±)-p-octopamine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | (±)-phenylethanolamineTable 1 | 0.043 | 0.099 | 0.43 | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT), (±)-phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | (±)-phenylethanolamineTable 5 | 0.047 | 0.099 | 0.47 calc. | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT), (±)-phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | 3-trifluoromethylphenylethanolamine | 0.0083 | 5.5 × 10⁻⁴ | 15 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT), 3-trifluoromethylphenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | anti-9-amino-6-(trifluoromethyl)benzonorbornene | 0.0062 | 0.0015 | 4.1 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT), anti-9-amino-6-(trifluoromethyl)benzonorbornene |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | cis-(1R,2S)-2-amino-1-tetralol | 0.0048 | 0.0053 | 0.92 | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT), cis-(1R,2S)-2-amino-1-tetralol |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | phenylethanolamine | 0.0473 | 0.1 | 0.47 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT), phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | S-adenosyl-L-methioninephenylethanolamine | — | 0.0034 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT), S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | S-adenosyl-L-methionine3-trifluoromethylphenylethanolamine | — | 0.0012 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT), S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | S-adenosyl-L-methionineanti-9-amino-6-(trifluoromethyl)benzonorbornene | — | 0.002 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT), S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT) | Homo sapiens | S-adenosyl-L-methionine | — | 0.0034 | — | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT), S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | 3-trifluoromethylphenylethanolamine | 0.001 | 0.055 | 0.018 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, 3-trifluoromethylphenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | anti-9-amino-6-(trifluoromethyl)benzonorbornene | 0.0043 | 0.025 | 0.17 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, anti-9-amino-6-(trifluoromethyl)benzonorbornene |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | phenylethanolamine | 0.0022 | 2.05 | 0.0011 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | S-adenosyl-L-methioninephenylethanolamine | — | 0.0083 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | S-adenosyl-L-methionine3-trifluoromethylphenylethanolamine | — | 0.0024 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267A | Homo sapiens | S-adenosyl-L-methionineanti-9-amino-6-(trifluoromethyl)benzonorbornene | — | 0.0051 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267N | Homo sapiens | phenylethanolamine | 0.0017 | 1.64 | 0.0010 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267N, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant D267N | Homo sapiens | S-adenosyl-L-methionine | — | 0.0071 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant D267N, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E185A | Homo sapiens | (±)-phenylethanolamine | 0.0028 | 0.102 | 0.028 calc. | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E185A, (±)-phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E185A | Homo sapiens | S-adenosyl-L-methionine | — | 0.0017 | — | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E185A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E185D | Homo sapiens | (±)-phenylethanolamine | 0.0142 | 0.32 | 0.044 calc. | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E185D, (±)-phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E185D | Homo sapiens | S-adenosyl-L-methionine | — | 0.014 | — | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E185D, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E185Q | Homo sapiens | (±)-phenylethanolamine | 1.7 × 10⁻⁴ | 0.101 | 0.0017 calc. | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E185Q, (±)-phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E185Q | Homo sapiens | S-adenosyl-L-methionine | — | 0.0013 | — | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E185Q, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E219A | Homo sapiens | phenylethanolamine | 0.0218 | 0.58 | 0.038 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E219A, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E219A | Homo sapiens | S-adenosyl-L-methionine | — | 0.0071 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E219A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E219Q | Homo sapiens | (±)-phenylethanolamine | 0.048 | 0.179 | 0.27 calc. | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E219Q, (±)-phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant E219Q | Homo sapiens | S-adenosyl-L-methionine | — | 0.0067 | — | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant E219Q, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant K57A | Homo sapiens | phenylethanolamine | 0.0658 | 1.31 | 0.0503 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant K57A, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant K57A | Homo sapiens | S-adenosyl-L-methionine | — | 0.0117 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant K57A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant V53A | Homo sapiens | phenylethanolamine | 0.0567 | 1.63 | 0.0348 calc. | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant V53A, phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant V53A | Homo sapiens | S-adenosyl-L-methionine | — | 0.0096 | — | pH 8, 30 °C | PMID 16279783 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant V53A, S-adenosyl-L-methionine |
| phenylethanolamine N-methyltransferase (hPNMT)variant Y35F | Homo sapiens | (±)-phenylethanolamine | 0.0175 | 1.73 | 0.0101 calc. | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant Y35F, (±)-phenylethanolamine |
| phenylethanolamine N-methyltransferase (hPNMT)variant Y35F | Homo sapiens | S-adenosyl-L-methionine | — | 0.045 | — | pH 8, 30 °C | PMID 16363801 | Open record: phenylethanolamine N-methyltransferase (hPNMT) variant Y35F, S-adenosyl-L-methionine |