CatLogenzyme kinetics catalog

Values CatLog read from this paper

In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system

PMID 17962372doi:10.1124/dmd.107.017434Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 24 records (24 values) from this paper: P-glycoprotein (P-gp, MDR1) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 7.6.2.1, EC 7.6.2.2

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
P-glycoprotein (P-gp, MDR1)Homo sapiens9-Hydroxyrisperidone—0.177—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensBuspirone—0.118—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensChlorpromazine—0.041—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensCitalopram—0.441—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensCyclobenzaprine—0.0774—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensDiazepam—0.141—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensFluoxetine—0.0516—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensFluvoxamine—0.18—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensHydroxyzine—0.1—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensLoperamide—0.0114—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensLoratadine—0.0014—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensMidazolam—0.0444—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensNortriptyline—0.056—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensParoxetine—0.0262—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensPrazosin—0.0546—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensPrednisone—0.291—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensPropoxyphene—0.18—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensQuinidine—0.0137—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensRisperidone—0.0361—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensRitonavir—0.0113—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensSertraline—0.0094—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensTrazodone—0.172—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensVerapamil—0.009—pH 6.8, 37 °COpen
P-glycoprotein (P-gp, MDR1)Homo sapiensZolpidem—0.198—pH 6.8, 37 °COpen