CatLogenzyme kinetics catalog

Values CatLog read from this paper

Impact of naturally occurring variants of HCV protease on the binding of different classes of protease inhibitors

PMID 16445277doi:10.1021/bi051565gOpen in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 16 records (32 values) from this paper: NS3/NS4A serine protease (single-chain NS3 protease domain) from Hepatitis C virus.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 16 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.

EC 3.4.21.98

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
NS3/NS4A serine protease (single-chain NS3 protease domain)Hepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.40.0039100 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)Hepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.430.0026170 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)Hepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.570.007279 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant D168QHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.330.004279 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant D79EHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.220.005837 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant Q80GHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.220.005539 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant R123THepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.130.01211 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant R123T/D168QHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.250.005149 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant R123T/D168Q/V132LHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.30.00560 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant S122KHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.580.0048120 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant S122K/V132LHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.250.004457 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant T160AHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.20.00540 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant V132LHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.0950.003428 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant V78AHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.30.005951 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant V78A/D79E/Q80GHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.170.007323 calc.pH 6.5, 30 °COpen
NS3/NS4A serine protease (single-chain NS3 protease domain)variant V78A/D79E/Q80G/S122K/V132LHepatitis C virusAc-DTEDVVP(Nva)-O-4-phenylazophenyl ester0.130.004728 calc.pH 6.5, 30 °COpen