Values CatLog read from this paper
The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases
PMID 16407305doi:10.1074/jbc.m512594200Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 23 records (66 values) from this paper: serum paraoxonase 1 (PON1) from Oryctolagus cuniculus.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
EC 3.1.1.2, EC 3.1.1.81, EC 3.1.8.1
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| serum paraoxonase 1 (PON1) | Oryctolagus cuniculus | 5-(thiobutyl)butyrolactone | 116 | 0.27 | 440 | pH 8 | Open record: serum paraoxonase 1 (PON1), 5-(thiobutyl)butyrolactone |
| serum paraoxonase 1 (PON1) | Oryctolagus cuniculus | 5-(thiobutyl)butyrolactone | 104 | — | 750 | Open record: serum paraoxonase 1 (PON1), 5-(thiobutyl)butyrolactone | |
| serum paraoxonase 1 (PON1) | Oryctolagus cuniculus | paraoxon | 4.2 | 0.86 | 4.89 | pH 8 | Open record: serum paraoxonase 1 (PON1), paraoxon |
| serum paraoxonase 1 (PON1) | Oryctolagus cuniculus | phenyl acetate | 854 | 1.3 | 668 | pH 8 | Open record: serum paraoxonase 1 (PON1), phenyl acetate |
| serum paraoxonase 1 (PON1) | Oryctolagus cuniculus | γ-caprolactone | 44 | 1 | 43 | pH 8 | Open record: serum paraoxonase 1 (PON1), γ-caprolactone |
| serum paraoxonase 1 (PON1) | Oryctolagus cuniculus | γ-nonalactone | 31 | 0.39 | 78 | pH 8 | Open record: serum paraoxonase 1 (PON1), γ-nonalactone |
| serum paraoxonase 1 (PON1) | Oryctolagus cuniculus | δ-valerolactone | 210 | 0.57 | 370 | pH 8 | Open record: serum paraoxonase 1 (PON1), δ-valerolactone |
| serum paraoxonase 1 (PON1)variant H115Q | Oryctolagus cuniculus | 5-(thiobutyl)butyrolactone | 7.6 | 1.6 | 4.72 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q, 5-(thiobutyl)butyrolactone |
| serum paraoxonase 1 (PON1)variant H115Q | Oryctolagus cuniculus | paraoxon | 1 | 1.35 | 0.738 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q, paraoxon |
| serum paraoxonase 1 (PON1)variant H115Q | Oryctolagus cuniculus | phenyl acetate | 10.5 | 8.1 | 1.31 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q, phenyl acetate |
| serum paraoxonase 1 (PON1)variant H115Q | Oryctolagus cuniculus | γ-caprolactone | 2.27 | 3.8 | 0.6 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q, γ-caprolactone |
| serum paraoxonase 1 (PON1)variant H115Q | Oryctolagus cuniculus | γ-nonalactone | 0.38 | 1.54 | 0.25 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q, γ-nonalactone |
| serum paraoxonase 1 (PON1)variant H115Q | Oryctolagus cuniculus | δ-valerolactone | 69.4 | 8.5 | 8.2 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q, δ-valerolactone |
| serum paraoxonase 1 (PON1)variant H115Q/H134Q | Oryctolagus cuniculus | 5-(thiobutyl)butyrolactone | 1.74 | 1.83 | 0.965 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q/H134Q, 5-(thiobutyl)butyrolactone |
| serum paraoxonase 1 (PON1)variant H115Q/H134Q | Oryctolagus cuniculus | paraoxon | 4.7 | 1.18 | 3.98 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q/H134Q, paraoxon |
| serum paraoxonase 1 (PON1)variant H115Q/H134Q | Oryctolagus cuniculus | phenyl acetate | 7.4 | 9.7 | 0.773 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q/H134Q, phenyl acetate |
| serum paraoxonase 1 (PON1)variant H115Q/H134Q | Oryctolagus cuniculus | δ-valerolactone | — | — | 2.97 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H115Q/H134Q, δ-valerolactone |
| serum paraoxonase 1 (PON1)variant H134Q | Oryctolagus cuniculus | 5-(thiobutyl)butyrolactone | 19.4 | 0.68 | 28.6 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H134Q, 5-(thiobutyl)butyrolactone |
| serum paraoxonase 1 (PON1)variant H134Q | Oryctolagus cuniculus | paraoxon | 12.7 | 0.75 | 17 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H134Q, paraoxon |
| serum paraoxonase 1 (PON1)variant H134Q | Oryctolagus cuniculus | phenyl acetate | 185 | 3.6 | 50.9 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H134Q, phenyl acetate |
| serum paraoxonase 1 (PON1)variant H134Q | Oryctolagus cuniculus | γ-caprolactone | 25 | 2.97 | 8.4 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H134Q, γ-caprolactone |
| serum paraoxonase 1 (PON1)variant H134Q | Oryctolagus cuniculus | γ-nonalactone | 5.57 | 0.89 | 6.24 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H134Q, γ-nonalactone |
| serum paraoxonase 1 (PON1)variant H134Q | Oryctolagus cuniculus | δ-valerolactone | 40 | 0.95 | 42.2 | pH 8 | Open record: serum paraoxonase 1 (PON1) variant H134Q, δ-valerolactone |