CatLogenzyme kinetics catalog

EC 7.6.2.2: ABC-type xenobiotic transporter

TranslocasesOpen in Browse

CatLog read 117 records for EC 7.6.2.2 from 5 papers, for 2 organisms. Names in these papers: MDR1/P-glycoprotein (ABCB1), P-glycoprotein (P-gp, ABCB1/MDR1), P-glycoprotein (P-gp, MDR1), multidrug resistance-associated protein 3 (Mrp3) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 143 records for EC 7.6.2.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 7.6.2.2 in Browse.

Papers

PaperOrganismsRecords
Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterolHomo sapiens52
Functional role of the linker region in purified human P-glycoproteinHomo sapiens35
In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous systemHomo sapiens24
ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicus4
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugsHomo sapiens2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
MDR1/P-glycoprotein (ABCB1)Homo sapienscorticosterone0% (w/w) cholesterol—0.485—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienscorticosterone20% (w/w) cholesterol—0.21—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensdexamethasone0% (w/w) cholesterol—0.826—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensdexamethasone5% (w/w) cholesterol—0.527—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensdexamethasone10% (w/w) cholesterol—0.423—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensdexamethasone20% (w/w) cholesterol—0.394—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensdigoxin0% (w/w) cholesterol—0.181—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensdigoxin5% (w/w) cholesterol—0.12—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensdigoxin10% (w/w) cholesterol—0.111—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensdigoxin20% (w/w) cholesterol—0.076—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienshydrocortisone0% (w/w) cholesterol—1.498—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienshydrocortisone20% (w/w) cholesterol—0.475—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensnicardipine0% (w/w) cholesterol—0.0026—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensnicardipine5% (w/w) cholesterol—0.0015—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensnicardipine10% (w/w) cholesterol—0.0016—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensnicardipine20% (w/w) cholesterol—0.001—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelPC/PE/PS (4:4:2) liposomes containing 0% (w/w) cholesterol—0.0014—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelPC/PE/PS (4:4:2) liposomes containing 5% (w/w) cholesterol—0.0013—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelPC/PE/PS (4:4:2) liposomes containing 10% (w/w) cholesterol—0.0014—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelPC/PE/PS (4:4:2) liposomes containing 20% (w/w) cholesterol—0.0016—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelliposomes containing 20% (w/w) stigmasterol—0.0014—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelliposomes containing 20% (w/w) sitosterol—0.0011—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelliposomes containing 20% (w/w) campesterol—0.001—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapienspaclitaxelliposomes containing 20% (w/w) ergosterol—9 × 10⁻⁴—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine 1230% (w/w) cholesterol—0.021—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine 1235% (w/w) cholesterol—0.016—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine 12310% (w/w) cholesterol—0.013—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine 12320% (w/w) cholesterol—0.01—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine B0% (w/w) cholesterol—0.014—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine B5% (w/w) cholesterol—0.009—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine B10% (w/w) cholesterol—0.011—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensrhodamine B20% (w/w) cholesterol—0.007—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvalinomycin0% (w/w) cholesterol—0.0025—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvalinomycin5% (w/w) cholesterol—0.0022—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvalinomycin10% (w/w) cholesterol—0.0026—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvalinomycin20% (w/w) cholesterol—0.0035—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; Table 1—0.0041—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; Table 1—0.0038—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; Table 1—0.0027—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; Table 1—0.0022—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; in the text—0.0047—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamil1 mM NaATP; 1 mM MgCl2; ADP measured by HPLC; in the text—0.0019—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamilcontrol membranes (no MβCD treatment); 2 mM NaATP; 2 mM DTT—0.0032—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensverapamilcholesterol depleted with 10 mM MβCD (90 min, 25 °C)—0.0044—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvinblastine0% (w/w) cholesterol—0.0017—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvinblastine5% (w/w) cholesterol—0.0013—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvinblastine10% (w/w) cholesterol—0.0012—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvinblastine20% (w/w) cholesterol—0.0016—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvincristine0% (w/w) cholesterol—0.0037—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvincristine5% (w/w) cholesterol—0.0027—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvincristine10% (w/w) cholesterol—0.0028—pH 7.5, 37 °CPMID 17029589Open
MDR1/P-glycoprotein (ABCB1)Homo sapiensvincristine20% (w/w) cholesterol—0.0039—pH 7.5, 37 °CPMID 17029589Open
MRP4 (ABCC4), multidrug resistance protein 4Homo sapiensprostaglandin E1—0.0021—37 °CPMID 12835412Open
MRP4 (ABCC4), multidrug resistance protein 4Homo sapiensprostaglandin E2—0.0034—37 °CPMID 12835412Open
multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicusadenosine 5'-triphosphateuptake of 55 nM [3H]E217βG—1.36—pH 7.4, 37 °CPMID 10644759Open
multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicusadenosine 5'-triphosphateuptake of 1.2 µM [3H]TC—0.66—pH 7.4, 37 °CPMID 10644759Open
multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicustaurocholate—0.0159—pH 7.4, 37 °CPMID 10644759Open
multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicustaurolithocholate-3-sulfate—0.00306—pH 7.4, 37 °CPMID 10644759Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiens3',6'-di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein tetraacetoxymethyl ester3.190.002031.57 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensadenosine 5'-triphosphate5 mM MgATP; basal ATPase; no transport substrate0.189——pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensadenosine 5'-triphosphateMgATP varied; in the presence of 50 µM verapamil—0.59—pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensColchicine1.250.721.66pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensDigoxin0.7910.1874.23pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensNicardipine3.480.001911.82 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensPaclitaxel0.418.74 × 10⁻⁴469pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensRhodamine 1231.840.035452pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensRhodamine B2.230.029874.9pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensValinomycin2.953.95 × 10⁻⁴7.46 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensVerapamil3.280.00423775pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)Homo sapiensVinblastine1.90.001211.56 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiens3',6'-di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein tetraacetoxymethyl ester11.20.003353.36 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensadenosine 5'-triphosphate2.95——pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensColchicine6.40.2822.9pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensDigoxin5.990.10159.2pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensNicardipine7.83.83 × 10⁻⁴2.04 × 10⁴pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensPaclitaxel3.696.65 × 10⁻⁴5.63 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensRhodamine 1238.560.0175489pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensRhodamine B7.220.0142509pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensValinomycin11.70.001517.77 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensVerapamil7.716.37 × 10⁻⁴1.21 × 10⁴pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant chymotrypsin-cleavedHomo sapiensVinblastine6.540.002362.77 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiens3',6'-di(O-acetyl)-4',5'-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein tetraacetoxymethyl ester11.20.002434.59 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensadenosine 5'-triphosphate5 mM MgATP; basal ATPase; no transport substrate2.38——pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensadenosine 5'-triphosphateMgATP varied; in the presence of 50 µM verapamil—0.89—pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensColchicine7.810.27828.2pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensDigoxin5.650.11947.3pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensNicardipine8.446.52 × 10⁻⁴1.29 × 10⁴pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensPaclitaxel3.447.75 × 10⁻⁴4.44 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensRhodamine 1238.190.0118692pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensRhodamine B6.990.0109641pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensValinomycin11.10.001111 × 10⁴pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensVerapamil8.276.14 × 10⁻⁴1.35 × 10⁴pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, ABCB1/MDR1)variant trypsin-cleavedHomo sapiensVinblastine6.390.002013.17 × 10³pH 7.4, 37 °CPMID 19490125Open
P-glycoprotein (P-gp, MDR1)Homo sapiens9-Hydroxyrisperidone—0.177—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensBuspirone—0.118—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensChlorpromazine—0.041—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensCitalopram—0.441—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensCyclobenzaprine—0.0774—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensDiazepam—0.141—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensFluoxetine—0.0516—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensFluvoxamine—0.18—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensHydroxyzine—0.1—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensLoperamide—0.0114—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensLoratadine—0.0014—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensMidazolam—0.0444—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensNortriptyline—0.056—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensParoxetine—0.0262—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensPrazosin—0.0546—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensPrednisone—0.291—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensPropoxyphene—0.18—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensQuinidine—0.0137—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensRisperidone—0.0361—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensRitonavir—0.0113—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensSertraline—0.0094—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensTrazodone—0.172—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensVerapamil—0.009—pH 6.8, 37 °CPMID 17962372Open
P-glycoprotein (P-gp, MDR1)Homo sapiensZolpidem—0.198—pH 6.8, 37 °CPMID 17962372Open