CatLogenzyme kinetics catalog

Values CatLog read from this paper

Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol

PMID 17029589doi:10.1042/bj20060632Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 52 records (52 values) from this paper: MDR1/P-glycoprotein (ABCB1) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 7.6.2.1, EC 7.6.2.2

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
MDR1/P-glycoprotein (ABCB1)Homo sapienscorticosterone0% (w/w) cholesterol—0.485—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienscorticosterone20% (w/w) cholesterol—0.21—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensdexamethasone0% (w/w) cholesterol—0.826—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensdexamethasone5% (w/w) cholesterol—0.527—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensdexamethasone10% (w/w) cholesterol—0.423—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensdexamethasone20% (w/w) cholesterol—0.394—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensdigoxin0% (w/w) cholesterol—0.181—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensdigoxin5% (w/w) cholesterol—0.12—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensdigoxin10% (w/w) cholesterol—0.111—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensdigoxin20% (w/w) cholesterol—0.076—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienshydrocortisone0% (w/w) cholesterol—1.498—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienshydrocortisone20% (w/w) cholesterol—0.475—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensnicardipine0% (w/w) cholesterol—0.0026—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensnicardipine5% (w/w) cholesterol—0.0015—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensnicardipine10% (w/w) cholesterol—0.0016—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensnicardipine20% (w/w) cholesterol—0.001—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelPC/PE/PS (4:4:2) liposomes containing 0% (w/w) cholesterol—0.0014—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelPC/PE/PS (4:4:2) liposomes containing 5% (w/w) cholesterol—0.0013—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelPC/PE/PS (4:4:2) liposomes containing 10% (w/w) cholesterol—0.0014—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelPC/PE/PS (4:4:2) liposomes containing 20% (w/w) cholesterol—0.0016—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelliposomes containing 20% (w/w) stigmasterol—0.0014—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelliposomes containing 20% (w/w) sitosterol—0.0011—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelliposomes containing 20% (w/w) campesterol—0.001—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelliposomes containing 20% (w/w) ergosterol—9 × 10⁻⁴—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine 1230% (w/w) cholesterol—0.021—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine 1235% (w/w) cholesterol—0.016—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine 12310% (w/w) cholesterol—0.013—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine 12320% (w/w) cholesterol—0.01—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine B0% (w/w) cholesterol—0.014—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine B5% (w/w) cholesterol—0.009—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine B10% (w/w) cholesterol—0.011—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine B20% (w/w) cholesterol—0.007—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvalinomycin0% (w/w) cholesterol—0.0025—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvalinomycin5% (w/w) cholesterol—0.0022—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvalinomycin10% (w/w) cholesterol—0.0026—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvalinomycin20% (w/w) cholesterol—0.0035—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; Table 1—0.0041—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; Table 1—0.0038—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; Table 1—0.0027—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; Table 1—0.0022—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; in the text—0.0047—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; in the text—0.0019—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamilcontrol membranes (no MβCD treatment); 2 mM NaATP; 2 mM DTT—0.0032—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamilcholesterol depleted with 10 mM MβCD (90 min, 25 °C)—0.0044—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvinblastine0% (w/w) cholesterol—0.0017—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvinblastine5% (w/w) cholesterol—0.0013—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvinblastine10% (w/w) cholesterol—0.0012—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvinblastine20% (w/w) cholesterol—0.0016—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvincristine0% (w/w) cholesterol—0.0037—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvincristine5% (w/w) cholesterol—0.0027—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvincristine10% (w/w) cholesterol—0.0028—pH 7.5, 37 °COpen
MDR1/P-glycoprotein (ABCB1)Homo sapiensvincristine20% (w/w) cholesterol—0.0039—pH 7.5, 37 °COpen